23396-50-1

Usage

Uses

Used in Pharmaceutical Research and Development:
3-Hydroxy-3-phenyl-piperidine is used as a key intermediate in the synthesis of various pharmaceutical compounds for its ability to interact with biological targets such as receptors and enzymes. This interaction is crucial for the development of new drugs with specific therapeutic effects.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 3-hydroxy-3-phenyl-piperidine is used as a building block for the synthesis of complex organic molecules with targeted biological activities. Its structural features allow for the creation of molecules with potential applications in treating various diseases and conditions.
Used in Drug Discovery:
3-Hydroxy-3-phenyl-piperidine is utilized in drug discovery processes to identify and develop new therapeutic agents. Its unique properties make it a valuable compound for exploring novel drug candidates that can address unmet medical needs.
Used in the Synthesis of Complex Organic Molecules:
3-Hydroxy-3-phenyl-piperidine serves as a starting material for the synthesis of more complex organic molecules with specific biological activities. Its versatility in chemical reactions enables the creation of a wide range of compounds with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.

InChI:InChI=1/C11H15NO/c13-11(7-4-8-12-9-11)10-5-2-1-3-6-10/h1-3,5-6,12-13H,4,7-9H2

Upstream product

• 98977-36-7 3-oxo-piperidine-1-carboxylic acid tert-butyl ester 
• 100-58-3 phenylmagnesium bromide 
• 213923-81-0 N-tert-butoxycarbonyl-3-hydroxy-3-phenylpiperidine 
• 100-59-4 phenylmagnesium chloride 
• 40114-49-6 1-benzyl-3-piperidone 
• 58879-07-5 N-benzyl-3-hydroxy-3-phenylpiperidine 

Downstream Products

• 188024-82-0 (4-Butyl-phenyl)-(3-hydroxy-3-phenyl-piperidin-1-yl)-methanone 
• 188024-78-4 (3,4-Dibromo-phenyl)-(3-hydroxy-3-phenyl-piperidin-1-yl)-methanone 
• 188024-86-4 (3,4-Dinitro-phenyl)-(3-hydroxy-3-phenyl-piperidin-1-yl)-methanone 
• 188024-84-2 (3-Chloro-phenyl)-(3-hydroxy-3-phenyl-piperidin-1-yl)-methanone 
• 188024-74-0 N-benzoyl-3-hydroxy-3-phenylpiperidine 
• 188024-83-1 (4-Chloro-phenyl)-(3-hydroxy-3-phenyl-piperidin-1-yl)-methanone 
• 188024-80-8 Biphenyl-4-yl-(3-hydroxy-3-phenyl-piperidin-1-yl)-methanone 
• 188024-76-2 (3-Hydroxy-3-phenyl-piperidin-1-yl)-(4-nitro-phenyl)-methanone 
• 188024-75-1 (3,4-Dichloro-phenyl)-(3-hydroxy-3-phenyl-piperidin-1-yl)-methanone 
• 188024-79-5 (3-Hydroxy-3-phenyl-piperidin-1-yl)-(4-iodo-phenyl)-methanone 
• 188024-81-9 (4-tert-Butyl-phenyl)-(3-hydroxy-3-phenyl-piperidin-1-yl)-methanone 
• 188024-85-3 (3,4-Dimethyl-phenyl)-(3-hydroxy-3-phenyl-piperidin-1-yl)-methanone 
• 77810-12-9 N-isopropyl-3-hydroxy-3-phenylpiperidine hydrochloride 
• 61192-67-4 1-methyl-3-(p-nitrophenyl)-3-piperidinol 

Relevant academic research and scientific papers

CHIRAL AUXILIARIES

Chiral auxiliaries useful for efficiently producing a phosphorus atom-modified nucleic acid derivative with high stereoregularity, and compounds represented by the following the general formula (I) or the general formula (XI) for introducing the chiral auxiliaries.

Novel piperidyl derivatives of quinazoline and isoquinoline

The invention pertains to new piperidyl-substituted quinazoline and isoquinoline derivatives that serve as effective phosphodiesterase (PDE) inhibitors. The invention also relates to compounds that are selective inhibitors of PDE10. The invention further relates to intermediates for preparation of such compounds; pharmaceutical compositions comprising such compounds; and the use of such compounds in methods for treating certain central nervous system (CNS) or other disorders.

Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D4 receptor agonists

A series of 3-aryl piperidine analogs with 2-piperidinoalkylamino or 2-piperidinoalkyloxy fused bicyclic rings were prepared and found to be potent and efficacious human dopamine D4 agonists. The synthesis and structure-activity relationship (SAR) studies that led to the identification of these compounds are discussed.

An efficient synthesis of N-aroyl-3-phenyltetrahydropyridines

N-Aroyl-3-phenyltetrahydropyridines were conveniently synthesized by dehydration of N-aroyl-3-hydroxy-3-phenylpiperidines with toluenesulfonic acid on silica gel as a dehydration reagent.