19920-84-4

Basic information

• Product Name: 1-Bromo-3-cyclohexylbenzene
• Synonyms: 1-Bromo-3-cyclohexylbenzene
• CAS NO: 19920-84-4
• Molecular Formula: C₁₂H₁₅Br
• Molecular Weight: 239.1515
• Mol File: 19920-84-4.mol

Chemical Properties

• Boiling Point: 289.2±19.0 °C(Predicted)
• Appearance: /
• Density: 1.280±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-Bromo-3-cyclohexylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Bromo-3-cyclohexylbenzene(19920-84-4)
• EPA Substance Registry System: 1-Bromo-3-cyclohexylbenzene(19920-84-4)

Safety Data

• Hazardous Substances Data: 19920-84-4(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
1-Bromo-3-cyclohexylbenzene is used as a building block for the synthesis of various organic compounds, leveraging its reactivity in a wide range of chemical reactions such as nucleophilic substitution and palladium-catalyzed cross-coupling reactions.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-Bromo-3-cyclohexylbenzene is used as a key intermediate in the development of pharmaceuticals, contributing to the creation of new drugs and therapeutic agents.
Used in Chemical Research:
1-Bromo-3-cyclohexylbenzene is also utilized in chemical research for studying reaction mechanisms and exploring new synthetic pathways, further expanding the scope of organic chemistry.

Upstream product

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Downstream Products

• 57263-47-5 1-(4-cyclohexyl-phenyl)-2,2,4,4-tetramethyl-3-(4-phenyl-piperazin-1-yl)-cyclobutanol 

Relevant articles and documents

Modular Generation of (Iodinated) Polyarenes Using Triethylgermane as Orthogonal Masking Group

While the modular construction of molecules from suitable building blocks is a powerful means to more rapidly generate a diversity of molecules than through customized syntheses, the further evolution of the underlying coupling methodology is key to realize widespread applications. We herein disclose a complementary modular coupling approach to the widely employed Suzuki coupling strategy of boron containing precursors, which relies on organogermane containing building blocks as key orthogonal functionality and an electrophilic (rather than nucleophilic) unmasking event paired with air-stable PdI dimer based bond construction. This allows to significantly shorten the reaction times for the iterative coupling steps and/or to close gaps in the accessible compound space, enabling straightforward access also to iodinated compounds.

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