20357-22-6

Basic information

• Product Name: 4-Methyl-2-nitrobenzaldehyde
• Synonyms: 4-METHYL-2-NITROBENZALDEHYDE;2-Nitro-4-methylbenzaldehyde
• CAS NO: 20357-22-6
• Molecular Formula: C₈H₇NO₃
• Molecular Weight: 165.15
• Mol File: 20357-22-6.mol

Chemical Properties

• Boiling Point: 309.4 °C at 760 mmHg
• Flash Point: 154.9 °C
• Appearance: /
• Density: 1.278 g/cm³
• Vapor Pressure: 0.000642mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-Methyl-2-nitrobenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methyl-2-nitrobenzaldehyde(20357-22-6)
• EPA Substance Registry System: 4-Methyl-2-nitrobenzaldehyde(20357-22-6)

Safety Data

• Hazardous Substances Data: 20357-22-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Methyl-2-nitrobenzaldehyde is used as an intermediate in the synthesis of various pharmaceuticals. Its role in creating complex organic molecules makes it valuable for developing new drugs and improving existing ones.
Used in Dye and Perfume Industry:
4-Methyl-2-nitrobenzaldehyde is utilized as a key ingredient in the production of dyes and perfumes, where its chemical structure contributes to the color and fragrance of the final products.
Used in Agrochemical Production:
4-Methyl-2-nitrobenzaldehyde is used as a precursor in the manufacturing of agrochemicals, playing a crucial role in the development of pesticides and other agricultural chemicals that protect crops and enhance yields.
Used in Specialty Chemicals Manufacturing:
As a key intermediate, 4-Methyl-2-nitrobenzaldehyde is also involved in the production of specialty chemicals, which are used in a wide range of applications, from coatings to plastics.
Used in Medicinal Chemistry Research:
4-Methyl-2-nitrobenzaldehyde is studied for its potential anti-cancer and anti-inflammatory properties, making it an important compound in the field of medicinal chemistry. Its study may lead to the discovery of new therapeutic agents.
Safety Note:
Due to its toxic nature, 4-Methyl-2-nitrobenzaldehyde should be handled with care, preferably in a well-ventilated area to minimize health risks associated with its use.

InChI:InChI=1/C8H7NO3/c1-6-2-3-7(5-10)8(4-6)9(11)12/h2-5H,1H3

Upstream product

• 50-00-0 formaldehyd 
• 89-62-3 4-methyl-2-nitroaniline 
• 17343-70-3 1,1-dichloro-2-(4-methylphenyl)cyclopropane 
• 22996-24-3 (4-methyl 2-nitro-phenyl)-methanol 
• 7325-46-4 1,4-phenylenediacetic acid 
• 1455471-51-8 2,2'-(2-nitro-1,4-phenylene)diacetic acid 
• 27329-27-7 4-methyl-2-nitrobenzoic acid 
• 20587-29-5 methyl 4-methyl-2-nitrobenzoate 
• 75-17-2 formaldoxime 

Downstream Products

• 20357-33-9 4-methyl-2-nitro-trans-cinnamic acid 
• 143883-00-5 13-(4-Methyl-2-nitro-phenyl)-12,13-dihydro-7,12,13a-triaza-benzo[hi]chrysene 
• 59236-38-3 2-amino-4-methylbenzaldehyde 
• 22996-24-3 (4-methyl 2-nitro-phenyl)-methanol 
• 143883-05-0 13-(4-Methyl-2-nitro-phenyl)-7,12,13a-triaza-benzo[hi]chrysene 
• 109466-90-2 11-methyl-20(RS)-camptothecin 
• 103204-27-9 2-amino-4-methyl-trans-cinnamic acid 
• 170990-43-9 ethyl 4-hydroxy-4(4-methyl-2-nitrophenyl)-2-butynoate 
• 105910-05-2 3-(4-methyl-2-nitrophenyl)acrylic acid ethyl ester 
• 1313592-01-6 methyl 1-[4-(1-methoxy-1-oxopropan-2-yl)-3-nitrobenzyl]-2-oxocyclopentanecarboxylate 
• 1313592-04-9 sodium 2-{2-nitro-4-[(2-oxocyclopentyl)methyl]phenyl}propanoate 
• 916845-88-0 methyl 2-(4-methyl-2-nitrophenyl)propanoate 
• 29640-90-2 (4-methyl-2-nitro-phenyl)-acetic acid 
• 29640-91-3 methyl 2-(4-methyl-2-nitrophenyl)acetate 

Relevant articles and documents

Compound with dual inhibitory activity TDO, IDOO1 and application of compound for treating neurodegenerative disease (by machine translation)

The present invention provides a compound of formula I, or a pharmaceutically acceptable salt thereof, or a solvate thereof, which can selectively inhibit TDO, IDOO1, which has a significant inhibitory effect on TDO and/or IDOO1. In addition, the prepared compound has a remarkable anti-tumor effect, has a certain treatment effect on's disease and's disease, and has a good application prospect in the field of medicine preparation. (by machine translation)

MOF Decomposition and Introduction of Repairable Defects Using a Photodegradable Strut

Photoswitchable components can modulate the properties of metal organic frameworks (MOFs); however, photolabile building blocks remain underexplored. A new strut NPDAC (2-nitro-1,4-phenylenediacetic acid) that undergoes photodecarboxylation has been prepared and incorporated into a MOF, using post-synthetic linker exchange (PSLE) from the structural analogue containing PDAC (p-phenylenediacetic acid). Irradiation of NPDAC-MOF leads to MOF decomposition and concomitant formation of amorphous material. In addition to complete linker exchange, MOFs containing a mixture of PDAC and NPDAC can be obtained through partial linker exchange. In NPDAC30-MOF, which contains approximately 30 % NPDAC, the MOF retains crystallinity after irradiation, but the MOF contains defect sites consistent with loss of decarboxylated NPDAC linkers. The defect sites can be repaired by exposure to additional PDAC or NPDAC linkers at a much faster rate than the initial exchange process. The photoremoval and replacement process may lead to a more general approach to customizable MOF structures.

