10557-82-1Relevant articles and documents
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Lockhart et al.
, p. 3107,3110 (1969)
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Palladium-Catalyzed Methylation of Aryl, Heteroaryl, and Vinyl Boronate Esters
Haydl, Alexander M.,Hartwig, John F.
supporting information, p. 1337 - 1341 (2019/02/26)
A method for the direct methylation of aryl, heteroaryl, and vinyl boronate esters is reported, involving the reaction of iodomethane with aryl-, heteroaryl-, and vinylboronate esters catalyzed by palladium and PtBu2Me. This transformation occurs with a remarkably broad scope and is suitable for late-stage derivatization of biologically active compounds via the boronate esters. The unique capabilities of this method are demonstrated by combining carbon-boron bond-forming reactions with palladium-catalyzed methylation in a tandem transformation.
Continuous-flow microliter microwave irradiation in the synthesis of isoxazole derivatives: An optimization procedure
Rodriguez, Antoniom.,Juan, Alberto,Gomez, M.Victoria,Moreno, Andres,De La Hoz, Antonio
experimental part, p. 2527 - 2530 (2012/08/29)
An efficient method was developed for the synthesis of 3,4,5-trisubstituted and 3,5-disubstituted isoxazoles by using continuous-flow microwave-heated microreactors. A study on the separate effects of the temperature, continuous-flow regime, and microwave irradiation showed that the continuous-flow regime had important effects for less reactive diketones, where microwave heating enhanced the reaction, permitting the formation of 5-methyl-3-phenylisoxazole, which was not formed in the absence of microwaves. Georg Thieme Verlag Stuttgart · New York.
Oxidative nitration of mononitroalkanes in a system sodium nitrite-polyhaloalkane
Petrova,Shcherbinin,Bazanov,Tselinskii
, p. 646 - 651 (2008/02/08)
In reaction of nitroethane lithium salt with sodium nitrite in DMSO, DMF or HMPA involving polyhaloalkanes 1,1-dinitroethane formed in a high yield. The highest yield was obtained with bromo-and iododerivatives. The reaction fits to a kinetic equation of over all second order: the first with respect to the nitroethane anion, and the first in polyhaloalkane. The rate constants of the process are linearly dependent on the electron affinities of the perhaloalkanes molecules. Nauka/Interperiodica 2007.