Thieno[2,3-C]pyridine-2-carbaldehyde

Base Information

• Chemical Name: Thieno[2,3-C]pyridine-2-carbaldehyde
• CAS No.: 203922-18-3
• Molecular Formula: C₈H₅NOS
• Molecular Weight: 163.2
• Hs Code.: 2934999090
• European Community (EC) Number: 823-524-9
• DSSTox Substance ID: DTXSID70444275
• Wikidata: Q82262374
• Pharos Ligand ID: S9137RK3RJ6S
• ChEMBL ID: CHEMBL3358193
• Mol file: 203922-18-3.mol

Synonyms:THIENO[2,3-C]PYRIDINE-2-CARBALDEHYDE;203922-18-3;CHEMBL3358193;SCHEMBL1335259;DTXSID70444275;BDBM50037776;MFCD11052828;AKOS006308663;CS-0215782;D79728;EN300-300158;THIENO[2,3-C]PYRIDINE-2-CARBALDEHYDE 96%;Z1198309374

Chemical Property of Thieno[2,3-C]pyridine-2-carbaldehyde

Chemical Property:

• PSA: 58.20000
• LogP: 2.10880
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 163.00918496
• Heavy Atom Count: 11
• Complexity: 162

Purity/Quality:

97% ^*data from raw suppliers

thieno[2,3-c]pyridine-2-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=CC2=C1C=C(S2)C=O

Technology Process of Thieno[2,3-C]pyridine-2-carbaldehyde

There total 3 articles about Thieno[2,3-C]pyridine-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

thieno[2,3-c]-pyridine (272-12-8) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → thieno[2,3-c]pyridine-2-carbaldehyde (203922-18-3)

Guidance literature:

thieno[2,3-c]-pyridine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -78 ℃;

DOI:10.1016/j.bmc.2014.10.001

Reference yield:

thieno[2,3-c]-pyridine (272-12-8) + formic acid ethyl ester (109-94-4) → thieno[2,3-c]pyridine-2-carbaldehyde (203922-18-3)

Guidance literature:

thieno[2,3-c]-pyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

formic acid ethyl ester; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2005.08.072

Reference yield:

N-Formylpiperidine (2591-86-8) + thieno[2,3-c]-pyridine (272-12-8) → thieno[2,3-c]pyridine-2-carbaldehyde (203922-18-3)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1) THF, hexane, 0 deg C, 15 min; 2) THF, hexane, 20-25 deg C, 2.5 h;

upstream raw materials:

N-Formylpiperidine

thieno[2,3-c]-pyridine

formic acid ethyl ester

N,N-dimethyl-formamide