19788-37-5

Basic information

• Product Name: 4-(CHLOROMETHYL)-3,5-DIMETHYLISOXAZOLE
• Synonyms: 4-(CHLOROMETHYL)-3,5-DIMETHYLISOXAZOLE;AKOS BC-3064;TIMTEC-BB SBB004107;4-(chloromethyl)-3,5-dimethyl-isoxazol;3,5-Dimethyl-4-chloromethyl isoxazole;4-(Chloromethyl)-3,5-dimethylisoxazole,98%;4-(Chloromethyl)-3,5-dimethylisoxazole,96%;4-(chloromethyl)-3,5-dimethylisoxazole(SALTDATA: FREE)
• CAS NO: 19788-37-5
• Molecular Formula: C₆H₈ClNO
• Molecular Weight: 145.59
• EINECS: 243-312-4
• Product Categories: Oxazole&Isoxazole;Halogenated Heterocycles;Heterocyclic Building Blocks;Isoxazoles;IsoxazolesBuilding Blocks
• Mol File: 19788-37-5.mol

Chemical Properties

• Melting Point: 88-90°C
• Boiling Point: 87-88 °C8 mm Hg(lit.)
• Flash Point: 204 °F
• Appearance: Colorless to yellow liquid
• Density: 1.173 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.167mmHg at 25°C
• Refractive Index: n20/D 1.486(lit.)
• Storage Temp.: 0-6°C
• PKA: -1.73±0.28(Predicted)
• BRN: 110780
• CAS DataBase Reference: 4-(CHLOROMETHYL)-3,5-DIMETHYLISOXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(CHLOROMETHYL)-3,5-DIMETHYLISOXAZOLE(19788-37-5)
• EPA Substance Registry System: 4-(CHLOROMETHYL)-3,5-DIMETHYLISOXAZOLE(19788-37-5)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38-37/38-36
• Safety Statements: 26-36
• RIDADR: UN 3334
• WGK Germany: 3
• TSCA: Yes
• HazardClass: IRRITANT
• Hazardous Substances Data: 19788-37-5(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
4-(Chloromethyl)-3,5-dimethylisoxazole is used as a key intermediate in the synthesis of complex organic molecules, particularly in the preparation of:
4(3-oxoalkyl)isoxazole: 4-(CHLOROMETHYL)-3,5-DIMETHYLISOXAZOLE is synthesized using 4-(Chloromethyl)-3,5-dimethylisoxazole as a starting material, which can be further utilized in various chemical applications.
(E)-3,5-dimethyl-4-(2-(thiophene-3-yl)vinyl)isoxazole: 4-(CHLOROMETHYL)-3,5-DIMETHYLISOXAZOLE is another product derived from 4-(Chloromethyl)-3,5-dimethylisoxazole, which can be used in the development of pharmaceuticals, agrochemicals, or other specialty chemicals.
The specific application reasons for these synthesized compounds may vary depending on their properties and the requirements of the industries they are used in.

InChI:InChI=1/C6H8ClNO/c1-4-6(3-7)5(2)9-8-4/h3H2,1-2H3

Upstream product

• 300-87-8 3,5-dimethyl-1,2-oxazole 
• 50-00-0 formaldehyd 
• 19788-36-4 4-hydroxymethyl-3,5-dimethylisoxazole 

Downstream Products

• 103041-81-2 N-(3,5-dimethyl-isoxazol-4-ylmethyl)-N',N'-dimethyl-N-phenyl-ethylenediamine 
• 19788-36-4 4-hydroxymethyl-3,5-dimethylisoxazole 
• 2510-36-3 3,5-dimethyl-4-isoxazolecarboxylic acid 
• 93548-18-6 ((3,5-dimethylisoxazole-4-yl)methoxy)ethane 
• 119750-79-7 (R)-3-(3,5-Dimethyl-isoxazol-4-yl)-2-methyl-2-phenyl-propionaldehyde 
• 119750-79-7 (S)-3-(3,5-Dimethyl-isoxazol-4-yl)-2-methyl-2-phenyl-propionaldehyde 
• 85679-14-7 1-(3,5-Dimethyl-isoxazol-4-ylmethyl)-cyclohex-3-enecarbaldehyde 
• 10557-82-1 3,4,5-trimethylisoxazole 
• 85679-16-9 (Z)-4-Amino-3-hydroxymethyl-pent-3-en-2-one 
• 75632-85-8 1,2-bis(3,5-dimethylisoxazol-4-yl)ethane 
• 146796-45-4 (3,5-dimethylisoxazol-4-yl)methanethiol 
• 215299-08-4 5-(2-ethoxyphenyl)-3-methyl-1-(3,5-dimethylisoxazol-4-yl)methyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 
• 582303-17-1 C₂₅H₄₂NO₆PSi 
• 1025771-57-6 (R)-N-(4-chloro-3-((3,5-dimethylisoxazol-4-yl)methoxy)benzyl)-1-(3-chlorophenyl)ethanamine 

Relevant articles and documents

NOVEL PYRIMIDINE DERIVATIVES AND THEIR USE AS PPAR-ALPHA MODULATORS

The invention relates to novel pyrimidine derivatives of general formula (I), methods for the production thereof, their use for treating and/or preventing diseases, and to their use for producing medicaments for treating and/or preventing diseases, preferably for treating and/or preventing cardiovascular diseases, particularly dyslipidemia, arteriosclerosis, insufficiency of the heart, thrombosis and metabolic syndrome.

Synthesis of (isoxazol-4-ylmethyl)triphenylphosphonium salts derived from 5-alkyiand 5-aryl-3-methylisoxazoles

The synthesis of (isoxazol-4-ylmethyl)triphenylphosphonium salts derived from 5-alkyl- and 5-aryl-3-methylisoxazoles has been carried out. This method involves the preparation of several 4-(chloromethyl)isoxazoles which are suitable precusors for these phosphonium salts. The phosphonium salts were completely characterized by spectroscopic methods and were obtained in very good to quantitative yields.

PHARMACOLOGICALLY ACTIVE GUANIDINE COMPOUNDS

The compounds are substituted thioalkyl-, aminoalkyl-and oxyalkyl-guanidines which are inhibitors of histamine activity.

PHARMACOLOGICALLY ACTIVE THIOUREA AND UREA COMPOUNDS

The compounds are substituted thioalkyl-, aminoalkyl-and oxyalkyl-thioureas and ureas which are inhibitors of histamine activity.