199929-31-2

Basic information

• Product Name: 3-hydroxy-N-p-tolylpropanamide
• Synonyms: 3-hydroxy-N-p-tolylpropanamide;3-Hydroxy-N-(4-methylphenyl)propanamide;p-Hydracrylotoluidide
• CAS NO: 199929-31-2
• Molecular Formula: C10H13NO2
• Molecular Weight: 179
• Mol File: 199929-31-2.mol

Chemical Properties

• Appearance: /
• Density: 1.172
• CAS DataBase Reference: 3-hydroxy-N-p-tolylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-N-p-tolylpropanamide(199929-31-2)
• EPA Substance Registry System: 3-hydroxy-N-p-tolylpropanamide(199929-31-2)

Safety Data

• Hazardous Substances Data: 199929-31-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-hydroxy-N-p-tolylpropanamide is used as a muscle relaxant for the treatment of conditions characterized by muscle spasms and spasticity. Its mechanism of action involves the blockade of voltage-gated sodium channels, leading to reduced nerve impulse conduction and muscle relaxation.
3-hydroxy-N-p-tolylpropanamide is also used as an analgesic for managing chronic pain. Its effectiveness in this application is attributed to its impact on nerve impulse transmission, which helps alleviate pain sensations.
Used in Neurological Treatments:
In the context of neurological conditions, 3-hydroxy-N-p-tolylpropanamide is utilized to alleviate symptoms associated with spasticity and other nerve-related disorders. Its well-tolerated profile and minimal side effects make it a preferred option for patients requiring long-term management of such conditions.
Used in Combination Therapies for Pain Management:
3-hydroxy-N-p-tolylpropanamide is employed in combination therapies for the treatment of various neuropathic pain syndromes. Its synergistic effects with other medications enhance the overall therapeutic outcome, providing more effective pain relief for patients suffering from these syndromes.

Upstream product

• 57-57-8 β-Propiolactone 
• 106-49-0 p-toluidine 
• 15258-46-5 N-allyl-p-toluidine 
• 503-66-2 3-hydroxypropionic acid 
• 637-27-4 phenyl propionate 
• 38491-60-0 β-phenyl hydroxypropionate 

Relevant articles and documents

CATALYST FOR CONVERTING ESTER TO AMIDE USING HYDROXYL GROUP AS ORIENTATION GROUP

Provided is a method for amidating a hydroxy ester compound at a high chemical selectivity. The amidation reaction method for a hydroxy ester compound comprises, in the presence of a catalyst containing a compound of a transition metal of the group 4 or group 5 in the periodic table, reacting at least one kind of hydroxy ester compound selected from the group consisting of an α-hydroxy ester compound, a β-hydroxy ester compound, a γ-hydroxy ester compound and a δ-hydroxy ester compound with an amino compound so as to amidate an ester group having a hydroxyl group at the α-, β-, γ- or δ-position of the hydroxy ester compound.

Hydroxy Group Directed Catalytic Hydrosilylation of Amides

Chemo- and site-selective hydrosilylation of α- or β-hydroxy amides using organocatalyst B(C6F5)3 and commercially available hydrosilanes is described. This transformation is operative under mild conditions and tolerates a wide range of functional groups. The reaction was applied for selective reduction of a specific amide group of the therapeutically important cyclic peptide cyclosporin A, demonstrating the potential usefulness of this catalytic method in late-stage structural transformations of drug lead molecules.

An Unexpected Construction of 2-Arylquinolines from N-Cinnamylanilines through sp3 Ci-H Aerobic Oxidation Induced by a Catalytic Radical Cation Salt

An unexpected reaction of cinnamylanilines was achieved through the radical cation salt-induced aerobic oxidation of sp3 C-H bonds, providing a series of 2-arylquinolines. The mechanistic study shows that the cinnamylaniline was oxidized to an imine, which was attacked by the aniline generated through decomposition of the corresponding imine. After further intramolecular cyclization and aromatization, 2-arylquinolines were obtained. This reaction provides a new method to construct 2-arylquinolines from readily accessible starting materials.