198969-19-6

Basic information

• Product Name: (2R,4R)-4-Phenoxy-1,2-pyrrolidinedicarboxylic acid1-(1,1-dimethylethyl)-2-methylester
• Synonyms: (2R,4R)-4-Phenoxy-1,2-pyrrolidinedicarboxylic acid1-(1,1-dimethylethyl)-2-methylester;1,2-Pyrrolidinedicarboxylic acid, 4-phenoxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4R)-;(2R,4R)-1-Boc-2-Methyl-4-phenoxypyrrolidine-2-carboxylic acid
• CAS NO: 198969-19-6
• Molecular Formula: C₁₇H₂₃NO₅
• Molecular Weight: 321.36822
• Mol File: 198969-19-6.mol

Chemical Properties

• Boiling Point: 411.654°C at 760 mmHg
• Flash Point: 202.761°C
• Appearance: /
• Density: 1.173g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.526
• CAS DataBase Reference: (2R,4R)-4-Phenoxy-1,2-pyrrolidinedicarboxylic acid1-(1,1-dimethylethyl)-2-methylester(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4R)-4-Phenoxy-1,2-pyrrolidinedicarboxylic acid1-(1,1-dimethylethyl)-2-methylester(198969-19-6)
• EPA Substance Registry System: (2R,4R)-4-Phenoxy-1,2-pyrrolidinedicarboxylic acid1-(1,1-dimethylethyl)-2-methylester(198969-19-6)

Safety Data

• Hazardous Substances Data: 198969-19-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Ramipril is used as an antihypertensive and heart failure treatment for managing high blood pressure and improving the heart's ability to pump blood effectively. It functions by inhibiting the ACE enzyme, leading to relaxation of blood vessels and reduced fluid retention in the body.
Common side effects of Ramipril include dizziness, cough, and increased blood potassium levels. It is important to consult a healthcare professional before using this medication, as it may interact with other drugs or medical conditions.

InChI:InChI=1/C17H23NO5/c1-17(2,3)23-16(20)18-11-13(10-14(18)15(19)21-4)22-12-8-6-5-7-9-12/h5-9,13-14H,10-11H2,1-4H3/t13-,14-/m1/s1

Upstream product

• 135042-17-0 (2R,4S)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 
• 108-95-2 phenol 

Downstream Products

• 198968-94-4 (2R,4R)-4-Phenoxy-pyrrolidine-2-carboxylic acid methyl ester 
• 198968-77-3 (2R,4R)-1-[2-(Adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionyl]-4-phenoxy-pyrrolidine-2-carboxylic acid methyl ester 

Relevant articles and documents

PYRROLIDINE GPR40 MODULATORS

The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.

Synthesis and biological properties of new constrained CCK-B antagonists: Discrimination of two affinity states of the CCK-B receptor on transfected CHO cells

To improve our knowledge of the bioactive conformation of CCK-B antagonists, we have developed a new series of constrained dipeptoids whose synthesis and biochemical properties are reported here. These compounds, of general structure N(α)-[(2-adamantyloxy