208108-76-3

Basic information

• Product Name: 4-PHENYL-5-(TRIFLUOROMETHYL)THIOPHENE-2-CARBOXYLIC ACID
• Synonyms: BUTTPARK 82\12-88;4-Phenyl-5-(trifluoromethyl)-2-thenoic acid, 5-Carboxy-3-phenyl-2-(trifluoromethyl)thiophene;4-PHENYL-5-(TRIFLUOROMETHYL)THIOPHENE-2-CARBOXYLIC ACID;4-phenyl-5-(trifluoromethyl)-2-thiophenecarboxylic acid
• CAS NO: 208108-76-3
• Molecular Formula: C₁₂H₇F₃O₂S
• Molecular Weight: 272.24
• Mol File: 208108-76-3.mol

Chemical Properties

• Melting Point: 130 °C
• Boiling Point: 366.5°C at 760 mmHg
• Flash Point: 175.5°C
• Appearance: /
• Density: 1.431g/cm³
• Vapor Pressure: 5.12E-06mmHg at 25°C
• Refractive Index: 1.555
• CAS DataBase Reference: 4-PHENYL-5-(TRIFLUOROMETHYL)THIOPHENE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PHENYL-5-(TRIFLUOROMETHYL)THIOPHENE-2-CARBOXYLIC ACID(208108-76-3)
• EPA Substance Registry System: 4-PHENYL-5-(TRIFLUOROMETHYL)THIOPHENE-2-CARBOXYLIC ACID(208108-76-3)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 208108-76-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Phenyl-5-(trifluoromethyl)thiophene-2-carboxylic acid is used as a pharmaceutical intermediate for the development of new drugs. Its unique chemical structure allows it to be a potential candidate for the treatment of various diseases, including cancer, inflammation, and infectious diseases. The carboxylic acid group can be used for further functionalization and modification to improve the drug's efficacy and selectivity.
Used in Agrochemical Industry:
In the agrochemical industry, 4-Phenyl-5-(trifluoromethyl)thiophene-2-carboxylic acid is used as a building block for the synthesis of novel agrochemicals, such as insecticides, herbicides, and fungicides. Its unique structure can contribute to the development of more effective and environmentally friendly agrochemicals.
Used in Material Science:
4-Phenyl-5-(trifluoromethyl)thiophene-2-carboxylic acid is used in material science for the development of new materials with specific properties. Its unique structure can be utilized to create materials with improved electrical, optical, or mechanical properties, making it suitable for applications in electronics, photonics, and other advanced technologies.
Used as a Building Block in Organic Synthesis:
4-Phenyl-5-(trifluoromethyl)thiophene-2-carboxylic acid is used as a building block in the synthesis of more complex organic molecules. Its unique structure and functional groups can be employed in various organic reactions, enabling the creation of new compounds with diverse applications in various industries.

InChI:InChI=1/C12H7F3O2S/c13-12(14,15)10-8(6-9(18-10)11(16)17)7-4-2-1-3-5-7/h1-6H,(H,16,17)

Upstream product

• 119197-24-9 3-chloro-4,4,4-trifluoro-2-phenyl-but-2-enal 
• 350-92-5 1,1,1-Trifluoro-3-phenylpropan-2-one 
• 167279-18-7 ethyl 5-(trifluoromethyl)-4-phenylthiophene-2-carboxylate 

Downstream Products

• 1201444-43-0 4-[5-(4-phenyl-5-trifluoromethyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-pyridine 
• 1201445-66-0 3-(3-methylpyridin-4-yl)-5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazole 
• 1034688-73-7 3-(1H-indol-5-yl)-5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazole 
• 1201447-81-5 3-(1H-benzo[d]imidazol-5-yl)-5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazole 
• 917873-20-2 3-(4-hydroxy-3,5-dimethyl-phenyl)-1-(4-phenyl-5-trifluoromethyl-thiophen-2-yl)-propan-1-one 
• 1236144-81-2 tert-butyl 1-(4-(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate 
• 1307231-27-1 (R)-tert-butyl (2-((tert-butyldimethylsilyl)oxy)ethyl)(4-(N-((4-phenyl-5-(trifluoromethyl)thiophene-2-carbonyl)oxy)carbamimidoyl)-2,3-dihydro-1H-inden-1-yl)carbamate 
• 1265323-31-6 2-((R)-1-((S)-2-hydroxy-2-(4-(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)acetic acid 
• 1236202-92-8 (Z)-tert-butyl 1-(4-(N'-(4-phenyl-5-(trifluoromethyl)thiophene-2-carbonyloxy)-carbamimidoyl)benzyl)azetidine-3-carboxylate 
• 1034688-87-3 4-{5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-1,2,4-oxadiazol-3-yl}-1H-indole 
• 1034188-46-9 ethyl 1-[(3-chloro-4-{5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-1,2,4-oxadiazol-3-yl}phenyl)methyl]-1H-pyrazole-3-carboxylate 
• 1034188-50-5 ethyl 1-[(2-chloro-4-{5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-1,2,4-oxadiazol-3-yl}phenyl)methyl]-1H-pyrazole-3-carboxylate 
• 217184-77-5 1-(4-phenyl-5-trifluoromethyl-thiophen-2-yl)-ethanone 
• 569685-49-0 3-[(4-carbomethoxy)phenyl]-5-(4-phenyl-5-trifluoromethyl-2-thienyl)-1,2,4-oxadiazole 

Relevant articles and documents

NOVEL THIOPHENE DERIVATIVES

The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.

A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists

Moderately potent, selective S1P1 receptor agonists identified from high-throughput screening have been adapted into lipophilic tails for a class of orally bioavailable amino acid-based S1P1 agonists represented by 7. Many of the new

Microbicidal agents based on thiophene-2-carboxylic acid derivatives

PCT No. PCT/EP97/06368 Sec. 371 Date May 26, 1999 Sec. 102(e) Date May 26, 1999 PCT Filed Nov. 14, 1997 PCT Pub. No. WO98/23605 PCT Pub. Date Jun. 4, 1998Novel microbicidal compositions based on thiophene-2-carboxylic acid derivatives, some of which are k