19851-01-5

Basic information

• Product Name: 3-MORPHOLIN-4-YL-PROPIONALDEHYDE
• Synonyms: 3-MORPHOLIN-4-YL-PROPIONALDEHYDE;4-morpholinepropanal
• CAS NO: 19851-01-5
• Molecular Formula: C₇H₁₃NO₂
• Molecular Weight: 143.18
• Mol File: 19851-01-5.mol

Chemical Properties

• Boiling Point: 129-130 °C(Press: 10 Torr)
• Appearance: /
• Density: 1.023±0.06 g/cm3(Predicted)
• PKA: 6.66±0.10(Predicted)
• CAS DataBase Reference: 3-MORPHOLIN-4-YL-PROPIONALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-MORPHOLIN-4-YL-PROPIONALDEHYDE(19851-01-5)
• EPA Substance Registry System: 3-MORPHOLIN-4-YL-PROPIONALDEHYDE(19851-01-5)

Safety Data

• Hazardous Substances Data: 19851-01-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Morpholin-4-yl-propionaldehyde is used as an intermediate for the production of pharmaceuticals, contributing to the development of new medications and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Morpholin-4-yl-propionaldehyde serves as an intermediate, playing a crucial role in the synthesis of agrochemicals that aid in crop protection and enhancement of agricultural productivity.
Used in Fragrance Industry:
3-Morpholin-4-yl-propionaldehyde is utilized as a fragrance ingredient in perfumes and personal care products, adding to the complex blend of scents that create unique and appealing fragrances.
Used in Food Industry:
As a flavoring agent, 3-Morpholin-4-yl-propionaldehyde is employed in the food industry to enhance the taste and aroma of various food products, contributing to a more enjoyable culinary experience.

Upstream product

• 4441-30-9 3-morpholin-4-ylpropan-1-ol 
• 110-91-8 morpholine 
• 107-02-8 acrolein 

Downstream Products

• 1160360-60-0 3-tert-butyl-5-((4-fluorobenzyl)(3-morpholinopropyl)amino)-1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 

Relevant articles and documents

Chroman-4-one- and chromone-based sirtuin 2 inhibitors with antiproliferative properties in cancer cells

Sirtuins (SIRTs) catalyze the NAD+-dependent deacetylation of Nε-acetyl lysines on various protein substrates. SIRTs are interesting drug targets as they are considered to be related to important pathologies such as inflammation and aging-associated diseases. We have previously shown that chroman-4-ones act as potent and selective inhibitors of SIRT2. Herein we report novel chroman-4-one and chromone-based SIRT2 inhibitors containing various heterofunctionalities to improve pharmacokinetic properties. The compounds retained both high SIRT2 selectivity and potent inhibitory activity. Two compounds were tested for their antiproliferative effects in breast cancer (MCF-7) and lung carcinoma (A549) cell lines. Both compounds showed antiproliferative effects correlating with their SIRT2 inhibition potency. They also increased the acetylation level of α-tubulin, indicating that SIRT2 is likely to be the target in cancer cells. A binding mode of the inhibitors that is consistent with the SAR data was proposed based on a homology model of SIRT2.

Oxidation of alcohols by montmorillonite K-10 supported Bis(trimethylsilyl)chromate

Bis(Xtrimethylsilyl)chromate generated from chromic anhydride and hexamethyldisiloxane in dichloromethane was applied onto a montmorillonite K-10 surface. This reagent proved to be suitable for oxidizing alcohols of various types to the corresponding carbonyl compounds.