diethyl octyl phosphate

Base Information

• Chemical Name: diethyl octyl phosphate
• CAS No.: 20195-13-5
• Molecular Formula: C12H27O4P
• Molecular Weight: 266.3141
• Mol file: 20195-13-5.mol

Synonyms:Ethyl octyl phosphate;n-octyl diethyl phosphate;Phosphoric acid,diethyl octyl ester;phosphoric acid diethyl ester-octyl ester;Octyl diethyl phosphate;Phosphorsaeure-diaethylester-octylester;

Chemical Property of diethyl octyl phosphate

Chemical Property:

• Vapor Pressure: 0.00409mmHg at 25°C
• Boiling Point: 288.3°C at 760 mmHg
• Flash Point: 142.1°C
• PSA: 54.57000
• Density: 0.986g/cm³
• LogP: 4.54460
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly)

Purity/Quality:

PhosphoricAcidDiethylOctylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Phosphoric acid diethyl octyl ester is part of a group of phosphate derivatives that enhance drug penetration through the skin. Phosphoric acid diethyl octyl ester is also used as a reagent to prepare trialkyl phosphate and phosphorothiolate anticholinesterases.

Technology Process of diethyl octyl phosphate

There total 6 articles about diethyl octyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

octanol (111-87-5) + diethyl chlorophosphate (814-49-3) → n-octyl diethyl phosphate (20195-13-5)

Guidance literature:

With titanium(IV) tetrabutoxide; triethylamine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/jo034331g

Reference yield: 45.0%

octanol (111-87-5) + phosphonic acid diethyl ester (762-04-9) → n-octyl diethyl phosphate (20195-13-5)

Guidance literature:

With sodium hydroxide; tetrabutylammomium bromide; In tetrachloromethane; dichloromethane; at 15 ℃; for 3h;

DOI:10.1080/10426500307865

Reference yield:

octyl phosphorodichloridate (53121-41-8) + sodium ethanolate (141-52-6) → n-octyl diethyl phosphate (20195-13-5)

Guidance literature:

In diethyl ether; at 20 ℃; for 1h; Cooling with ice;

upstream raw materials:

sodium octanolate

diethyl chlorophosphate

octanol

phosphonic acid diethyl ester