20195-13-5

Basic information

• Product Name: diethyl octyl phosphate
• Synonyms: AHCSHBOAPHEPDO-UHFFFAOYSA-N;Phosphoric Acid Diethyl Octyl Ester
• CAS NO: 20195-13-5
• Molecular Formula: C₁₂H₂₇O₄P
• Molecular Weight: 266.3141
• Mol File: 20195-13-5.mol

Chemical Properties

• Boiling Point: 288.3°C at 760 mmHg
• Flash Point: 142.1°C
• Density: 0.986g/cm³
• Vapor Pressure: 0.00409mmHg at 25°C
• Refractive Index: 1.43
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: diethyl octyl phosphate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl octyl phosphate(20195-13-5)
• EPA Substance Registry System: diethyl octyl phosphate(20195-13-5)

Safety Data

• Hazardous Substances Data: 20195-13-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Diethyl octyl phosphate is used as a penetration enhancer for transdermal drug delivery systems. It facilitates the passage of drugs through the skin, allowing for more effective and efficient administration of medications.
Used in Chemical Synthesis:
Diethyl octyl phosphate is used as a reagent in the preparation of trialkyl phosphate, which is an important intermediate in the synthesis of various chemical compounds and materials.
Used in Pesticide Industry:
Diethyl octyl phosphate is used as a reagent in the synthesis of phosphorothiolate anticholinesterases, which are a class of pesticides that inhibit the enzyme acetylcholinesterase in insects, leading to their paralysis and death. This makes it a valuable component in the development of effective insecticides.

Upstream product

• 17158-60-0 sodium octanolate 
• 814-49-3 diethyl chlorophosphate 
• 111-87-5 octanol 
• 762-04-9 phosphonic acid diethyl ester 
• 53121-41-8 octyl phosphorodichloridate 
• 141-52-6 sodium ethanolate 

Relevant articles and documents

GELLED HYDROCARBONS FOR OILFIELD PROCESSES, PHOSPHATE ESTER COMPOUNDS USEFUL IN GELLATION OF HYDROCARBONS AND METHODS FOR PRODUCTION AND USE THEREOF

Phosphate esters useful for gelling hydrocarbons in combination with a metal source are disclosed along with methods of preparation of the phosphate esters. Fouling in oil refinery towers has been attributed due to distillation of impurities present in phosphate esters used to gel hydrocarbons for oil well fracturing. The improved method of preparation of the phosphate ester results in a product that substantially reduces or eliminates volatile phosphorus, which is phosphorus impurities that distill up to 250° C., and increases the high temperature viscosity of the hydrocarbon gels formed using the phosphate esters.

An improved method for Lewis acid catalyzed phosphoryl transfer with Ti(t-BuO)4

Several inorganic esters have been evaluated as phosphoryl transfer catalysts. Of these, Ti(t-BuO)4 was found to be the most effective catalyst giving excellent yields of the desired phosphate esters. The loading of the catalyst could be reduced to a little as 5 mol % for a majority of substrates with no loss in the yield of product. This methodology is significantly more versatile than using TiCl4 and is suitable for the phosphorylation of more complex carbohydrates and molecules of biological interest.

Synthesis of mixed alkylphosphites and alkylphosphates

Some mixed phosphites having two different alkyl chain were obtained as forerunners for mixed phosphates Mixed dialkyl phosphates were obtained in good yields (40-80%) by phase transfer catalysis in liquid-liquid sistem, starting from different dialkyl phosphites and aliphatic alcohols. The reaction conditions were optimized in order to obtain good yields in phosphites and phosphates respectively. Compounds were analyzed by IR, P31-NMR.