205382-87-2Relevant articles and documents
Application of the DP4 Probability Method to Flexible Cyclic Peptides with Multiple Independent Stereocenters: The True Structure of Cyclocinamide A
Cooper, Jason K.,Li, Kelin,Aubé, Jeffrey,Coppage, David A.,Konopelski, Joseph P.
supporting information, p. 4314 - 4317 (2018/07/29)
A DP4 protocol has been successfully utilized to establish the true structure of the natural product cyclocinamide A, a flexible cyclic peptide with four isolated stereocenters. Benchmarking the necessary level of theory required to successfully predict t
POSITIVE ALLOSTERIC MODULATORS OF MUSCARINIC M2 RECEPTOR
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Paragraph 1049-1051, (2018/11/21)
The present application relates to positive allosteric modulators of the muscarinic M2 receptor, especially to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of cardiovascular disorders and/or renal disorders.
Synthesis of homochiral tetrahydropteridines
Baker, Stephen J.,Beresford, Kenneth J.M.,Young, Douglas W.
, p. 7221 - 7228 (2017/09/13)
A synthesis of protected homochiral tetrahydropteridines from (2S)-malic acid has been developed. This presents methodology for the synthesis of reduced pteridine coenzymes and pharmaceuticals.
Efficient synthesis of N-benzyloxycarbonyl- and N-tert-butoxycarbonyl-(S)-isoserine and their derivatives
Andruszkiewicz, Ryszard,Wyszogrodzka, Monika
, p. 2101 - 2103 (2007/10/03)
A mild and efficient synthesis of N-protected (S)-isoserine from (S)-malic acid monoester via an oxazolidin-2-one is described.
Influence of lewis acids on the regioselectivity of N-Boc-aziridine-2-carboxylate microwave-assisted rearrangement
Cardillo,Gentilucci,Gianotti,Tolomelli
, p. 1309 - 1311 (2007/10/03)
The microwave assisted rearrangement of N-Boc-chiral aziridine-2-imides and esters to oxazolidin-2-ones in the presence of different Lewis acids is presented. The regioselectivity of the reaction strongly depends upon the Lewis acid selected and the react
REACTIVITY OF N,N-DICHLOROURETHANES. IX. ADDITION OF N,N-DICHLOROURETHANES TO ALKENES WITH ELECTRON-WITHDRAWING GROUPS
Bal'on, Ya. G.,Paranyuk, V. E.
, p. 481 - 486 (2007/10/02)
The addition of N,N-dichlorourethanes to derivatives of acrylic acid in the presence of catalytic amounts of copper powder or cuprous chloride gave the adducts RCHClCH2N(Cl)COOAlk, where R = CN, COOCH3, and CONH2.When treated with an aqueous solution of s