97941-89-4

Basic information

• Product Name: 2,3-Diamino-5,6-dichloropyridine
• Synonyms: 2,3-Diamino-5,6-dichloropyridine;5,6-dichloropyridine-2,3-diaMine;5,6-Dichloro-2,3-pyridinediaMine;5,6-dichloropyridin-2,3-diamine
• CAS NO: 97941-89-4
• Molecular Formula: C₅H₅Cl₂N₃
• Molecular Weight: 178.0193
• Mol File: 97941-89-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 167℃ (water )
• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2,3-Diamino-5,6-dichloropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Diamino-5,6-dichloropyridine(97941-89-4)
• EPA Substance Registry System: 2,3-Diamino-5,6-dichloropyridine(97941-89-4)

Safety Data

• Hazardous Substances Data: 97941-89-4(Hazardous Substances Data)

Usage

General Description

2,3-Diamino-5,6-dichloropyridine is a chemical compound with the molecular formula C5H5Cl2N3. It is a dichloropyridine derivative, which is commonly used as a building block in the synthesis of pharmaceuticals and other organic compounds. 2,3-Diamino-5,6-dichloropyridine is notable for its potential use in the development of antiviral and antimalarial drugs. It is also used in the production of dyes, pigments, and agrochemicals. 2,3-Diamino-5,6-dichloropyridine is a highly reactive and versatile compound that is important in various chemical and pharmaceutical applications due to its unique structural properties.

Upstream product

• 5409-39-2 2-amino-5-chloro-3-nitropyridine 
• 1192814-45-1 5,6-dichloropyridin-2-amine 
• 1192814-44-0 N-(5,6-dichloropyridin-2-yl)pivalamide 
• 86847-84-9 2,2-Dimethyl-N-(6-chloro-2-pyridinyl)propanamide 
• 45644-21-1 6-chloropyridin-2-amine 
• 7647-01-0 hydrogenchloride 
• 27048-04-0 2-amino-6-chloro-3-nitropyridine 
• 203794-33-6 2-amino-5,6-dichloro-3-nitropyridine 

Downstream Products

• 189102-97-4 OH 
• 189102-97-4 5,6-Dichloro-3H-imidazo[4,5-b]pyridine 

Relevant articles and documents

2,3-Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide as selective glycine antagonist with in vivo activity

2,3-Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide was synthesized and evaluated for in vitro/in vivo antagonistic activity at the strychnine insensitive glycine binding site on the NMDA receptor revealing it to be a useful tool to evaluate the effectiveness of glycine antagonists in vivo.

Discovery of a Novel Highly Selective Histamine H4 Receptor Antagonist for the Treatment of Atopic Dermatitis

The histamine H4 receptor (H4R), a member of the G-protein coupled receptor family, has been considered as a potential therapeutic target for treating atopic dermatitis (AD). A large number of H4R antagonists have been disclosed, but no efficient agents controlling both pruritus and inflammation in AD have been developed yet. Here, we have discovered a novel class of orally available H4R antagonists showing strong anti-itching and anti-inflammation activity as well as excellent selectivity against off-targets. A pharmacophore-based virtual screening system constructed in-house successfully identified initial hit compound 9, and the subsequent homology model-guided optimization efficiently led us to discover pyrido[2,3-e]tetrazolo[1,5-a]pyrazine analogue 48 as a novel chemotype of a potent and highly selective H4R antagonist. Importantly, orally administered compound 48 exhibits remarkable efficacy on antipruritus and anti-inflammation with a favorable pharmacokinetic (PK) profile in several mouse models of AD. Thus, these data strongly suggest that our compound 48 is a promising clinical candidate for treatment of AD.

NOVEL HETEROCYCLIC DERIVATIVES AND THEIR USES

The present invention relates to novel heterocyclic compounds useful in preparing drugs for treatment of diseases associated with various functions of the histamine 4 receptor. Especially, the said drugs are useful for treatment of inflammatory diseases, allergy, pain, nasal polyps, rhinitis, chronic sinusitis, nasal congestion, nasal itch, asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, atopic dermatitis, psoriasis, eczema, pruritus, itchy skin, urticaria, idiopathic chronic urticaria, scleroderma, conjunctivitis, keratoconjunctivitis, ocular inflammation, dry eye, cardiac dysfunction, arrhythmia, atherosclerosis, multiple sclerosis, inflammatory bowel disease (including colitis, Crohn's disease, ulcerative colitis), inflammatory pain, neuropathic pain, osteoarthritic pain, autoimmune thyroid disease, immune-mediated (also known as type I) diabetes, lupus, post-operative adhesions, vestibular disorders and cancer.