206278-28-6

Basic information

• Product Name: Ethanone, 1-(3-fluoropyrazinyl)- (9CI)
• Synonyms: Ethanone, 1-(3-fluoropyrazinyl)- (9CI)
• CAS NO: 206278-28-6
• Molecular Formula: C6H5FN2O
• Molecular Weight: 140.1151032
• Product Categories: ACETYLGROUP
• Mol File: 206278-28-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanone, 1-(3-fluoropyrazinyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(3-fluoropyrazinyl)- (9CI)(206278-28-6)
• EPA Substance Registry System: Ethanone, 1-(3-fluoropyrazinyl)- (9CI)(206278-28-6)

Safety Data

• Hazardous Substances Data: 206278-28-6(Hazardous Substances Data)

Upstream product

• 127-19-5 N,N-dimethyl acetamide 
• 4949-13-7 2-fluoropyrazine 
• 206278-18-4 2-fluoro-3-(1-hydroxyethyl)pyrazine 

Relevant articles and documents

IRE1 KINASE INHIBITORS AND USES THEREOF

Disclosed herein are, inter alia, compounds modulating Inositol-Requiring Enzyme 1α (IRE1α) and IRE1β activity and methods of use thereof for treating IRE1α-mediated and IRE1β-mediated disorders.

Functionalization by metallation of fluoropyrazine. Diazines XXI

Lithiation of fluoropyrazine followed by quenching with various electrophiles was successfully achieved and was used to synthesize new pyrazine derivatives. A further lithiation of 2-fluoro-3-substitute, pyrazines allowed access to 2,3,6-trisubstituted pyridazine derivatives. As an application, a one-pot synthesis of a quinuclidinylfluoropyrazine has been performed. When the 3-substituent bears a TMS protected alcohol, functionalization via metallation at C6 position provides tetrasubstituted pyrazines in good yield.