19794-10-6

Basic information

• Product Name: BOC-ALA-ALA-OME
• Synonyms: BOC-L-ALANYL-L-ALANINE METHYL ESTER;BOC-ALA-ALA-OME;(S)-methyl 2-((S)-2-(tert-butoxycarbonylamino)propanamido)propanoate;REF DUPL: Boc-Ala-Ala-OMe;N-[(tert-Butoxy)carbonyl]-L-alanyl-L-alanine methyl ester;N-[N-[(tert-Butoxy)carbonyl]-L-alanyl]-L-alanine methyl ester;N-Boc-L-alanyl-L-alanine Methyl ester, 97%;Boc-L-Ala-L-Ala-OMe
• CAS NO: 19794-10-6
• Molecular Formula: C₁₂H₂₂N₂O₅
• Molecular Weight: 274.31
• Mol File: 19794-10-6.mol

Chemical Properties

• Melting Point: 110-111℃
• Appearance: /
• Density: 1.101
• CAS DataBase Reference: BOC-ALA-ALA-OME(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-ALA-ALA-OME(19794-10-6)
• EPA Substance Registry System: BOC-ALA-ALA-OME(19794-10-6)

Safety Data

• Hazardous Substances Data: 19794-10-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
BOC-ALA-ALA-OME is used as a building block for the synthesis of peptide and protein-based drugs, contributing to the development of novel pharmaceuticals with potential therapeutic applications.
Used in Research and Development:
In the pharmaceutical industry, BOC-ALA-ALA-OME is utilized in research and development to explore its potential in creating new drugs and understanding its chemical properties and interactions.
Used in Chemical Reactions:
The BOC protecting group in BOC-ALA-ALA-OME allows for specific reactions to occur at the amino acid group, which is crucial for the synthesis of complex molecules and the development of advanced drug candidates.
Used in Property Manipulation:
The omega-methyl ester group in BOC-ALA-ALA-OME can be selectively removed or manipulated, enabling the alteration of the compound's properties to suit specific pharmaceutical applications or to enhance its effectiveness in drug delivery systems.

Upstream product

• 50903-48-5 N-tert.butyloxycarbonyl-alanine pentafluorophenyl ester 
• 128369-70-0 (S)-methyl 2-(((allyloxy)carbonyl)amino)propanoate 
• 527-69-5 2-furancarbonyl chloride 
• 170454-73-6 (S)-2-((R)-2-tert-Butoxycarbonylamino-3-iodo-propionylamino)-propionic acid methyl ester 
• 10065-72-2 L-Alanine methyl ester 
• 133039-96-0 (S)-(1-fluoro-1-oxoprop-2-yl)carbamic acid tert-butyl ester 
• 67-56-1 methanol 
• 27317-69-7 N-tert-butoxycarbonyl-L-alanyl-L-alanine 
• 15761-38-3 L-N-Boc-Ala 
• 1280225-71-9 C₁₈H₂₈N₂O₆ 
• 2491-20-5 L-alanine methyl ester hydrochloride 
• 13515-97-4 methyl 2-aminopropanoate monohydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1948-31-8 di-L-alanine 

Downstream Products

• 1429338-47-5 Boc-Tyr-Ala-Ala-OMe 
• 160480-13-7 Boc-Tyr-Ala-Ala-OH 
• 1422736-96-6 Bz-VGAψ[CSe-NH]AA-NH2 
• 1278592-44-1 Nα-(4-nitrobenzoyl)-Nε-thioacetyllysylalanylalanine methyl ester 
• 1278592-50-9 Nα-(4-nitrobenzoyl)-Nε-Boc-lysylalanylalanine methyl ester 
• 73974-13-7 7-<<1-(Biphenyl-4-yl)-1-methylethoxycarbonyl>-alanyl-alanyl-alanylamino>cephalosporansaeure 
• 73974-11-5 6-<<1-(Biphenyl-4-yl)-1-methylethoxycarbonyl>alanyl-alanyl-alanylamino>penicillansaeure 
• 73974-15-9 6-(Benzyloxycarbonyl-alanyl-alanyl-alanylamino)penicillansaeure 
• 3057-69-0 N-[(benzyloxy)carbonyl]-L-alanyl-L-alanyl-L-alanine methyl ester 
• 13585-98-3 N^α-benzyloxycarbobyl-L-alanyl-L-alanyl-L-alanine 

Relevant articles and documents

Bicomponent β-sheet assembly of dipeptide fluorophores of opposite polarity and sensitive detection of nitro-explosives

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Backbone thioamide directed macrocyclisation: Lactam stapling of peptides

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Discovery of a novel inhibitor of nitric oxide production with potential therapeutic effect on acute inflammation

Inflammation as a host's excessive immune response to stimulation, is involved in the development of numerous diseases. To discover novel anti-inflammatory agents and based on our previous synthetic work on marine natural product Chrysamide B, it and a series of derivatives were synthesized and evaluated for their anti-inflammatory activity on inhibition of LPS-induced NO production. Then the preliminary structure–activity relationships were conducted. Among them, Chrysamide B is the most potent anti-inflammatory agent with low cytotoxicity and strong inhibition on the production of NO (IC50 = 0.010 μM) and the activity of iNOS (IC50 = 0.082 μM) in LPS-stimulated RAW 264.7 cells. Primary studies suggested that the mechanism of action may be that it interfered the formation of active dimeric iNOS but not affected transcription and translation. Furthermore, its good performance of anti-inflammatory effect on LPS-induced multiple inflammatory cytokines production, carrageenan-induced paw edema, and endotoxin-induced septic mice, was observed. We believe that these findings would provide an idea for the further modification and research of these analogs in the future.

Design, synthesis and antitumor activity evaluation of Chrysamide B derivatives

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ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF

The invention provides anti-VISTA antibody drug conjugates which may be used for targeted delivery of anti-inflammatory agents such as steroids to immune cells, e.g., myeloid cells. The invention also provides methods of using anti-VISTA antibody drug conjugates in the treatment of inflammatory and/or autoimmune conditions and/or for alleviating the toxicity of anti-inflammatory agents such as steroids.

Effect of Stereochemistry on Chirality and Gelation Properties of Supramolecular Self-Assemblies

Although chiral nanostructures have been fabricated at various structural levels, the transfer and amplification of chirality from molecules to supramolecular self-assemblies are still puzzling, especially for heterochiral molecules. Herein, four series o

Chiral Overpass Induction in Dynamic Helical Polymers Bearing Pendant Groups with Two Chiral Centers

The dynamic behavior of helical polymers bearing pendant groups with two chiral centers was studied. Controlled conformational changes at the chiral units placed either closer to or further away from the main chain promote different helical structures. Al

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