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3-CHLORO-3-(4-FLUOROPHENYL)ACRYLONITRILE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 205984-77-6 Structure
  • Basic information

    1. Product Name: 3-CHLORO-3-(4-FLUOROPHENYL)ACRYLONITRILE
    2. Synonyms: BUTTPARK 91\18-16;3-CHLORO-3-(4-FLUOROPHENYL)ACRYLONITRILE;(Z)-3-Chloro-3-(4-fluorophenyl)acrylonitrile
    3. CAS NO:205984-77-6
    4. Molecular Formula: C9H5ClFN
    5. Molecular Weight: 181.59
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 205984-77-6.mol
  • Chemical Properties

    1. Melting Point: 90 °C
    2. Boiling Point: 275.1°C at 760 mmHg
    3. Flash Point: 120.2°C
    4. Appearance: /
    5. Density: 1.272g/cm3
    6. Vapor Pressure: 0.00518mmHg at 25°C
    7. Refractive Index: 1.55
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 3-CHLORO-3-(4-FLUOROPHENYL)ACRYLONITRILE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 3-CHLORO-3-(4-FLUOROPHENYL)ACRYLONITRILE(205984-77-6)
    12. EPA Substance Registry System: 3-CHLORO-3-(4-FLUOROPHENYL)ACRYLONITRILE(205984-77-6)
  • Safety Data

    1. Hazard Codes: Xn
    2. Statements: 22
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 205984-77-6(Hazardous Substances Data)

205984-77-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 205984-77-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,5,9,8 and 4 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 205984-77:
(8*2)+(7*0)+(6*5)+(5*9)+(4*8)+(3*4)+(2*7)+(1*7)=156
156 % 10 = 6
So 205984-77-6 is a valid CAS Registry Number.
InChI:InChI=1/C9H5ClFN/c10-9(5-6-12)7-1-3-8(11)4-2-7/h1-5H/b9-5+

205984-77-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-chloro-3-(4-fluorophenyl)acrylonitrile

1.2 Other means of identification

Product number -
Other names 3-chloro-3-(4'-fluorophenyl)-2-propene-nitrile

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:205984-77-6 SDS

205984-77-6Relevant articles and documents

Novel benzenesulfonamide-bearing pyrazoles and 1,2,4-thiadiazoles as selective carbonic anhydrase inhibitors

Kumar, Rajiv,Kumar, Amit,Ram, Sita,Angeli, Andrea,Bonardi, Alessandro,Nocentini, Alessio,Gratteri, Paola,Supuran, Claudiu T.,Sharma, Pawan K.

, (2021/10/05)

Two series comprising 20 novel benzenesulfonamides bearing thioureido-linked pyrazole 8 and amino-1,2,4-thiadiazole 10 were synthesized and assayed as human carbonic anhydrase (hCA) inhibitors against isoforms I and II as well as the tumor-associated isof

Deadly KCN and pricey metal free track for accessing β-ketonitriles employing mild reaction conditions

Sharma, Pawan K.,Kumar, Rajiv,Ram, Sita,Chandak, Navneet

supporting information, p. 1847 - 1856 (2021/04/26)

A one pot synthesis of β-ketonitriles from readily accessible 3-chloropropenals using economically benign iodine, aqueous ammonia and sodium hydroxide solution, employing mild reaction conditions have been described. This report presents a convenient, inexpensive, highly toxic-matter-free and eco-friendly approach for β-ketonitriles.

Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2- d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors

Romagnoli, Romeo,Prencipe, Filippo,Oliva, Paola,Baraldi, Stefania,Baraldi, Pier Giovanni,Schiaffino Ortega, Santiago,Chayah, Mariem,Kimatrai Salvador, Maria,Lopez-Cara, Luisa Carlota,Brancale, Andrea,Ferla, Salvatore,Hamel, Ernest,Ronca, Roberto,Bortolozzi, Roberta,Mariotto, Elena,Mattiuzzo, Elena,Viola, Giampietro

supporting information, p. 1274 - 1290 (2019/01/30)

The clinical evidence for the success of tyrosine kinase inhibitors in combination with microtubule-targeting agents prompted us to design and develop single agents that possess both epidermal growth factor receptor (EGFR) kinase and tubulin polymerization inhibitory properties. A series of 6-aryl/heteroaryl-4-(3′,4′,5′-trimethoxyanilino)thieno[3,2-d]pyrimidine derivatives were discovered as novel dual tubulin polymerization and EGFR kinase inhibitors. The 4-(3′,4′,5′-trimethoxyanilino)-6-(p-tolyl)thieno[3,2-d]pyrimidine derivative 6g was the most potent compound of the series as an antiproliferative agent, with half-maximal inhibitory concentration (IC50) values in the single- or double-digit nanomolar range. Compound 6g bound to tubulin in the colchicine site and inhibited tubulin assembly with an IC50 value of 0.71 μM, and 6g inhibited EGFR activity with an IC50 value of 30 nM. Our data suggested that the excellent in vitro and in vivo profile of 6g may be derived from its dual inhibition of tubulin polymerization and EGFR kinase.

One-pot synthesis of 2-substituted thieno[3,2-b]indoles from 3-aminothiophene-2-carboxylates through in situ generated 3-aminothiophenes

Irgashev, Roman A.,Steparuk, Alexander S.,Rusinov, Gennady L.

supporting information, (2019/09/30)

A convenient protocol for one-pot synthesis of thieno[3,2-b]indoles, bearing aromatic, thien-2-yl or styryl fragments at C-2 position, from easily accessible 5-substituted 3-aminothiophene-2-carboxylates using the Fischer indolization reaction, was develo

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