212688-51-2

Basic information

• Product Name: FMOC-D-SER(TRT)-OH
• Synonyms: N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-O-TRITYL-D-SERINE;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-O-TRITYL-D-SERINE;N-ALPHA-FMOC-O-TRITYL-D-SERINE;FMOC-D-SER(TRT)-OH;FMOC-O-TRITYL-D-SERINE;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(triphenylmethyl)-D-serine;Fmoc-O-trityl-D-serine≥ 98% (HPLC);(9H-Fluoren-9-yl)MethOxy]Carbonyl D-Ser(Trt)-OH
• CAS NO: 212688-51-2
• Molecular Formula: C37H31NO5
• Molecular Weight: 569.65
• Product Categories: Amino Acids
• Mol File: 212688-51-2.mol

Chemical Properties

• Appearance: /Solid
• Storage Temp.: -20°C
• CAS DataBase Reference: FMOC-D-SER(TRT)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-D-SER(TRT)-OH(212688-51-2)
• EPA Substance Registry System: FMOC-D-SER(TRT)-OH(212688-51-2)

Safety Data

• Hazardous Substances Data: 212688-51-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
FMOC-D-SER(TRT)-OH is used as a building block for the synthesis of peptides and proteins. Its application reason is to facilitate the development of new drugs and therapies by providing a stable and easily modifiable structure for peptide synthesis.
Used in Chemical Synthesis:
FMOC-D-SER(TRT)-OH is used as a reagent in chemical synthesis for the production of various compounds. Its application reason is to offer a protected form of D-Serine, which can be selectively deprotected and utilized in the synthesis of complex molecules.
Used in Research and Development:
FMOC-D-SER(TRT)-OH is used as a research tool for studying the properties and interactions of amino acids in biological systems. Its application reason is to provide insights into the role of D-amino acids in peptide and protein structures, as well as their potential therapeutic applications.
Used in Peptide Chemistry:
FMOC-D-SER(TRT)-OH is used as a protected amino acid in the solid-phase peptide synthesis (SPPS) process. Its application reason is to protect the D-Serine residue during the synthesis, allowing for the stepwise assembly of peptides with controlled side-chain functionalization.

Upstream product

• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 25840-83-9 O-trityl-serine 

Downstream Products

• 87867-02-5 Fmoc-L-Asp(O-t-Bu)-L-Phe-OH 
• 873951-96-3 Me₂Leu-Ser-MeLeu-MePhe-OH 
• 873951-99-6 Me₂Leu-Ser(Me₂Leu-Ser-MeLeu-MePhe)-MeLeu-MePhe-OH 

Relevant articles and documents

Application of the Trt and Fmoc Groups for the Protection of Polyfunctional α-Amino Acids

Simple methods for the preparation of ditrityl amino acids 3 and their application for the synthesis of the peptides 9-27 are described.Selective detritylation of 3 and of the synthesized ditrityl peptides is achieved with 1percent trifluoroacetic acid in dichloromethane.The resulting Nα-detritylated amino acids 5 were converted into the corresponding fluorenylmethoxycarbonyl amino acids 6 under Schotten-Baumann conditions using fluorenylmethyl chloroformate.