203922-18-3Relevant articles and documents
Rational design of novel CYP2A6 inhibitors
Tani, Niina,Juvonen, Risto O.,Raunio, Hannu,Fashe, Muluneh,Lepp?nen, Jukka,Zhao, Bin,Tyndale, Rachel F.,Rahnasto-Rilla, Minna
, p. 6655 - 6664 (2014)
Inhibition of CYP2A6-mediated nicotine metabolism can reduce cigarette smoking. We sought potent and selective CYP2A6 inhibitors to be used as leads for drugs useful in smoking reduction therapy, by evaluating CYP2A6 inhibitory effect of novel formyl, alk
Orally bioavailable highly potent HIV protease inhibitors against PI-resistant virus
Lu, Zhijian,Bohn, Joann,Rano, Tom,Rutkowski, Carrie A.,Simcoe, Amy L.,Olsen, David B.,Schleif, William A.,Carella, Anthony,Gabryelski, Lori,Jin, Lixia,Lin, Jiunn H.,Emini, Emilio,Chapman, Kevin,Tata, James R.
, p. 5311 - 5314 (2007/10/03)
Efforts directed to identifying potent HIV protease inhibitors (PI) have yielded a class of compounds that are not only very active against wild-type (NL4-3) HIV virus but also very potent against a panel of PI-resistant viral isolates. Chemistry and biol
Nonlinear optical chromophores with isoquinolines, thieno[2,3-c]-pyridines and 2-(2′-thienyl)pyridines as inherently polarized π-electron bridges
Nerenz, Heiko,Meier, Martin,Grahn, Walter,Reisner, Axel,Schmaelzlin, Elmar,Stadler, Stefan,Meerholz, Klaus,Braeuchle, Christoph,Jones, Peter G.
, p. 437 - 447 (2007/10/03)
The synthesis and first hyperpolarizabilities of a series of isoquinolines and isoquinolinium salts, and also thienopyridines, thienylpyridines, and the corresponding pyridinium salts, determined by hyper-Rayleigh scattering in solution at 1064 and 1300 nm, are reported. These chromophores exhibit markedly high β values. Some of them show absorption maxima well below 400 nm, enabling their use in blue transparent frequency doubling devices. We have performed X-ray structure analyses for thienopyridines 13a,c.
