Novel complex n-heterocycles via intramolecular 1,5-electrocyclizations: l,2,4,4a,5,5a,10-octahydropyrido[4",3":2',3']cyclobuta[1',2':4,5] pyrrolo[2,3-b]pyridines
The synthesis of 2-amino-3-isopropenylpyridine (5) and 2-amino-5-chloro-3-isopropenylpyridine (6) and their toluenesulfonic acid catalyzed reactions in refluxing toluene with some 1-substituted piperidin-4-ones are described. The toluenesulfonic acid cata
Nickel/Photo-Cocatalyzed Asymmetric Acyl-Carbamoylation of Alkenes
An unprecedented asymmetric acyl-carbamoylation of pendant alkenes tethered on aryl carbamic chlorides with both aliphatic and aromatic aldehydes has been developed via the cooperative catalysis of a chiral nickel-PHOX complex and tetrabutylammonium decatungstate. This reaction represents the first example of merging hydrogen-atom-transfer photochemistry and asymmetric transition metal catalysis in difunctionalization of alkenes. Using this protocol, a variety of oxindoles bearing a challenging quaternary stereogenic center are furnished under mild conditions in highly enantioselective manner.
Fan, Pei,Lan, Yun,Zhang, Chang,Wang, Chuan
p. 2180 - 2186
(2020/03/03)
KRAS G12C INHIBITORS AND METHODS OF USING THE SAME
Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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Paragraph 0652
(2019/11/19)
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