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N-butyl-1-methyl-4-{[(1-methyl-4-{[(1-methyl-4-{[(3-methyl-6-nitro-2,4-dioxo-3,4-dihydropyrimido[4,5-b]quinolin-10(2H)-yl)acetyl]amino}-1H-pyrrol-2-yl)carbonyl]amino}-1H-pyrrol-2-yl)carbonyl]amino}-1H-pyrrole-2-carboxamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

207128-62-9

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  • N-butyl-1-methyl-4-{[(1-methyl-4-{[(1-methyl-4-{[(3-methyl-6-nitro-2,4-dioxo-3,4-dihydropyrimido[4,5-b]quinolin-10(2H)-yl)acetyl]amino}-1H-pyrrol-2-yl)carbonyl]amino}-1H-pyrrol-2-yl)carbonyl]amino}-1H-pyrrole-2-carboxamide

    Cas No: 207128-62-9

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  • N-butyl-1-methyl-4-{[(1-methyl-4-{[(1-methyl-4-{[(3-methyl-6-nitro-2,4-dioxo-3,4-dihydropyrimido[4,5-b]quinolin-10(2H)-yl)acetyl]amino}-1H-pyrrol-2-yl)carbonyl]amino}-1H-pyrrol-2-yl)carbonyl]amino}-1H-pyrrole-2-carboxamide

    Cas No: 207128-62-9

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207128-62-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 207128-62-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,7,1,2 and 8 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 207128-62:
(8*2)+(7*0)+(6*7)+(5*1)+(4*2)+(3*8)+(2*6)+(1*2)=109
109 % 10 = 9
So 207128-62-9 is a valid CAS Registry Number.

207128-62-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name N-[5-[[5-(butylcarbamoyl)-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-1-methyl-4-[[2-(3-methyl-6-nitro-2,4-dioxopyrimido[4,5-b]quinolin-10-yl)acetyl]amino]pyrrole-2-carboxamide

1.2 Other means of identification

Product number -
Other names N-butyl-1-methyl-4-(1-methyl-4-{1-methyl-4-[(3-methyl-6-nitro-5-deazaflavin-10-yl)methylcarboxamido]pyrrole-2-carboxamido}pyrrole-2-carboxamido)pyrrole-2-carboxamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:207128-62-9 SDS

207128-62-9Downstream Products

207128-62-9Relevant articles and documents

Synthesis and evaluation of nitro 5-deazaflavinpyrrolecarboxamide(s) hybrid molecules as novel DNA targeted bioreductive antitumor agents

Kanaoka, Yoshitomo,Ikeuchi, Yoshihiro,Kawamoto, Tetsuji,Bessho, Kiyoshi,Akimoto, Naoshige,Mikata, Yuji,Nishida, Mamiko,Yano, Shigenobu,Sasaki, Takuma,Yoneda, Fumio

, p. 301 - 314 (2007/10/03)

A series of 6-nitro-5-deazaflavins bearing at N(3) or N(10) position the pyrrolecarboxamide(s) group as DNA minor groove binder has been synthesized. These hybrid molecules show similar redox properties to those of 6-nitro-5- deazaflavins with no pyrrolecarboxamide(s) group, suggesting that they generate stable one- and two-electron reduction product(s). Electrolytic reductions of the hybrid molecules were carried out at a controlled potential under anaerobic conditions in the presence of plasmid pBR322 DNA. Significant conversions of the supercoiled circular pBR322 DNA (form I) to the open circular DNA (form II) have been found by treatment with the reductively activated 6-nitro-5-deazaflavin derivatives. Their DNA damaging effects have been found to be enhanced as the number of pyrrolecarboxamide group as the DNA binder increases. Antitumor activities of the hybrid molecules towards KB and L1210 cells were evaluated in vitro. It has been found that the antitumor effects of the compounds on KB cells slightly change and those on L1210 cells decrease as the number of the pyrrolecarboxamide group increases. These results reveal that the combination of 6-nitro-5-deazaflavin molecule with the pyrrolecarboxamide(s) group increase the DNA binding properties of the compounds, giving rise to promoted DNA damaging effects, and also suggest that the combination would affect the capacity of the compounds to act as the substrate for intracellular reductases and/or the cellular uptake of the compounds.

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