1644-82-2

Basic information

• Product Name: 2-FLUORO-6-NITROBENZALDEHYDE
• Synonyms: 2-FLUORO-6-NITROBENZALDEHYDE;2-Fluoro-6-nitrobenzaldehyde 99%;3-Fluoro-2-formylnitrobenzene;2-Fluoro-6-nitrobenzaldehyde99%;2-FLUORO-6-NITROBENZAL
• CAS NO: 1644-82-2
• Molecular Formula: C₇H₄FNO₃
• Molecular Weight: 169.11
• Product Categories: Aromatic Aldehydes & Derivatives (substituted);Benzene series
• Mol File: 1644-82-2.mol

Chemical Properties

• Melting Point: 62-63℃
• Boiling Point: 287℃
• Flash Point: 127℃
• Appearance: /
• Density: 1.443
• Vapor Pressure: 0.00257mmHg at 25°C
• Refractive Index: 1.59
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-FLUORO-6-NITROBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-6-NITROBENZALDEHYDE(1644-82-2)
• EPA Substance Registry System: 2-FLUORO-6-NITROBENZALDEHYDE(1644-82-2)

Safety Data

• Hazardous Substances Data: 1644-82-2(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2-Fluoro-6-nitrobenzaldehyde is used as a key intermediate in organic synthesis for the production of various compounds, leveraging its unique structural features to facilitate the formation of complex organic molecules.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-Fluoro-6-nitrobenzaldehyde is utilized as a building block for the development of pharmaceuticals, contributing to the creation of new drugs with potential therapeutic applications.
Used in Pharmaceutical Production:
2-Fluoro-6-nitrobenzaldehyde is used as a precursor in the synthesis of pharmaceuticals, playing a crucial role in the development of new medications with diverse therapeutic profiles.
Used in Agrochemical Production:
2-Fluoro-6-nitrobenzaldehyde is also employed in the production of agrochemicals, where it serves as a starting material for the synthesis of various agrochemical products designed to protect crops and enhance agricultural productivity.
Used in Anti-inflammatory Research:
2-Fluoro-6-nitrobenzaldehyde is used as a subject of research in anti-inflammatory applications, exploring its potential to modulate inflammatory pathways and provide relief from inflammation-related conditions.
Used in Anti-cancer Research:
In anti-cancer research, 2-Fluoro-6-nitrobenzaldehyde is studied for its potential to inhibit cancer cell growth and proliferation, offering a promising avenue for the development of novel cancer therapeutics.
Used in Hazardous Material Handling:
Due to its hazardous nature, 2-Fluoro-6-nitrobenzaldehyde is also a subject of study in the field of hazardous material handling, focusing on the development of safe handling procedures and protective measures to minimize health risks during its use in laboratories and industrial settings.

InChI:InChI=1/C7H4FNO3/c8-6-2-1-3-7(9(11)12)5(6)4-10/h1-4H

Upstream product

• 82420-35-7 2-(bromomethyl)-4-fluoro-1-nitrobenzene 
• 769-10-8 1-fluoro-2-methyl-3-nitrobenzene 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 1958-93-6 2-(bromomethyl)-1-fluoro-3-nitrobenzene 
• 1643-60-3 (2-fluoro-6-nitrophenyl)methanol 
• 13664-71-6 C₁₅H₁₄FN₃O₃ 
• 446-10-6 2-nitro-4-fluorotoluene 

Downstream Products

• 302897-04-7 10-(6-hydroxy-hexyl)-6-nitro-3-phenyl-10H-pyrimido[4,5-b]quinoline-2,4-dione 
• 34084-87-2 methyl 4-nitrobenzo[b]thiophene-2-carboxylate 
• 19995-46-1 4-nitro-benzo[b]thiophene-2-carboxylic acid 

Relevant articles and documents

6-Fluorophenylbenzohydrazides inhibit Mycobacterium tuberculosis growth through alteration of tryptophan biosynthesis

A major constraint in reducing tuberculosis epidemic is the emergence of strains resistant to one or more of clinically approved antibiotics, which emphasizes the need of novel drugs with novel targets. Genetic knockout strains of Mycobacterium tuberculosis (Mtb) have established that tryptophan (Trp) biosynthesis is essential for the bacterium to survive in vivo and cause disease in animal models. An anthranilate-like compound, 6-FABA, was previously shown to synergize with the host immune response to Mtb infection in vivo. Herein, we present a class of anthranilate-like compounds endowed with good antimycobacterial activity and low cytotoxicity. We show how replacing the carboxylic moiety with a hydrazide led to a significant improvement in both activity and cytotoxicity relative to the parent compound 6-FABA. Several new benzohydrazides (compounds 20–31, 33, 34, 36, 38 and 39) showed good activities against Mtb (0.625 ≤ MIC≤6.25 μM) and demonstrated no detectable cytotoxicity against Vero cell assay (CC50 ≥ 1360 μM). The target preliminary studies confirmed the hypothesis that this new class of compounds inhibits Trp biosynthesis. Taken together, these findings indicate that fluorophenylbenzohydrazides represent good candidates to be assessed for drug discovery.

