198021-38-4Relevant articles and documents
A practical synthesis of enantiopure 4,4,4-trifluoro-allo-threonine from an easily available fluorinated building block
Cho, Joonil,Irie, Siho,Iwahashi, Nobutaka,Itoh, Yoshimitsu,Saigo, Kazuhiko,Ishida, Yasuhiro
, p. 127 - 131 (2015/02/02)
A practical method to prepare enantiopure 4,4,4-trifluoro-allo-threonine was developed by using an easily available fluorinated building block and a chiral auxiliary as starting materials. Trifluoroacetic anhydride was annulated with a ketene, derived fro
CARBACEPHEM BETA-LACTAM ANTIBIOTICS
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Page/Page column 57-58, (2010/04/06)
Carbacephem β-lactam antibiotics having structure (I) are disclosed, including stereoisomers, pharmaceutically acceptable salts, esters and prodrugs thereof, wherein Ar2, X, R1 and R2 are as defined herein. The compounds are useful for the treatment of bacterial infections, in particular those caused by methicillin-resistant Staphylococcus spp.
CARBACEPHEM β-LACTAM ANTIBIOTICS
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Page/Page column 62, (2010/04/06)
Carbacephem -lactam antibiotics having structure (I) are disclosed, including stereoisomers, pharmaceutically acceptable salts, esters and prodrugs thereof, wherein Ar1, Ar2, R1 and R2 are as defined herein. The compounds are useful for the treatment of bacterial infections, in particular those caused by methicillin-resistant Staphylococcus spp.
CARBACEPHEM BETA-LACTAM ANTIBIOTICS
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Page/Page column 52, (2010/11/05)
Carbacephem β-lactam antibiotics having chemical structures (I) and (II) are disclosed: including stereoisomers, pharmaceutically acceptable salts, esters and prodrugs thereof, wherein Ar2, R1, R2 and R6 are as defined herein. The compounds are useful for the treatment of bacterial infections, in particular those caused by methicillin-resistant Staphylococcus spp.
CARBACEPHEM β-LACTAM ANTIBIOTICS
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Page/Page column 75-76, (2009/05/30)
Carbacephem β-lactam antibiotics having the following chemical structures (I) and (II) are disclosed, including stereoisomers, pharmaceutically acceptable salts, esters and prodrugs thereof, wherein Ar2, R1, R2 and R3 are as defined herein. The compounds are useful for the treatment of bacterial infections, in particular those caused by methicillin-resistant Staphylococcus spp.
A contribution to the asymmetric synthesis of 3-amine β-lactams: The diastereoselective [2+2] cycloaddition reaction of chiral aminoketene equivalents with enolizable aldehyde-derived/mines
Palomo, Claudio,Aizpurua, Jesus M.,Legido, Marta,Mielgo, Antonia,Galarza, Regina
, p. 1432 - 1441 (2007/10/03)
N-[Bis(trimethylsilyl)methyl]imines 9 show unique chemical properties when compared with conventional imines. Their reaction with optically pure aminoketenes derived from dehydrochlorination of 14 and 15 affords the corresponding 3-amino-4-alkyl-β-lactams