20619-13-0

Usage

InChI:InChI=1/C14H15ClN2/c15-12-6-4-11(5-7-12)13(8-9-16)14-3-1-2-10-17-14/h1-7,10,13H,8-9,16H2

Upstream product

• 122376-81-2 2-(4-Chloro-phenyl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-pyridin-2-yl-butyronitrile 
• 5005-37-8 2-(4-chlorophenyl)-2-(pyridin-2-yl)acetonitrile 
• 140-53-4 p-chlorobenzyl cyanide 
• 4350-41-8 2-(4-chlorobenzyl)pyridine 
• 59067-07-1 3-bromopropinaldehyde diethyl acetal 
• 58498-12-7 4-(2-Pyridinylmethyl)phenylamine 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 109-04-6 2-bromo-pyridine 
• 160911-84-2 1-(4-chlorophenyl-1-(2-pyridyl))ehylene 
• 109-09-1 2-chloropyridine 
• 405551-69-1 3-(4-chloro-phenyl)-3-pyridin-2-yl-acrylonitrile 
• 6318-51-0 2-(4-chlorobenzoyl)pyridine 
• 405551-70-4 3-(4-chlorophenyl)-3-(pyridin-2-yl)propanenitrile 

Downstream Products

• 405551-74-8 2-[1-(4-chloro-phenyl)-3-isocyanato-propyl]-pyridine 
• 405551-80-6 N-[3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-3-(1-trityl-1H-imidazol-4-yl)-propionamide 
• 405551-76-0 N-[3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-4-(1-trityl-1H-imidazol-4-yl)-butyramidine 
• 113-92-8 chlorphenamine maleate 
• 405551-87-3 1-[3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-3-[4-(1-trityl-1H-imidazol-4-yl)-butyl]-urea 
• 405551-81-7 N-[3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-N-methyl-3-(1-trityl-1H-imidazol-4-yl)-propionamide 
• 725738-26-1 [3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-amine 
• 725738-46-5 [3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-methyl-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-amine 

Relevant academic research and scientific papers

1/10-water maleic acid chlorpheniramine compound and pharmaceutical composition thereof (by machine translation)

The invention discloses-water 1/10 maleic acid chlorphenamine maleate compound and a preparation method thereof, wherein the compound is measured by a powder X-2 θ ± 0.2° ray diffraction method and shows characteristic 12.4 ° diffraction peaks 18.9 ° 13.1 ° at 20.3 ° 19.4 ° diffraction 21.6 ° 22.0 ° angles in 24.2 ° 24.7 °, 25.1 ° 26.3 ° and 30.1 ° 32.3 °. 1/10 Water prepared by the method has the advantages of good stability, high purity, good solubility and high bioavailability of the preparation, and is simple in process, high in yield, high in repeatability and suitable for industrial production. (by machine translation)

Rhodium-Catalyzed Cyanation of C(sp2)-H Bond of Alkenes

Efficient and selective rhodium-catalyzed cyanation of chelation-assisted C-H bonds of alkenes has been accomplished using environmentally benign N-cyano-N-phenyl-p-methylbenzenesulfonamide (NCTS) as a cyanating reagent. The developed methodology tolerates various functional groups and allows the synthesis of diverse substituted acrylonitriles in good to excellent yields. Furthermore, the potential of the methodology was demonstrated through the formal synthesis of chlorpheniramine-based antagonist.

Identification of a dual histamine H1/H3 receptor ligand based on the H1 antagonist chlorpheniramine

Combining the first generation H1 antihistamine chlorpheniramine (1) with H3 ligands of the alkylamine type has led to the identification of compound 9d, a dual ligand of both the H1 and H3 receptors.

Synthesis of Primary ω-Phenyl-ω-pyridylalkylamines

Phthalimidoalkylation of phenylpyridylacetonitriles followed by acidic or basic hydrolysis and decarboxylation is a convenient method for the preparation of pheniramine-like primary amines.Substituted dihydropyrrolamines were isolated as intermediates in the synthesis of the corresponding propylamines.Alternatively, 3,3-diarylpropylamines were prepared via Horner-Emmons reaction of pertinent ketones with diethyl cyanomethanephosphonate followed by reduction with complex hydrides.