272-12-8

Usage

Uses

Used in Pharmaceutical Industry:
Thieno[2,3-c]pyridine is used as a building block for the synthesis of organic compounds and pharmaceuticals, particularly for the development of drug candidates with potential biological activities. Its derivatives have been studied for their anti-cancer properties, making it a valuable component in the creation of novel therapeutic agents.
Used in Anti-inflammatory Applications:
Thieno[2,3-c]pyridine is used as an anti-inflammatory agent, leveraging its potential to modulate biological pathways associated with inflammation, thereby offering a new avenue for the treatment of inflammatory conditions.
Used in Protein Kinase Inhibition:
As an inhibitor of protein kinases, Thieno[2,3-c]pyridine is utilized in the development of compounds that can regulate cellular processes by inhibiting specific protein kinases, which are often implicated in various diseases, including cancer.
Used in Organic Electronics:
Thieno[2,3-c]pyridine compounds are explored for their potential use in organic electronics, taking advantage of their electronic properties to improve the performance of electronic devices and materials.
Used in Optoelectronic Devices:
In the optoelectronics field, Thieno[2,3-c]pyridine is used for its potential application in the development of materials for optoelectronic devices, such as solar cells and light-emitting diodes, due to its favorable optical and electronic characteristics.

InChI:InChI=1/C7H5NS/c1-3-8-5-7-6(1)2-4-9-7/h1-5H

Upstream product

• 60249-08-3 thieno[2,3-c]pyridine-5-carboxylic acid 
• 74301-92-1 C₁₀H₁₀N₂O₂S 
• 110-86-1 pyridine 
• 102000-77-1 4-ethyl-pyridine-3-thiol 
• 98-03-3 thiophene-2-carbaldehyde 
• 60249-06-1 thieno[2,3-c]pyridine-5-carboxylic acid ethyl ester 
• 79180-12-4 2,4,6-Trimethyl-benzenesulfonate6-amino-thieno[2,3-c]pyridin-6-ium; 
• 58754-99-7 dimethoxy-N-(thiophen-2-ylmethyl)ethanamine 
• 756477-25-5 {[(2,2-Dimethoxy-ethyl)-ethoxycarbonyl-amino]-thiophen-2-yl-methyl}-phosphonic acid dimethyl ester 
• 113825-04-0 (2,2-diethoxy-ethyl)-thiophen-2-ylmethylene-amine 
• 7664-93-9 sulfuric acid 
• 10025-87-3 trichlorophosphate 
• 86119-84-8 phosphoric acid 
• 58754-98-6 N-(2,2-dimethoxyethyl)-4-methyl-N-(thiophen-2-ylmethyl)benzenesulfonamide 

Downstream Products

• 28783-28-0 3-Nitrothieno<2,3-c>pyridin 
• 110071-79-9 1,3-Diphenyl-1,9b-dihydro-thieno[2,3-c][1,2,4]triazolo[4,3-a]pyridine 
• 110071-82-4 1-(4-Nitro-phenyl)-3-phenyl-1,9b-dihydro-thieno[2,3-c][1,2,4]triazolo[4,3-a]pyridine 
• 79180-12-4 2,4,6-Trimethyl-benzenesulfonate6-amino-thieno[2,3-c]pyridin-6-ium; 
• 110071-80-2 3-(4-Methoxy-phenyl)-1-phenyl-1,9b-dihydro-thieno[2,3-c][1,2,4]triazolo[4,3-a]pyridine 
• 93582-95-7 6-Benzoyl-7-cyano-6,7-dihydrothieno<2,3-c>pyridine 
• 203922-18-3 thieno[2,3-c]pyridine-2-carbaldehyde 
• 875415-18-2 1,1,1-Trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-thieno[2,3-c]pyridin-2-ylmethylpentan-2-ol 
• 1402598-51-9 N-((2-methoxyphenyl)(thieno[2,3-c]pyridin-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide 
• 1402598-46-2 N-((2-(methylsulfanyl)phenyl)(thieno[2,3-c]pyridin-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide 
• 1402598-42-8 N-(phenyl(thieno[2,3-c]pyridin-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide 
• 63326-75-0 thieno[2,3-c]pyridin-3-amine 
• 93612-34-1 3-Phenylpyrrolo<6,7-a>thieno<2,3-c>pyridine-2-carboxamide 
• 93582-98-0 6-Benzoyl-7-methyl-6,7-dihydro-thieno[2,3-c]pyridine-7-carbonitrile 

