56571-91-6

Basic information

• Product Name: (1S 2R)-1-PHENYL-2-(1-PYRROLIDINYL)-1-
• Synonyms: (1S 2R)-1-PHENYL-2-(1-PYRROLIDINYL)-1-;(1S,2R)-1-PHENYL-2-(1-PYRROLIDINYL)-1-PR;(1S,2R)-1-Phenyl-2-(1-pyrrolidinyl)-1-propanol 98%
• CAS NO: 56571-91-6
• Molecular Formula: C₁₃H₁₉NO
• Molecular Weight: 205.29606
• Product Categories: Chiral Building Blocks;Heterocyclic Building Blocks;Pyrrolidines
• Mol File: 56571-91-6.mol
• Article Data: 18

Chemical Properties

• Melting Point: 43-47 °C(lit.)
• Boiling Point: 321.3°Cat760mmHg
• Flash Point: >230 °F
• Appearance: /
• Density: 1.075g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (1S 2R)-1-PHENYL-2-(1-PYRROLIDINYL)-1-(CAS DataBase Reference)
• NIST Chemistry Reference: (1S 2R)-1-PHENYL-2-(1-PYRROLIDINYL)-1-(56571-91-6)
• EPA Substance Registry System: (1S 2R)-1-PHENYL-2-(1-PYRROLIDINYL)-1-(56571-91-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 56571-91-6(Hazardous Substances Data)

Usage

Uses

(1S,2R)-1-Phenyl-2-(1-pyrrolidinyl)-1-propanol can be used as: A chiral catalyst to prepare corresponding enantioselective secondary aromatic alcohols by the addition of dialkylzincs to aromatic aldehydes. A reactant to synthesize optically active (R)-(+)-1-phenyl-2-(1-pyrrolidinyl)-1-propanone by oxidation reaction.

Upstream product

• 210558-66-0 (1R,2S)-(+)-1-phenyl-2-(1-pyrrolidinyl)-1-propanol hydrochloride 
• 71-43-2 benzene 
• 123-75-1 pyrrolidine 
• 4436-22-0 1-phenylpropylene oxide 
• 1215194-08-3 (S)-(-)-1-phenyl-2-(1-pyrrolidinyl)-1-propanone 
• 19134-50-0 (SR)-(+/-)-1-phenyl-2-(1-pyrrolidinyl)-1-propanone 
• 173676-57-8 1-phenyl-2-(pyrrolidin-1-yl)propan-1-ol 
• 93-55-0 1-phenyl-propan-1-one 
• 110-52-1 1,4-dibromo-butane 
• 492-41-1 (1R,2S)-norephedrine 
• 37577-28-9 (1S,2R)-(+)-norphedrine 
• 628-21-7 1,4-Diiodobutane 

Downstream Products

• 592551-69-4 (1R,2S)-1-phenyl-2-pyrrolidinylpropanamine 
• 1224847-71-5 (1R,2S)-1-phenyl-2-(pyrrolidin-1-yl)propyl (2S)-5-[(tert-butoxycarbonyl)amino]-2-(4,5-dihydroimidazo[1,5-a]quinolin-3-ylmethyl)pentanoate 
• 1224847-72-6 (1R,2S)-1-phenyl-2-(pyrrolidin-1-yl)propyl (2R)-5-[(tert-butoxycarbonyl)amino]-2-(4,5-dihydroimidazo[1,5-a]quinolin-3-ylmethyl)pentanoate 
• 1224849-26-6 (1R,2S)-1-phenyl-2-(pyrrolidin-1-yl)propyl (2S)-5-[(tert-butoxycarbonyl)amino]-2-[(7-methyl-4,5-dihydroimidazo[1,5-a]quinolin-3-yl)methyl]pentanoate 
• 1239346-72-5 (2S,3R,7aR)-3-methyl-2-phenylhexahydropyrrolo[2.1-b]oxazole 
• 1403388-28-2 C₁₅H₂₀F₃NO₂Zn 
• 166031-45-4 Thioacetic acid S-((1R,2S)-1-phenyl-2-pyrrolidin-1-yl-propyl) ester 
• 209414-27-7 (2S)-2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol 

Relevant articles and documents

Enantioselective Conjugate Addition of Catalytically Generated Zinc Homoenolate

We report herein an enantioselective conjugate addition reaction of a zinc homoenolate, catalytically generated via ring opening of a cyclopropanol, to an α,β-unsaturated ketone. The reaction is promoted by a zinc aminoalkoxide catalyst generated from Et2Zn and a chiral β-amino alcohol to afford 1,6-diketones, which undergo, upon heating, intramolecular aldol condensation to furnish highly substituted cyclopentene derivatives with good to high enantioselectivities. The reaction has proved applicable to various 1-substituted cyclopropanols as well as chalcones and related enones. The chiral amino alcohol has proved to enable ligand-accelerated catalysis of the homoenolate generation and its conjugate addition. Positive nonlinear effects and lower reactivity of a racemic catalyst have been observed, which can be attributed to a stable and inactive heterochiral zinc aminoalkoxide dimer.

Method for preparing chiral (1R,2S)-1-phenyl-2-(1-pyrrolidyl)propane-1-alcohol

The invention provides a new method for simply and feasibly synthesizing (1R,2S)-1-phenyl-2-(1-pyrrolidyl)propane-1-alcohol through enzymatic catalysis. The method is easy to operate and mild in condition, an intermediate does not need to be separated, th

A (S)- N - methoxy - methyl -2 - (tetrahydro-pyrrolyl) propionamide and its preparation method and application

The invention discloses a (S)-N-methoxy-methyl-2-(pyrrolidine) propionamide shown as a formula (5). A preparation method is as follows: subjecting a starting material L-alanine to amino protection, reaction with N,O-dimethyl hydroxylamine hydrochloride, removal of amino protecting group, and alkylation; and subjecting the prepared compound shown as (5) to addition elimination and reduction to obtain an Efavirenz chiral ligand shown as the formula (7). The synthetic method of Efavirenz chiral ligand provided by the invention has the advantages of mild reaction conditions, simple operation, high yield and low production cost, and is suitable for industrialized production.