1644-82-2

Basic information

• Product Name: 2-FLUORO-6-NITROBENZALDEHYDE
• Synonyms: 2-FLUORO-6-NITROBENZALDEHYDE;2-Fluoro-6-nitrobenzaldehyde 99%;3-Fluoro-2-formylnitrobenzene;2-Fluoro-6-nitrobenzaldehyde99%;2-FLUORO-6-NITROBENZAL
• CAS NO: 1644-82-2
• Molecular Formula: C₇H₄FNO₃
• Molecular Weight: 169.11
• Product Categories: Aromatic Aldehydes & Derivatives (substituted);Benzene series
• Mol File: 1644-82-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 62-63℃
• Boiling Point: 287℃
• Flash Point: 127℃
• Appearance: /
• Density: 1.443
• Vapor Pressure: 0.00257mmHg at 25°C
• Refractive Index: 1.59
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-FLUORO-6-NITROBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-6-NITROBENZALDEHYDE(1644-82-2)
• EPA Substance Registry System: 2-FLUORO-6-NITROBENZALDEHYDE(1644-82-2)

Safety Data

• Hazardous Substances Data: 1644-82-2(Hazardous Substances Data)

Usage

General Description

2-Fluoro-6-nitrobenzaldehyde is a chemical compound consisting of a benzene ring with a fluorine atom at the 2-position and a nitro group at the 6-position, as well as an aldehyde functional group. 2-Fluoro-6-nitrobenzaldehyde is commonly used in organic synthesis and medicinal chemistry. It is known for its ability to act as a building block in the production of various pharmaceuticals and agrochemicals. Additionally, 2-Fluoro-6-nitrobenzaldehyde has been studied for its potential as an anti-inflammatory and anti-cancer agent. However, it is important to handle this compound with caution as it is considered hazardous and may cause skin and eye irritation.

InChI:InChI=1/C7H4FNO3/c8-6-2-1-3-7(9(11)12)5(6)4-10/h1-4H

Upstream product

• 82420-35-7 2-(bromomethyl)-4-fluoro-1-nitrobenzene 
• 446-10-6 2-nitro-4-fluorotoluene 
• 769-10-8 1-fluoro-2-methyl-3-nitrobenzene 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 1643-60-3 (2-fluoro-6-nitrophenyl)methanol 
• 13664-71-6 C₁₅H₁₄FN₃O₃ 
• 1958-93-6 2-(bromomethyl)-1-fluoro-3-nitrobenzene 

Downstream Products

• 1644-15-1 1-fluoro-3-nitro-2-(2-nitro-vinyl)-benzene 
• 34084-87-2 methyl 4-nitrobenzo[b]thiophene-2-carboxylate 
• 19995-46-1 4-nitro-benzo[b]thiophene-2-carboxylic acid 

Relevant articles and documents

6-Fluorophenylbenzohydrazides inhibit Mycobacterium tuberculosis growth through alteration of tryptophan biosynthesis

A major constraint in reducing tuberculosis epidemic is the emergence of strains resistant to one or more of clinically approved antibiotics, which emphasizes the need of novel drugs with novel targets. Genetic knockout strains of Mycobacterium tuberculosis (Mtb) have established that tryptophan (Trp) biosynthesis is essential for the bacterium to survive in vivo and cause disease in animal models. An anthranilate-like compound, 6-FABA, was previously shown to synergize with the host immune response to Mtb infection in vivo. Herein, we present a class of anthranilate-like compounds endowed with good antimycobacterial activity and low cytotoxicity. We show how replacing the carboxylic moiety with a hydrazide led to a significant improvement in both activity and cytotoxicity relative to the parent compound 6-FABA. Several new benzohydrazides (compounds 20–31, 33, 34, 36, 38 and 39) showed good activities against Mtb (0.625 ≤ MIC≤6.25 μM) and demonstrated no detectable cytotoxicity against Vero cell assay (CC50 ≥ 1360 μM). The target preliminary studies confirmed the hypothesis that this new class of compounds inhibits Trp biosynthesis. Taken together, these findings indicate that fluorophenylbenzohydrazides represent good candidates to be assessed for drug discovery.

A highly selective tandem cross-coupling of gem-dihaloolefins for a modular, efficient synthesis of highly functionalized indoles

(Chemical Equation Presented) A highly efficient method of indole synthesis using gem-dihalovinylaniline substrates and an organoboron reagent was developed via a Pd-catalyzed tandem intramolecular amination and an intermolecular Suzuki coupling. Aryl, alkenyl, and alkyl boron reagents are all successfully employed, making for a versatile modular approach. The reaction tolerates a variety of substitution patterns on the aniline leading to indoles with group at C2-C7. The orthogonal approach of the sequential copper- and palladium-mediated synthesis of 1,2-diarylindoles exploited the wide availability of diverse organoboron reagents.

Substituted Dihydroquinazolines II

The invention relates to substituted dihydroquinazolines and to a method for the production thereof, the use thereof for treating and/or preventing diseases and for producing drugs for treating and/or preventing diseases, in particular for the use of the inventive dihydroquinazolines in the form of antiviral agents, in particular against cytomegaloviruses.