210558-66-0

Basic information

• Product Name: (IR,2S)-N-Pyrrolidinyl norephedrine HCL
• Synonyms: (IR,2S)-N-Pyrrolidinyl norephedrine HCL;(1R,2S)-1-Phenyl-2-(1-pyrrolidinyl)propan-1-ol hydrochloride
• CAS NO: 210558-66-0
• Molecular Formula: C₁₃H₁₉NO*ClH
• Molecular Weight: 241.757
• Mol File: 210558-66-0.mol

Chemical Properties

• Appearance: /
• Density: 1.351
• CAS DataBase Reference: (IR,2S)-N-Pyrrolidinyl norephedrine HCL(CAS DataBase Reference)
• NIST Chemistry Reference: (IR,2S)-N-Pyrrolidinyl norephedrine HCL(210558-66-0)
• EPA Substance Registry System: (IR,2S)-N-Pyrrolidinyl norephedrine HCL(210558-66-0)

Safety Data

• Hazardous Substances Data: 210558-66-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(R,2S)-N-Pyrrolidinyl norephedrine HCL is used as a nasal decongestant for the treatment of nasal congestion, providing relief by constricting blood vessels in the nasal passages and reducing swelling.
(R,2S)-N-Pyrrolidinyl norephedrine HCL is also used as a bronchodilator to alleviate respiratory issues, such as those experienced in asthma, by relaxing and widening the airways to improve airflow.
Additionally, it is utilized in the treatment of certain types of shock, where its vasoconstrictive properties help to stabilize blood pressure and improve blood flow to vital organs. However, due to the potential for misuse and overuse leading to adverse effects, it is crucial that this chemical is administered under the guidance of a healthcare professional.

Downstream Products

• 1215194-18-5 (S)-(-)-1-phenyl-2-(1-pyrrolidinyl)-1-propanone hydrochloride 
• 56571-91-6 (1R,2S)-1-phenyl-2-(1-pyrrolidinyl)-1-propanol 

Relevant articles and documents

Synthesis method of chiral compound

The invention belongs to the technical field of chemical synthesis, and relates to a synthetic method of a chiral compound, in particular to a synthetic method of (1R, 2S)-1-phenyl-2-(pyrrolidine-1-yl) propan-1-ol. According to an ingenious synthesis strategy, asymmetric reduction can be realized during carbonyl reduction, and a target compound can be directly obtained at high yield. The problem that a target compound cannot be obtained at high yield through asymmetric reduction in the prior art is solved. Moreover, the synthesis of a high-purity compound (A) can be realized by using cheap hydrochloric acid and zinc chloride; in addition, no isomer is wasted; and according to the method, the use of norephedrine controlled product is avoided; the raw materials are cheap and easy to obtain,so that the synthesis cost is reduced; moreover, the preparation method disclosed by the invention is easy for industrial large-scale production.

Efficient synthesis of a chiral mediator

An efficient method for the quantitative preparation and isolation of a compound of formula I STR1 or its enantiomer, a chiral mediator used in enantioselective synthesis.