20942-68-1Relevant articles and documents
Oxygen-Doped PAH Electrochromes: Difurano, Dipyrano, and Furano-Pyrano Containing Naphthalene-Cored Molecules
Fletcher-Charles, Jack,Ferreira, Rúben R.,Abraham, Michael,Romito, Deborah,Oppel, Markus,González, Leticia,Bonifazi, Davide
supporting information, (2021/11/23)
In this work, we report the synthesis of O-doped naphthalene-based electrochromes. Exploiting the CuO-mediated Pummerer oxidative cycloetherification reaction, a series of 1,4- and 1,5-disubstituted naphthalene-cored dipyrano, difurano, and furano-pyrano polycyclic aromatic hydrocarbons (PAHs) have been prepared. Steady-state UV-Vis absorption and emission investigations showed that the spectroscopic profile strongly depends on the O-doping topology, with the dipyrano and the difurano derivatives demonstrating the most red-shifted and blue-shifted electronic transition, respectively. Computational investigations revealed that the cycloetherification reaction raises the HOMO energy level (while the LUMO remains largely unaffected), with the dipyrano derivatives displaying the highest values. Spectroelectrochemical measurements showed that, depending on the O-topology and the type of O-ring, different electrochromic responses could be obtained with colour transitions featuring high contrasts involving yellow, pink, orange or blue colours.
COMPOUNDS AND USES THEREOF
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Page/Page column 71; 113-114, (2021/08/06)
The present disclosure features compounds useful for the treatment of BAF complex-related disorders.
Mosquito acetylcholinesterase as a target for novel phenyl-substituted carbamates
Mutunga, James M.,Ma, Ming,Chen, Qiao-Hong,Hartsel, Joshua A.,Wong, Dawn M.,Ding, Sha,Totrov, Max,Carlier, Paul R.,Bloomquist, Jeffrey R.
, (2019/05/27)
New insecticides are needed for control of disease-vectoring mosquitoes and this research evaluates the activity of new carbamate acetylcholinesterase (AChE) inhibitors. Biochemical and toxicological characterization of carbamates based on the parent stru
Synthesis of 2-arylbenzofuran-3-carbaldehydes: via an organocatalytic [3+2] annulation/oxidative aromatization reaction
Zhang, Huiwen,Ma, Chunmei,Zheng, Ziwei,Sun, Rengwei,Yu, Xinhong,Zhao, Jianhong
supporting information, p. 4935 - 4938 (2018/05/23)
A novel organocatalytic [3+2] annulation/oxidative aromatization reaction of enals with 2-halophenols or β-naphthols is reported. This process enables chemo- and regioselective access to 2-arylbenzofuran-3-carbaldehydes without the use of transition metals or strong oxidants. Preliminary mechanistic studies reveal that an unprecedented, organocatalytic, direct α-arylation pathway is involved.
MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS
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Paragraph 00771, (2018/09/12)
Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
Small Molecules Simultaneously Inhibiting p53-Murine Double Minute 2 (MDM2) Interaction and Histone Deacetylases (HDACs): Discovery of Novel Multitargeting Antitumor Agents
He, Shipeng,Dong, Guoqiang,Wu, Shanchao,Fang, Kun,Miao, Zhenyuan,Wang, Wei,Sheng, Chunquan
supporting information, p. 7245 - 7260 (2018/08/03)
p53-Murine double minute 2 (MDM2) interaction and histone deacetylases (HDACs) are important targets in antitumor drug development. Inspired by the synergistic effects between MDM2 and HDACs, the first MDM2/HDACs dual inhibitors were identified, which sho
A practical synthesis of a cis -4,5-Bis(4-chlorophenyl)imidazoline Intermediate for Nutlin analogues
Shu, Lianhe,Wang, Ping,Liu, Wen,Gu, Chen
, p. 1866 - 1869 (2013/01/15)
A practical synthesis of cis-4,5-bis(4-chlorophenyl)imidazoline, a key intermediate for Nutlin analogues, is reported. The title compound was prepared in 81-88% yield by boric acid catalyzed direct condensation of meso-bis(4-chlorophenyl)ethane-1,2-diamine with a benzoic acid. The process was successfully scaled up in a pilot plant, resulting in >15 kg of the product.
PROCESS FOR SELECTIVELY POLYMERIZING ETHYLENE AND CATALYST THEREFOR
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Page/Page column, (2013/03/26)
The present invention generally relates to a process that selectively polymerizes ethylene in the presence of an alpha-olefin, and to a metal-ligand complex (precatalyst) and catalyst useful in such processes, and to related compositions. The present invention also generally relates to ligands and intermediates useful for preparing the metal-ligand complex and to processes of their preparation.
An efficient synthetic route to novel 3-alkyl- and 3-aryl-4-iodophenols
Hermann, Gesine J.,Annis, Michael C.,Edwards, Peter D.,Corrales, Marta,Diaz, Lucia,Goodnow, Robert A.
, p. 221 - 224 (2008/12/20)
An efficient method for the preparation of novel 3-alkyl-and 3-aryl-4-iodophenols from 3-alkyl- and 3-arylphenols is described. Georg Thieme Verlag Stuttgart.
HETEROCYCLIC NON-PEPTIDE GNRH ANTAGONISTS
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Page/Page column 65, (2008/06/13)
A compound of formula (I): wherein either B is absent and A and Z are the same or different and are each hydrogen, halogen, alkyl, hydroxy, alkoxy,-CN,-C(Rc)2OH,-N(Rd)C(=X)Rc,-C(=X)N(Rc)(Rd),-S(O)m-Rc,-N(Rc)(Rd)S(O)2,-S(O)2N(R c)(Rd),-N(Re)2, aryl optionally substituted with Ra or-O-aryl optionally substituted with Ra; or B is present and is-(CH2)n-,-C(Rb)2-or-O-, or B taken together with A or Z can be-C=C(Rb)-,-C(Rb)=C-,-CH2-CH(R b)-or-CH(Rb)-CH2-; D is-O-or-S(O) m,-; E is a bond or is-(CH2)n-,-N(R d)-,-(CH2)nN(Rd)-or-N(R d)(CH2)n-; F is-C(=X)-; G is-(CH2 )n-,-N(Rd)-,-(CH2)nN(R d)-or-N(Rd)(CH2)n; J is a bond,-O-,-N(RC)C(=X)-,-C(=X)N(Rc)-,-S(O)m,-,-N(Rc)S(O)m-,-S(O)nN(Rc)-,-N(Re)-or-N(Rg)(Rh); K is a bond, alkylene, cycloalkylene, cycloalkenylene, arylene, heterocycloalkylene, heterocycloalkylene or heteroarylene; and L is hydrogen or a terminal group; has therapeutic utility.
