126417-81-0

Basic information

• Product Name: 3-(4-Fluorophenyl)-1-methyl-1H-pyrazol-5-amine
• Synonyms: ASINEX-REAG BAS 07754283;BUTTPARK 34\07-82;5-(4-FLUORO-PHENYL)-2-METHYL-2H-PYRAZOL-3-YLAMINE;3-(4-Fluorophenyl)-1-methyl-1H-pyrazol-5-amine;3-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-amine(SALTDATA: FREE);1H-Pyrazol-5-amine, 3-(4-fluorophenyl)-1-methyl-;3-(4-fluorophenyl)-1-methyl-1H-pyrazole-5-amine
• CAS NO: 126417-81-0
• Molecular Formula: C₁₀H₁₀FN₃
• Molecular Weight: 191.2
• Mol File: 126417-81-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 364.2 °C at 760 mmHg
• Flash Point: 174.1 °C
• Appearance: /
• Density: 1.26 g/cm³
• Vapor Pressure: 1.71E-05mmHg at 25°C
• Refractive Index: 1.607
• CAS DataBase Reference: 3-(4-Fluorophenyl)-1-methyl-1H-pyrazol-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Fluorophenyl)-1-methyl-1H-pyrazol-5-amine(126417-81-0)
• EPA Substance Registry System: 3-(4-Fluorophenyl)-1-methyl-1H-pyrazol-5-amine(126417-81-0)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45
• HazardClass: IRRITANT
• Hazardous Substances Data: 126417-81-0(Hazardous Substances Data)

Usage

General Description

3-(4-Fluorophenyl)-1-methyl-1H-pyrazol-5-amine is a chemical compound with the molecular formula C10H10FN3. It is a member of the pyrazole class of chemicals and contains a fluorophenyl group and a methyl group. 3-(4-Fluorophenyl)-1-methyl-1H-pyrazol-5-amine has potential applications as a pharmaceutical intermediate and may be of interest in drug discovery and development. It is important to handle and use this chemical with care, following all proper safety protocols and regulations, as it may pose health and environmental hazards if not handled properly.

InChI:InChI=1/C10H10FN3/c1-14-10(12)6-9(13-14)7-2-4-8(11)5-3-7/h2-6H,12H2,1H3

Upstream product

• 943863-70-5 3-(4-fluorophenyl)-1-methyl-1H-pyrazole-5-carboxylic acid 
• 943863-69-2 1-methyl-3-(4-fluorophenyl)-1H-pyrazole-5-carboxylic acid ethyl ester 
• 866588-11-6 3-(4-chlorophenyl)-1H-pyrazole-5-carboxylic acid ethyl ester 
• 1224879-05-3 (Z)-ethyl 4-(4-fluorophenyl)-2-hydroxy-4-oxobut-2-enoate 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 205984-77-6 3-chloro-3-(4-fluorophenyl)acrylonitrile 
• 60-34-4 methylhydrazine 

Downstream Products

• 126418-03-9 N-[5-(4-Fluoro-phenyl)-2-methyl-2H-pyrazol-3-yl]-4-methyl-benzenesulfonamide 

Relevant articles and documents

Diaryl pyrazole compound and its preparation method and application

The invention discloses a diarylpyrazole compound as well as a preparation method and application of the diarylpyrazole compound. The structure is shown as a general formula (I) shown as the accompanying drawing, wherein R1 is hydrogen, halogen or methyl; R2 is hydrogen, cyanogroup, trifluoromethyl or halogen; R3 is hydrogen, halogen or nitrile groups; X shown as the formula is carbamoyl, thioureido, methylamino or aminomethyl. The diarylpyrazole compound, particularly 11aM01, 11aM02, 11M04, 13aM01, 16aM01, 16aM02, 16aM10, 16aM11, 16aM12 and 16aM15 have higher cell growth inhibition activity on prostate cancer cells LNCaP and PC-3, 11aM03, 12aM01, 12aM02, 16aM05, 16aM06, 16aM07, 16aM08, 16aM13 and 16aM16 have higher selectivity on prostate cancer cells LNCaP, and all compounds can be used for preparing antineoplastic medicine.

Azoles. Part 25: Isomeric 3- and 5-aminopyrazole derivatives

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