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5,6-dichloro-3-nitropyridin-2-amine is a chemical compound characterized by its molecular formula C5H3Cl2N3O2. It is an aromatic amine with two chlorine atoms and a nitro group attached to a pyridine ring, which endows it with unique chemical properties and potential applications in various fields.

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  • 203794-33-6 Structure
  • Basic information

    1. Product Name: 5,6-dichloro-3-nitropyridin-2-aMine
    2. Synonyms: 5,6-dichloro-3-nitropyridin-2-aMine;5,6-dichloro-2-amino-3-nitropyridine;5,6-Dichloro-3-nitro-2-pyridinamine
    3. CAS NO:203794-33-6
    4. Molecular Formula: C5H3Cl2N3O2
    5. Molecular Weight: 208.00222
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 203794-33-6.mol
    9. Article Data: 2
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 347.1±37.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.723±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C(protect from light)
    8. Solubility: N/A
    9. PKA: -3.87±0.50(Predicted)
    10. CAS DataBase Reference: 5,6-dichloro-3-nitropyridin-2-aMine(CAS DataBase Reference)
    11. NIST Chemistry Reference: 5,6-dichloro-3-nitropyridin-2-aMine(203794-33-6)
    12. EPA Substance Registry System: 5,6-dichloro-3-nitropyridin-2-aMine(203794-33-6)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 203794-33-6(Hazardous Substances Data)

203794-33-6 Usage

Uses

Used in Pharmaceutical Synthesis:
5,6-dichloro-3-nitropyridin-2-amine is utilized as a key intermediate in the synthesis of pharmaceuticals. Its unique structure allows for the development of new drugs with specific therapeutic properties, making it a valuable component in medicinal chemistry.
Used in Agrochemical Synthesis:
In the agrochemical industry, 5,6-dichloro-3-nitropyridin-2-amine serves as a crucial building block for the creation of new pesticides and other agrochemicals. Its incorporation into these products can enhance their effectiveness in controlling pests and diseases in agriculture.
Used in Organic Chemistry Research:
5,6-dichloro-3-nitropyridin-2-amine also has potential applications as a building block in organic chemistry research. Its versatile structure allows for further functionalization and modification, enabling the exploration of new chemical reactions and the synthesis of novel organic compounds.
Safety Considerations:
Due to its toxic and potentially harmful properties, 5,6-dichloro-3-nitropyridin-2-amine is classified as a hazardous substance. It should be handled with care, following proper safety protocols to minimize risks to human health and the environment.

Check Digit Verification of cas no

The CAS Registry Mumber 203794-33-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,3,7,9 and 4 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 203794-33:
(8*2)+(7*0)+(6*3)+(5*7)+(4*9)+(3*4)+(2*3)+(1*3)=126
126 % 10 = 6
So 203794-33-6 is a valid CAS Registry Number.

203794-33-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 5,6-dichloro-3-nitropyridin-2-amine

1.2 Other means of identification

Product number -
Other names 2-Pyridinamine,5,6-dichloro-3-nitro

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:203794-33-6 SDS

203794-33-6Upstream product

203794-33-6Downstream Products

203794-33-6Relevant articles and documents

Design, synthesis and anti-HBV activity evaluation of new substituted imidazo[4,5-b]pyridines

Gerasi, Maria,Frakolaki, Efseveia,Papadakis, Georgios,Chalari, Anna,Lougiakis, Nikolaos,Marakos, Panagiotis,Pouli, Nicole,Vassilaki, Niki

, (2020/01/31)

The design and synthesis of a number of new imidazo[4,5-b]pyridines is described. The heterocyclic scaffold possesses 6-chloro- or 5,6-dichloro-substitution and bears various 2-alkylamino-methyl or ethyl groups. The corresponding N1 and N3-tosylates are also presented. The anti-HBV activity of the compounds was evaluated in HBV infectious system at the level of HBV rcDNA secretion and CC50, EC50 and selectivity index values were determined. The tosylates showed low antiviral potency and relatively high cytotoxicity, on the contrary, a number of 2,5 and/or-6-substituted imidazopyridines, mainly those belonging to the 6-chloroimidazo[4,5-b]pyridine series, were endowed with a very interesting profile and were further investigated. The most promising among them, along with the reduction of the secreted HBV rcDNA, also caused a reduction in HBV cccDNA and pgRNA levels, with a concomitant accumulation of the intracellular encapsidated rcDNA. Surprisingly, the most active 2-diethylaminoethyl-substituted derivative (21d), was highly competitive to interferon.

Synthesis of new imidazopyridine nucleoside derivatives designed as maribavir analogues

Papadakis, Georgios,Gerasi, Maria,Snoeck, Robert,Marakos, Panagiotis,Andrei, Graciela,Lougiakis, Nikolaos,Pouli, Nicole

, (2020/10/18)

The strong inhibition of Human Cytomegalovirus (HCMV) replication by benzimidazole nucleosides, like Triciribine and Maribavir, has prompted us to expand the structure-activity relationships of the benzimidazole series, using as a central core the imidazo[4,5-b]pyridine scafflold. We have thus synthesized a number of novel amino substituted imidazopyridine nucleoside derivatives, which can be considered as 4-(or 7)-aza-d-isosters of Maribavir and have evaluated their potential antiviral activity. The target compounds were synthesized upon glycosylation of suitably substituted 2-aminoimidazopyridines, which were prepared in six steps starting from 2-amino-6-chloropyridine. Even if the new compounds possessed only a slight structural modification when compared to the original drug, they were not endowed with interesting antiviral activity. Even so, three derivatives showed promising cytotoxic potential.

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