Relevant academic research and scientific papers

Thieno[2,3-c]pyridine, the first structure of a thienopyridine

The title molecule, C7H5NS, is planar to within 0.009 A. Bond lengths at the heteroatoms are S1-C2 1.7276 (14), S1-C7a 1.7308 (13), N6-C5 1.354 and N6-C7 1.332 (2) A; the C-S-C angle is 90.76 (6)°. A libration analysis indicated corrections of 0.003-0.004 A. Short intermolecular contacts [S1...N6 3.229 (1) A] link the molecules into chains parallel to the y axis.

Therapeutic Pyrazolyl Thienopyridines

The present invention provides for compounds of Formula I, and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, and R7 have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as therapeutic agents in the treatment of TGFβ-mediated conditions, including cancer and fibrotic disorders. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.

Synthesis and radioligand binding studies of C-5- and C-8-substituted 1-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinoliniums as SK channel blockers related to N-methyl-laudanosine and N-methyl-noscapine

The synthesis and the 125I-apamin binding studies of original C-5- and C-8-substituted 1-(3,4-dimethoxy-benzyl)-2,2-dimethyl-1,2,3,4- tetrahydroisoquinoliniums and 1-(3,4-dimethoxy-benzyl)-6,6-dimethyl-4,5,6,7- tetrahydrothieno[2,3-c]pyridiniums were performed in order to find a reversible and selective SK channel blocker structurally related to N-methyl-laudanosine and N-methyl-noscapine. A bulky alkyl substituent in the C-8 position of the tetrahydroisoquinoline produces a clear increase in the affinity for the apamin sensitive binding sites. The presence of an electron-withdrawing group in the C-5 and C-8 positions is not a suitable substitution for the affinity of drugs structurally related to N-methyl-laudanosine. Thiophenic analogues and 8-methoxy derivatives possess a poor affinity for the apamin sensitive binding sites. Electrophysiological studies performed with the most effective compound showed a blockade of the apamin sensitive afterhyperpolarization in rat dopaminergic neurons.

A rapid synthesis of thieno[2,3-c]pyridine and 2-substituted thieno[2,3-c]pyridines

A convenient preparation of thieno[2,3-c]pyridine 3a and of several original 2-substituted-thieno[2,3-c]pyridines 3b-f is achieved by cyclization of the Schiff base resulting from the condensation between a 2- thiophenecarboxaldehyde 1a-f and aminoacetaldehyde dimethyl acetal. This procedure provides especially good yields in the case of 2-halogenated analogues.

FUNGAL CELL WALL SYNTHESIS GENE

A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these genes were developed.Therefore, through the novel compounds, the present invention showed that antifungal agents having a novel mechanism, i.e. inhibiting the process that transports GPI-anchored proteins to the cell wall, could be achieved.

Process for the preparation of thieno [3,2-c] pyridine and thieno [2,3-c] py

The present invention relates to a process for the preparation of thieno[3,2-c]pyridine or thieno[2,3-c]pyridine, comprising cyclizing a N-(3-thienyl)-methyl-N-[ 2,2-(OR)2 ]ethyl-para-toluene sulfonamide or a N-(2-thienyl)-methyl-N-[2,2-(OR)2 ]ethyl-para-toluene sulfonamide, respectively, in which R is lower alkyl or both R groups form together a 2- or 3-membered alkylene radical, by treatment with an acid in the presence of an inert organic solvent.