The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
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Paragraph 00204
(2014/06/11)
Synthesis and biological properties of new constrained CCK-B antagonists: Discrimination of two affinity states of the CCK-B receptor on transfected CHO cells
To improve our knowledge of the bioactive conformation of CCK-B antagonists, we have developed a new series of constrained dipeptoids whose synthesis and biochemical properties are reported here. These compounds, of general structure N(α)-[(2-adamantyloxy
Bellier, Bruno,McCort-Tranchepain, Isabelle,Ducos, Bertrand,Danascimento, Sophie,Meudal, Hervé,Noble, Florence,Garbay, Christiane,Roques, Bernard P.
p. 3947 - 3956
(2007/10/03)
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