1,2,4-OXADIAZOLE SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS

The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts, stereoisomers or tautomers thereof which are inhibitors of the Sonic Hedgehog pathway, in particular Smo antagonists. Thus the compounds of this invention are useful for the treatment of diseases associated with abnormal hedgehog pathway activation, including cancer, for example basal cell carcinoma, medulloblastoma, prostate, pancreatic, breast, colon, bone and small cell lung cancers, and cancers of the upper GI tract.

A highly selective tandem cross-coupling of gem-dihaloolefins for a modular, efficient synthesis of highly functionalized indoles

(Chemical Equation Presented) A highly efficient method of indole synthesis using gem-dihalovinylaniline substrates and an organoboron reagent was developed via a Pd-catalyzed tandem intramolecular amination and an intermolecular Suzuki coupling. Aryl, alkenyl, and alkyl boron reagents are all successfully employed, making for a versatile modular approach. The reaction tolerates a variety of substitution patterns on the aniline leading to indoles with group at C2-C7. The orthogonal approach of the sequential copper- and palladium-mediated synthesis of 1,2-diarylindoles exploited the wide availability of diverse organoboron reagents.

Heterocyclyl-substituted dihydroquinazolines and their use as antiviral agents

The invention relates to heterocyclyl-substituted dihydroquinazolines of formula (I), to processes for their preparation, to medicaments containing them, and to methods for the treatment and/or prophylaxis of diseases, in particular, for use as anti-viral agents, in particular, against cytomegaloviruses.

Substituted Dihydroquinazolines II

The invention relates to substituted dihydroquinazolines and to a method for the production thereof, the use thereof for treating and/or preventing diseases and for producing drugs for treating and/or preventing diseases, in particular for the use of the inventive dihydroquinazolines in the form of antiviral agents, in particular against cytomegaloviruses.

SUBSTITUTED DIHYDROQUINAZOLINES II

The invention relates to substituted dihydroquinazolines and to a method for the production thereof, the use thereof for treating and/or preventing diseases and for producing drugs for treating and/or preventing diseases, in particular for the use of the inventive dihydroquinazolines in the form of antiviral agents, in particular against cytomegaloviruses.

SUBSTITUTED DIHYDROCHINAZOLINES HAVING ANTIVIRAL PROPERTIES

The invention relates to substituted dihydrochinazolines of formula (I), methods for the production thereof, and the use thereof for producing medicaments used for treating and/or preventing diseases, particularly as antiviral agents, especially against cytomegaloviruses.

HETEROCYCLYL-SUBSTITUTED DIHYDROQUINAZOLINES AND USE THEREOF AS AN ANTIVIRAL AGENT

The invention relates to heterocyclyl-substituted dihydroquinazolines of formula (I), methods for the production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular, for use as anti-viral agents, in particular, against cytomegaloviruses.

Benzothiadiazinyl-indole derivatives and their use as serotonin receptor ligands

Compounds having the formula: in which n is 1 or 2, m is 1 or 2, p is 1 to 6, q is 0 or 1 to 3, R1and R2are each hydrogen or C1-4alkyl, R3, R4and R5are each hydrogen, C1-4alkyl, optionally substituted phenyl or optionally substituted phenyl-C1-4alkyl, or R3and R4together form an alkylene link of formula -(CH2)3- or -(CH2)4-, or R4and R5together with the carbon atom to which they are attached form a C3-6cycloalkyl group, R6is C1-4alkyl, C1-4alkoxy, carboxy, hydroxy, cyano, halo, trifluoromethyl, nitro or amino, the dotted line represents an optional double bond, and the fluorine atom is attached at the 6 or 7-position; and salts and esters thereof, are binding to the 5-HT serotonin receptor and are useful in the treatment of CNS disorders.

1H-2,1,3-benzothiadiazine-2,2-dioxide compounds or derivatives thereof

A pharmaceutical compound having the formula: STR1 in which n is 1 or 2, m is 1 or 2, p is 1 to 6, q is 0 or 1 to 3, R1 and R2 are each hydrogen or C1-4 alkyl, R3, R4 and R5 are each hydrogen, C1-4 alkyl, optionally substituted phenyl or optionally substituted phenyl-C1-4 alkyl, or R3 and R4 together form an alkylene link of formula --(CH2)3 -- or --(CH2)4 --, or R4 and R5 together with the carbon atom to which they are attached form a C3-6 cycloalkyl group, R6 is C1-4 alkyl, C1-4 alkoxy, carboxy, hydroxy, cyano, halo, trifluoromethyl, nitro or amino, the dotted line represents an optional double bond, and the fluorine atom is attached at the 6 or 7-position; and salts and esters thereof.