213923-81-0

Basic information

• Product Name: 1-N-BOC-3-HYDROXY-3-PHENYLPIPERIDINE
• Synonyms: 1-BOC-3-PHENYL-3-HYDROXYPIPERIDINE;1-N-BOC-3-HYDROXY-3-PHENYLPIPERIDINE;tert-butyl 3-hydroxy-3-phenylpiperidine-1-carboxylate;N-BOC-3-hydroxy-3-phenylpiperidine;N-tert-Butoxycarbonyl-3-phenylpiperidin-3-ol
• CAS NO: 213923-81-0
• Molecular Formula: C₁₆H₂₃NO₃
• Molecular Weight: 277.362
• Mol File: 213923-81-0.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-N-BOC-3-HYDROXY-3-PHENYLPIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-N-BOC-3-HYDROXY-3-PHENYLPIPERIDINE(213923-81-0)
• EPA Substance Registry System: 1-N-BOC-3-HYDROXY-3-PHENYLPIPERIDINE(213923-81-0)

Safety Data

• Hazardous Substances Data: 213923-81-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-N-BOC-3-HYDROXY-3-PHENYLPIPERIDINE is used as a precursor in the synthesis of new drugs for its potential analgesic or antipsychotic properties. Its unique structure allows for the development of compounds that can target specific receptors or pathways in the body, offering potential therapeutic benefits for pain management or the treatment of psychiatric disorders.
Used in Medicinal Chemistry Research:
1-N-BOC-3-HYDROXY-3-PHENYLPIPERIDINE serves as an interesting target for researchers in the field of medicinal chemistry. Its structure and properties provide a foundation for exploring new chemical modifications and potential applications in drug discovery. By studying this compound, scientists can gain insights into the design and synthesis of novel pharmaceutical agents with improved efficacy and safety profiles.

Upstream product

• 108-86-1 bromobenzene 
• 98977-36-7 3-oxo-piperidine-1-carboxylic acid tert-butyl ester 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 213923-82-1 2-chloro-4-(5-phenyl-1,2,3,6-tetrahydropyridino)-6-methylpyrimidine 
• 23396-50-1 3-hydroxy-3-phenylpiperidine 
• 213923-83-2 2-(2-bromo-4-isopropylanilino)-4-(5-phenyl-1,2,3,6-tetrahydropyridino)-6-methylpyrimidine 
• 1056971-31-3 tert-butyl 5-phenyl-3,6-dihydro-2H-pyridine-1-carboxylate 

Relevant articles and documents

CHIRAL AUXILIARIES

Chiral auxiliaries useful for efficiently producing a phosphorus atom-modified nucleic acid derivative with high stereoregularity, and compounds represented by the following the general formula (I) or the general formula (XI) for introducing the chiral auxiliaries.

Synthesis and structure-affinity relationships of 4-(5-Aryl-1,2,3,6-tetrahydropyridino)pyrimidine derivatives as corticotropin-releasing factor1 receptor antagonists

Recently, various non-peptide corticotropin-releasing factor1 (CRF1) receptor antagonists have been reported. Structure-affinity relationships (SARs) of non-peptide CRF1 antagonists suggest that such antagonists can be constructed of three units: a hydrophobic unit (Up-Area), a proton accepting unit (Central-Area), and an aromatic unit (Down-Area). We previously presented 4-aryl-1,2,3,6-tetrahydropyridinopyrimidine derivatives including potent CRF receptor ligands 1a and 1b and proposed that the 4-aryl-1,2,3,6-tetrahydropyridino moiety might be useful as a substituent in the Up-Area. Our interest shifted to 5-aryl-1,2,3,6-tetrahydropyridinopyrimidine derivatives 2, among which compound 2m (CRA0165) had highest affinity for CRF1 receptors (IC50=11 nM). We report here the design, synthesis and SARs of derivatives 2.

4-Tetrahydropyridylpyrimidine derivatives

A 4-tetrahydropyridylpyrimidine compound represented by formula (I): wherein Ar represents a phenyl group substituted with 1 to 3 substituents selected from a halogen atom, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon at