199103-27-0

Basic information

• Product Name: Benzaldehyde,4-(4-piperidinyloxy)-
• Synonyms: 4-[(Piperidin-4-yl)oxy]benzaldehyde;4-(4-Piperidyloxy)benzaldehyde
• CAS NO: 199103-27-0
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.253
• Mol File: 199103-27-0.mol

Chemical Properties

• Boiling Point: 358.4 °C at 760 mmHg
• Flash Point: 170.5 °C
• Appearance: /
• Density: 1.117 g/cm³
• CAS DataBase Reference: Benzaldehyde,4-(4-piperidinyloxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde,4-(4-piperidinyloxy)-(199103-27-0)
• EPA Substance Registry System: Benzaldehyde,4-(4-piperidinyloxy)-(199103-27-0)

Safety Data

• Hazardous Substances Data: 199103-27-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
Benzaldehyde,4-(4-piperidinyloxy)is used as a building block in organic synthesis for its unique properties and reactivity.
Used in Pharmaceutical Production:
Benzaldehyde,4-(4-piperidinyloxy)is used as a key intermediate in the production of pharmaceuticals due to its potential as a precursor to various biologically active compounds.
Used in Fragrance Industry:
Benzaldehyde,4-(4-piperidinyloxy)is used as a key intermediate in the production of fragrances, taking advantage of its unique properties and reactivity.
Used in Specialty Chemicals:
Benzaldehyde,4-(4-piperidinyloxy)is used in the production of specialty chemicals, where its unique properties and reactivity are valuable.
Used in Medicinal Chemistry:
Benzaldehyde,4-(4-piperidinyloxy)has been studied for its potential as a precursor to various biologically active compounds, making it an important molecule in the field of medicinal chemistry.

Upstream product

• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 207798-38-7 4-(4-formylphenoxy)piperidine-1-carboxylic acid t-butyl ester 
• 118811-07-7 tert-butyl 4-(tosyloxy)piperidin-1-carboxylate 
• 123-08-0 4-hydroxy-benzaldehyde 
• 5382-16-1 4-HYDROXYPIPERIDINE 

Downstream Products

• 1404097-23-9 4-(1-nicotinoylpiperidin-4-yloxy)benzaldehyde 
• 1404097-22-8 4-(1-picolinoylpiperidin-4-yloxy)benzaldehyde 
• 1404097-26-2 4-(1-(5-chloropicolinoyl)piperidin-4-yloxy)benzaldehyde 
• 1404097-28-4 4-(1-(3-(trifluoromethyl)benzoyl)piperidin-4-yloxy)benzaldehyde 
• 1404097-29-5 4-(1-(3-fluoro-4-(trifluoromethyl)benzoyl)piperidin-4-yloxy)benzaldehyde 
• 1404097-30-8 4-(1-(4-(difluoromethoxy)benzoyl)piperidin-4-yloxy)benzaldehyde 
• 1404097-25-1 4-(1-(2-chloronicotinoyl)piperidin-4-yloxy)benzaldehyde 
• 1404097-31-9 4-(1-(4-nitropyridin-2-yl)piperidin-4-yloxy)benzaldehyde 
• 1404097-32-0 4-(1-(5-nitropyridin-2-yl)piperidin-4-yloxy)benzaldehyde 
• 1404097-33-1 2-(4-(4-formylphenoxy)piperidin-1-yl)nicotinonitrile 
• 1404097-34-2 4-(1-(3-(trifluoromethyl)pyridin-2-yl)piperidin-4-yloxy)benzaldehyde 
• 1404097-48-8 4-(1-(5-methylpyrazine-2-carbonyl)piperidin-4-yloxy)benzaldehyde 
• 1404097-49-9 4-(1-(4-chloro-2-methoxybenzoyl)piperidin-4-yloxy)benzaldehyde 
• 1404097-50-2 4-(1-(4-fluorophenylsulfonyl)piperidin-4-yloxy)benzaldehyde 

Relevant articles and documents

Synthesis and biological evaluation of 5-benzylidenepyrimidine-2,4,6(1H,3H, 5H)-trione derivatives for the treatment of obesity-related nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD), one of chronic liver diseases, seems to be rising as the obesity epidemic continues. In this study, 54 novel (thio)barbituric acid derivatives have been synthesized and evaluated for pharmacological activity. 7h exhibited potent glucose-lowering effects on insulin-resistant HepG2 cells and regulated adiponectin and leptin expression in 3T3-L1 adipocytes. Oral administration of 7h at 25 mg kg-1 day -1 for 4 weeks improved the progression of high fat diet-induced NAFLD by reducing the weight of body, liver, and fat, as well as modulating serum levels of fasting glucose, insulin, triglycerides, LDL-c, ALT, adiponectin and hepatic contents of triglycerides, total cholesterol. H&E stainings revealed that 7h blocked fat deposition in liver and the increase of adipocyte number and size in adipose tissues from NAFLD. Furthermore, treatment with 7h alleviated the obese clinical symptoms, recovered serum biomarkers to appropriate ranges, and improved glucose tolerance by OGTT and IGTT in DIO mice.

2-Aryl benzimidazoles featuring alkyl-linked pendant alcohols and amines as inhibitors of checkpoint kinase Chk2

A series of benzimidazole compounds containing pendant alcohol and amine moieties was found to be active against checkpoint kinase Chk2. These compounds were prepared to examine a potential hydrogen bond interaction with an active site residue and to inve