Novel access to carbonyl and acetylated compounds: The role of the tetra-: N -butylammonium bromide/sodium nitrite catalyst

A novel aerobic oxidation of alcohols without the use of any oxidants was developed. An equimolar catalytic mixture of tetra-n-butylammonium bromide and sodium nitrite catalyzes the aerobic selective oxidation of benzylic alcohols under oxidant-free, base-free and metal-free conditions. The mild reaction conditions allow oxidation of a wide range of benzylic alcohols, chemo-selectively to their carbonyl compounds (68-93% isolated yields). More importantly, high selectivity among different kinds of alcohols (aromatic vs. aliphatic alcohols, primary vs. secondary alcohols as well as alcohols having neutral rings vs. electron-deficient rings) is available by this approach. The method surprisingly switched over to be an efficient acetylation approach in the case of aliphatic alcohols without the use of any transition metal, phosphorous or other toxic reagents or any need for using toxic acyl halides, sulfonyl halides, anhydrides, etc. by the use of only acetic acid as a reagent.

Synthesis and biological evaluation of loxoprofen derivatives

Non-steroidal anti-inflammatory drugs (NSAIDs) achieve their anti-inflammatory actions through an inhibitory effect on cyclooxygenase (COX). Two COX subtypes, COX-1 and COX-2, are responsible for the majority of COX activity at the gastrointestinal mucosa and in tissues with inflammation, respectively. We previously suggested that both gastric mucosal cell death due to the membrane permeabilization activity of NSAIDs and COX-inhibition at the gastric mucosa are involved in NSAID-induced gastric lesions. We have also reported that loxoprofen has the lowest membrane permeabilization activity among the NSAIDs we tested. In this study, we synthesized a series of loxoprofen derivatives and examined their membrane permeabilization activities and inhibitory effects on COX-1 and COX-2. Among these derivatives, 2-{4′-hydroxy-5-[(2-oxocyclopentyl)methyl]biphenyl-2-yl}propanoate 31 has a specificity for COX-2 over COX-1. Compared to loxoprofen, oral administration of 31 to rats produced fewer gastric lesions but showed an equivalent anti-inflammatory effect. These results suggest that 31 is likely to be a therapeutically beneficial and safer NSAID.

COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE

Compounds of formula (I) or a salt thereof are provided: wherein R4, R5, R6, Q, A, Y and R are as defined in the description. Uses of the compounds as medicaments and in the manufacture of medicaments for treating psychotic disorders, cognitive impairments and Alzheimer's Disease are disclosed. The invention further discloses pharmaceutical compositions comprising the compounds.

Oxidation of alcohols by silica gel-supported bis (trimethylsilyl) chromate under microwave irradiation without solvent

Microwave irradiation of alcohols with silica gel-supported bis (trimethylsilyl) chromate in dry media provides a fast, effecient and simple method for oxidation of alcohols to corresponding carbonyl compounds.

Oxidation of alcohols by montmorillonite K-10 supported Bis(trimethylsilyl)chromate

Bis(Xtrimethylsilyl)chromate generated from chromic anhydride and hexamethyldisiloxane in dichloromethane was applied onto a montmorillonite K-10 surface. This reagent proved to be suitable for oxidizing alcohols of various types to the corresponding carbonyl compounds.

Nitration of 2-Aryl-1,1-dichlorocyclopropanes

A series of 2-aryl-1,1-dichlorocyclopropanes were nitrated with a mixture of nitric acid and sulfuric acid.The results suggest that an electron-withdrawing group on the phenyl ring and gem-dihalogens on the cyclopropane ring are essential for isoxazole formation.

Plant antitumor agents. 25. Total synthesis and antileukemic activity of ring a substituted camptothecin analogues. Structure-activity correlations

Nineteen racemic ring A substituted analogues of the antitumor agent 20(S)-camptothecin were prepared by total synthesis and evaluated for in vitro cytotoxic activity against KB cell culture and in vivo antileukemic activity against L1210. These compounds bore a wide variety of substitutents at C11 designed to confer upon the ring system a broad range of combinations of electronic, steric, and lipophilic effects. A few C10-substituted derivatives as well as C10,C11-disubstituted analogues prepared as part of a concurrent study have also been included for general comparison. With the notable exception of the cyano derivative, the 11-substituted compounds displayed only modest in vitro and in vivo activities, and there was a remarkable insensitivity toward the nature of the substituent. In contrast, the 9- and 10-substituted compounds exhibited a considerably higher level of dose potency and activity both in vitro and in vitro.