206067-84-7

Basic information

• Product Name: 6H-PURIN-6-ONE, 1,9-DIHYDRO-9-[3-[[(4-METHOXYPHENYL)DIPHENYLMETHOXY]METHYL]-4-[[(4-METHYLPHENYL)SULFONYL]OXY]BUTYL]-2-[[(4-METHOXYPHENYL)DIPHENYLMETHYL]AMINO]-
• Synonyms: TOSYL-FHBG;N2-(P-ANISYLDIPHENYLMETHYL)-9-[(4-(P-TOLUOLSULFONYLOXY))-3-P-ANISYLDIPHENYLMETHOXY-METHYLBUTYL]GUANINE;6H-PURIN-6-ONE, 1,9-DIHYDRO-9-[3-[[(4-METHOXYPHENYL)DIPHENYLMETHOXY]METHYL]-4-[[(4-METHYLPHENYL)SULFONYL]OXY]BUTYL]-2-[[(4-METHOXYPHENYL)DIPHENYLMETHYL]AMINO]-;6H-Purin-6-one, 1,9-dihydro-9-;N2-(p-Anisyldiphenylmethyl)-9-[(4-(p-toluolsulfonyloxy))-3-p-anisyldiphenylmethoxy-methylbutyl]guanin;6H-Purin-6-one, 1,9-dihydro-9- [3-[[(4-methoxyphenyl)diphenylmethoxy]methyl]- 4-[[(4-methylphenyl)sulfonyl]oxy]butyl]- 2-[[(4-methoxyphenyl)diphenylmethyl]amino]-
• CAS NO: 206067-84-7
• Molecular Formula: C₅₇H₅₃N₅O₇S
• Molecular Weight: 952.13
• Mol File: 206067-84-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6H-PURIN-6-ONE, 1,9-DIHYDRO-9-[3-[[(4-METHOXYPHENYL)DIPHENYLMETHOXY]METHYL]-4-[[(4-METHYLPHENYL)SULFONYL]OXY]BUTYL]-2-[[(4-METHOXYPHENYL)DIPHENYLMETHYL]AMINO]-(CAS DataBase Reference)
• NIST Chemistry Reference: 6H-PURIN-6-ONE, 1,9-DIHYDRO-9-[3-[[(4-METHOXYPHENYL)DIPHENYLMETHOXY]METHYL]-4-[[(4-METHYLPHENYL)SULFONYL]OXY]BUTYL]-2-[[(4-METHOXYPHENYL)DIPHENYLMETHYL]AMINO]-(206067-84-7)
• EPA Substance Registry System: 6H-PURIN-6-ONE, 1,9-DIHYDRO-9-[3-[[(4-METHOXYPHENYL)DIPHENYLMETHOXY]METHYL]-4-[[(4-METHYLPHENYL)SULFONYL]OXY]BUTYL]-2-[[(4-METHOXYPHENYL)DIPHENYLMETHYL]AMINO]-(206067-84-7)

Safety Data

• Hazardous Substances Data: 206067-84-7(Hazardous Substances Data)

Usage

Chemical Properties

Off-white solid

Upstream product

• 97845-77-7 9-(4-hydroxy-3-{[(4-methoxyphenyl)diphenylmethoxy]methyl}butyl)-2-{[(4-methoxyphenyl)diphenylmethyl]amino}-6,9-dihydro-1H-purin-6-one 
• 98-59-9 p-toluenesulfonyl chloride 
• 39809-25-1 Penciclovir 
• 14470-28-1 mono-4-methoxytrityl chloride 
• 7459-46-3 triethyl 1,1,2-ethanetricarboxylate 
• 6482-32-2 2-(hydroxymethyl)butane-1,4-diol 
• 97845-58-4 5-(2-bromoethyl)-2,2-dimethyl-1,3-dioxane 
• 102147-75-1 2,2-dimethyl-5-(2'-hydroxyethyl)-1,3-dioxane 
• 97845-59-5 2-amino-6-chloro-9-<2-(2,2-dimethyl-1,3-dioxan-5-yl)ethyl>purine 

Downstream Products

• 206067-85-8 N²-(p-anisyldiphenylmethyl)-9-[(4-fluoro)-3-p-anisyldiphenylmethoxy-methylbutyl]guanine 
• 718633-33-1 N¹-methyl-N²-(p-anisyldiphenylmethyl)-9-[(4-fluoro)-3-p-anisyldiphenylmethoxy-methyl-butyl]guanine 
• 693260-23-0 9-{3-azidomethyl-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-butyl}-2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-1,9-dihydro-purin-6-one 
• 718633-31-9 N¹-methyl-N²-(p-anisyldiphenylmethyl)-9-[(4-(p-toluenesulfonyloxy))-3-p-anisyldiphenylmethoxy-methylbutyl]guanine 

Relevant articles and documents

Efficient synthesis of 9-(4-[18F]fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG) and 9-[(3-[18F]fluoro-1-hydroxy-2-propoxy)methyl]guanine ([18F]FHPG)

A new, high radiochemical yield synthesis of [18F]FHBG and [18F]FHPG, the most popular imaging agents currently in use for monitoring gene therapy using positron emission tomography (PET), is reported in this work. Protection of sens

The new convenient synthesis of fluorinated Penciclovir analogues 9-(4-fluoro-3-hydroxymethylbutyl) guanine (FHBG) and 2-amino-6-fluoro-9-(4-hydroxy-3-hydroxymethylbutyl) purine (6-Fluoropenciclovir)

9-(4-Hydroxy-3-hydroxymethylbutyl) guanine (Penciclovir) is a potent and selective inhibitor of members of the herpes virus family. A new convenient synthesis of fluorinated Penciclovir analogues 9-(4-fluoro-3-hydroxymethylbutyl) guanine (FHBG) and 2-amin

N2S2 chelate-targeting ligand conjugates

The invention provides, in a general sense, a new labeling strategy employing compounds that are are N2S2 chelates conjugated to a targeting ligand, wherein the targeting ligand is a disease cell cycle targeting compound, a tumor ang

Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging

The invention provides, in a general sense, a new labeling strategy employing compounds that are are N2S2 chelates conjugated to a targeting ligand, wherein the targeting ligand is a disease cell cycle targeting compound, a tumor ang

An Improved Total Synthesis of PET HSV-tk Gene Reporter Probe 9-(4-[ 18F]Fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG)

An improved total synthesis of [18F]FHBG starting from triethyl-1,1,2-ethanetricarboxylate and 2-amino-6-chloropurine is reported. [18F]FHBG was prepared by nucleophilic substitution of the appropriate precursor with [18F]KF/Kryptofix 2.2.2 followed by a quick deprotection reaction and purification with a simplified Silica Sep-Pak solid-phase extraction (SPE) method in 20-25% radiochemical yield.

Novel radiosynthesis of PET HSV-tk gene reporter probes [ 18F]FHPG and [18F]FHBG employing dual Sep-Pak SPE techniques

Positron emission tomography (PET) herpes simplex virus thymidine kinase (HSV-tk) gene reporter probes 9-[(3-[18F]fluoro-1-hydroxy-2-propoxy) methyl]guanine ([18F]FHPG) and 9-(4-[18F]fluoro-3- hydroxymethylbutyl)guanine ([18F]FHBG) were prepared by nucleophilic substitution of the appropriate tosylated precursors with [18F]KF/ Kryptofix 2.2.2 followed by a quick deprotection reaction and purification with a simplified dual Silica Sep-Pak solid-phase extraction (SPE) method in 15-30% radiochemical yield.