20364-30-1

Basic information

• Product Name: 4-METHYLPYRIDINE-N-OXIDE
• Synonyms: 1,2,3,4-Tetrahydro-2,2-dimethylquinoline
• CAS NO: 20364-30-1
• Molecular Formula: C₁₁H₁₅N
• Molecular Weight: 161.24
• Mol File: 20364-30-1.mol

Chemical Properties

• Boiling Point: 95-98 °C(Press: 2 Torr)
• Appearance: /
• Density: 0.944±0.06 g/cm3(Predicted)
• PKA: 5.22±0.40(Predicted)
• CAS DataBase Reference: 4-METHYLPYRIDINE-N-OXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYLPYRIDINE-N-OXIDE(20364-30-1)
• EPA Substance Registry System: 4-METHYLPYRIDINE-N-OXIDE(20364-30-1)

Safety Data

• Hazardous Substances Data: 20364-30-1(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
4-Methylpyridine-N-oxide is used as a reagent in organic synthesis for its ability to facilitate various chemical reactions, contributing to the formation of complex organic molecules.
Used as a Solvent in Chemical Reactions:
In the chemical industry, 4-Methylpyridine-N-oxide serves as a solvent, enhancing the efficiency of reactions by dissolving reactants and promoting their interaction.
Used in Pharmaceutical Production:
4-Methylpyridine-N-oxide is utilized as a precursor in the production of pharmaceuticals, playing a crucial role in the synthesis of various medicinal compounds.
Used in Pesticide Production:
4-METHYLPYRIDINE-N-OXIDE also finds application in agriculture as a precursor in the manufacturing of pesticides, contributing to the development of effective crop protection agents.
Used in Other Organic Compounds Production:
Beyond its applications in pharmaceuticals and pesticides, 4-Methylpyridine-N-oxide is employed in the synthesis of a range of other organic compounds, highlighting its versatility in the chemical industry.

Upstream product

• 1111-97-3 3-chloro-3-methylbut-1-yne 
• 62-53-3 aniline 
• 104177-71-1 o-isopentylaniline 
• 27125-61-7 2-(3-methylbut-2-en-1-yl)aniline 
• 60173-64-0 N-(1,1-dimethylprop-2-en-1-yl)aniline 
• 861216-48-0 tert-butyl 2-methylbut-3-en-2-yl carbonate 
• 870-63-3 prenyl bromide 
• 130074-91-8 2,2,2-trifluoro-N-<2-(3-methylbut-2-enyl)phenyl>acetamide 
• 2727-71-1 N-(2-bromophenyl)-2,2,2-trifluoroacetamide 
• 7471-09-2 3-methyl-3-phenylamino-1-butyne 
• 179898-87-4 1-tert-butoxycarbonyl-1,2,3,4-tetrahydro-2,2-dimethyl-4-quinolinone 
• 7553-56-2 iodine 
• 78-79-5 isoprene 
• 132588-91-1 1,2,3,4-tetrahydro-2,2-dimethylquinolin-4-one 

Downstream Products

• 179899-22-0 7-amino-1,2,3,4-tetrahydro-2,2-dimethylquinoline 
• 201541-36-8 1,2,3,4-tetrahydro-2,2-dimethyl-7-nitroquinoline 
• 88774-00-9 N-(2-trifluoromethylbenzoyl)-2,2-dimethyl-1,2,3,4-tetrahydroquinoline 

Relevant articles and documents

SUBSTITUTED, SATURATED AND UNSATURATED N-HETEROCYCLIC CARBOXAMIDES AND RELATED COMPOUNDS FOR THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS

The invention provides substituted, saturated and unsaturated N-heterocyclic carboxamides and related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., cancer, lysosomal storage disorder, neurodegenerative disorder, inflammatory disorder, in a patient.

Iron-Catalyzed Intramolecular Aminations of C(sp3)?H Bonds in Alkylaryl Azides

The nucleophilic iron complex Bu4N[Fe(CO)3(NO)] (TBA[Fe]) catalyzes the direct intramolecular amination of unactivated C(sp3)?H bonds in alkylaryl azides, which results in the formation of substituted indoline and tetrahydroquinoline derivatives.

Switching Androgen Receptor Antagonists to Agonists by Modifying C-Ring Substituents on Piperidinoquinolinone

New nonsteroidal human androgen receptor (hAR) agonists were developed from an hAR antagonist pharmacophore, 2(1H-piperidinoquinolinone. (+/-)-trans-7,8-diethyl-4-trifluoromethyl-2(1H)-piperidinoquinolinone was synthesized and demonstrated p

Synthesis and biological activity of a novel series of nonsteroidal, peripherally selective androgen receptor antagonists derived from 1,2- dihydropyridono[5,6-g]quinolines

A new nonsteroidal antiandrogenic pharmacophore has been discovered using cell-based cotransfection assays with human androgen receptor (hAR). This series of AR antagonists is structurally characterized by a linear tricyclic 1,2-dihydropyridono[5,6-g]quinoline core. Analogues inhibit AR- mediated reporter gene expression and bind to AR as potently as or better than any known AR antagonists. Several analogues also showed excellent in vivo activity in classic rodent models of AR antagonism, inhibiting growth of rat ventral prostate and seminal vesicles, without accompanying increases in serum gonadotropin and testosterone levels, as is seen with other AR antagonists. Investigations of structure - activity relationships surrounding this pharmacophore resulted in molecules with complete specificity for AR, antagonist activity on an AR mutant commonly observed in prostate cancer patients, and improved in vivo efficacy. Molecules based on this series of compounds have the potential to provide unique and effective clinical opportunities for treatment of prostate cancer and other androgen-dependent diseases.

Heterocyclic Syntheses Through Electrophilic Ring Closure Reactions of ortho-Allylaniline Systems

Amide derivatives of 2-allylanilines have been prepared by metallation of the amide derivatives of the corresponding 2-bromoanilines and subsequent reaction with an allylic halide.The electrophile-promoted cyclization of these compounds has been investiga

207. Photo-Emde Degradation of 1,2,3,4-Tetrahydroquinolinium Salts

It is shown that 1,1-dimethyl-1,2,3,4-tetrahydroquinolinium ions undergo, under direct irradiation through quartz in CH3OH and independent of the nature of the counterion (I-, BF4-), a reductive cleavage of the N(1)-C(8a) bond (photo-Emde degradation).The corresponding N,N-dimethyl-3-phenylpropylamines are formed in high yields and without contamination by Hofmann degradation products of the tetrahydroquinolinium salts.Me groups at C(2) as well as substituents at C(6) (CH3, Cl, CH3O) favour the photo-Emde degradation.The aromatic Cl-substituent is reductively split off in the course of the photoreaction.