20386-43-0

Basic information

• Product Name: DIISOPROPYL HYDROXY(PHENYL)METHYLPHOSPHONATE
• Synonyms: DIISOPROPYL HYDROXY(PHENYL)METHYLPHOSPHONATE
• CAS NO: 20386-43-0
• Molecular Formula: C₁₃H₂₁O₄P
• Molecular Weight: 272.28
• Mol File: 20386-43-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: DIISOPROPYL HYDROXY(PHENYL)METHYLPHOSPHONATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIISOPROPYL HYDROXY(PHENYL)METHYLPHOSPHONATE(20386-43-0)
• EPA Substance Registry System: DIISOPROPYL HYDROXY(PHENYL)METHYLPHOSPHONATE(20386-43-0)

Safety Data

• Hazardous Substances Data: 20386-43-0(Hazardous Substances Data)

Usage

Uses

Given the highly toxic nature and classification of DIISOPROPYL HYDROXY(PHENYL)METHYLPHOSPHONATE as a chemical warfare agent, its legitimate uses are extremely limited and strictly regulated. However, for the sake of providing a comprehensive overview, the following applications are mentioned with a strong emphasis on the fact that these are not endorsed or encouraged:
Used in Chemical Warfare:
DIISOPROPYL HYDROXY(PHENYL)METHYLPHOSPHONATE is used as a chemical warfare agent for its ability to act as a potent nerve agent. It is employed for its rapid absorption and severe incapacitating effects on the human nervous system.

Upstream product

• 116-17-6 triisopropyl phosphite 
• 100-52-7 benzaldehyde 
• 1809-20-7 diisopropyl hydrogenphosphonate 
• 100-51-6 benzyl alcohol 
• 691-96-3 diisopropyl phosphite 
• 22950-57-8 diisopropyl benzoylphosphonate 

Downstream Products

• 147731-05-3 diisopropyl (S)-(-)-[hydroxy(phenyl)methyl]phosphonate 
• 131523-50-7 Toluene-4-sulfonic acid (diisopropoxy-phosphoryl)-phenyl-methyl ester 
• 1614827-46-1 O,O-diisopropyl 1-((4,6-dichloropyrimidin-2-yl)carbamyloxy)-1-(phenyl)methylphosphonate 
• 1104635-54-2 diisopropyl α-(p-bromophenylaminothiocarbonyloxy)-α-(phenyl)methyl phosphonate 
• 1104635-61-1 diisopropyl α-(p-ethoxyphenylaminothiocarbonyloxy)-α-(phenyl)methyl phosphonate 
• 104944-23-2 (-)-(S)-1-phenyl-1-hydroxymethylphosphonic acid 
• 596113-52-9 (+/-)-diisopropyl 1-thiocyanatobenzylphosphonate 
• 596113-48-3 (+/-)-diisopropyl 1-(p-nitrobenzenesulfonyloxy)benzylphosphonate 

Relevant articles and documents

Utilization of 1,3-Dioxolanes in the Synthesis of α-branched Alkyl and Aryl 9-[2-(Phosphonomethoxy)Ethyl]Purines and Study of the Influence of α-branched Substitution for Potential Biological Activity

Syntheses of α-branched alkyl and aryl substituted 9-[2-(phosphonomethoxy)ethyl]purines from substituted 1,3-dioxolanes have been developed. Key synthetic precursors, α-substituted dialkyl [(2-hydroxyethoxy)methyl]phosphonates were prepared via Lewis acid mediated cleavage of 1,3-dioxolanes followed by reaction with dialkyl or trialkyl phosphites. The best preparative yields were achieved under conditions utilizing tin tetrachloride as Lewis acid and triisopropyl phosphite. Attachment of purine bases to dialkyl [(2-hydroxyethoxy)methyl]phosphonates was performed by Mitsunobu reaction. Final α-branched 9-[2-(phosphonomethoxy)ethyl]purines were tested for antiviral, cytostatic and antiparasitic activity, the latter one determined as inhibitory activity towards Plasmodium falciparum enzyme hypoxanthine-guanine-xanthine phosphoribosyltransfesase. In most cases biological activity was only marginal.

Cholic acid-alpha-amino phosphonate derivative and synthesis method thereof

The invention belongs to the field of medicine chemistry and particularly relates to a cholic acid-alpha-amino phosphonate derivative and a preparation method thereof.Cholic acid and phosphate ester serve as raw materials, and the cholic acid-alpha-amino

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The invention belongs to the field of pharmaceutical chemistry and particularly relates to novel bile acid-alpha-hydroxyphosphonate compounds and a preparation method thereof. Bile acid and phosphate ester are taken as raw materials, the bile acid-alpha-h

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The invention discloses a rare-earth metal arylamine group compound as well as preparation method and application thereof. The invention discloses the rare-earth metal arylamine group compound which is characterized in that a general formula of the rare-e

N -BuLi as a highly efficient precatalyst for hydrophosphonylation of aldehydes and unactivated ketones

It was found for the first time that organic alkali metal compounds serve as highly efficient precatalysts for the hydrophosphonylation reactions of aldehydes and unactivated ketones with dialkyl phosphite under mild conditions. For ketone substrates, a reversible reaction was observed, and the influence of catalyst loading and reaction temperature on the reaction equilibrium was studied in detail. Overall, the hydrophosphonylation reactions catalyzed by 0.1 mol % n-BuLi were completed within 5 min for a broad range of substrates and generated a series of α-hydroxy phosphonates in high yields.

Synthesis and biological activities of O, O-dialkyl 1-((4,6- Dichloropyrimidin-2-yl)carbamyloxy) alkylphosphonates

(Equation present) A series of new 1-((4,6-dichloropyrimidin-2-yl) carbamyloxy) alkylphosphonates were designed and synthesized. The structures of all the title compounds were confirmed by IR, 1H-NMR, 31P-NMR and elemental analysis. The results of the bioassay showed that all of title compounds exhibited weak herbicidal activities against monocotyledons and dicotyledons; however, some of them showed potential plant growth regulatory activities. 2014 Copyright Taylor & Francis Group, LLC.

Copper-catalyzed synthesis of α-hydroxy phosphonates from H-phosphonates and alcohols or ethers

Easy PC: α-Hydroxy phosphonates were synthesized by copper/tert-butyl hydroperoxide (TBHP)-catalyzed oxidative addition reactions of H-phosphonates with alcohols or ethers. Diverse α-hydroxy phosphonates were obtained from substituted benzyl alcohols or alkyl alcohols and alkyl ethers in moderate to good yields. Copyright

Mechanistic approach for expeditious and solvent-free synthesis of α-hydroxy phosphonates using potassium phosphate as catalyst

An extremely simple, high yielding, highly rapid and solvent-free protocol has been described for hydrophosphylation of aldehydes using potassium phosphate as catalyst. Easy commercial availability of the reusable catalyst, operational simplicity at ambie

Lanthanide amides [(Me3Si)2N]3Ln(μ-Cl) Li(THF)3 catalyzed hydrophosphonylation of aryl aldehydes

A highly efficient method for the synthesis of α-hydroxy phosphonates via lanthanide amides [(Me3Si)2N]3Ln(μ-Cl) Li(THF)3 catalyzed hydrophosphonylation of aromatic aldehydes was developed. The reactions produce

Synthesis, characterizations, and crystal structures of α-hydroxyphosphonic acid esters

This article describes the synthesis of -hydroxyphosphonic acid esters using the Pudovik reaction. IR, 1H NMR, 13C NMR, 31P NMR, MS, and elemental analysis were employed to confirm their structures. X-ray structure analysi