21397-08-0

Basic information

• Product Name: 2-Chloro-3-fluoroaniline
• Synonyms: BUTTPARK 44\01-95;2-CHLORO-3-FLUOROANILINE;2-Chloro-3-fluoroaniline 98%;2-Chloro-3-fluoroaniline98%;(2-chloro-3-fluoro-phenyl)amine;2-Chloro-3-fluoroaniline, 95+%
• CAS NO: 21397-08-0
• Molecular Formula: C₆H₅ClFN
• Molecular Weight: 145.56
• EINECS: 244-366-1
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds;Fluorobenzene;Aniline;API intermediates;Benzenes
• Mol File: 21397-08-0.mol

Chemical Properties

• Boiling Point: 210.3 °C at 760 mmHg
• Flash Point: 81 °C
• Appearance: /
• Density: 1.349 g/cm³
• Vapor Pressure: 2.99E-05mmHg at 25°C
• Refractive Index: 1.592
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 1?+-.0.10(Predicted)
• CAS DataBase Reference: 2-Chloro-3-fluoroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-3-fluoroaniline(21397-08-0)
• EPA Substance Registry System: 2-Chloro-3-fluoroaniline(21397-08-0)

Safety Data

• Hazard Codes: Xi,T
• Statements: 23/24/25
• Safety Statements: 36/37/39-45
• Hazardous Substances Data: 21397-08-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-3-fluoroaniline is used as an intermediate in the synthesis of various pharmaceuticals for its unique chemical properties that can be further modified to create active pharmaceutical ingredients.
Used in Dye Industry:
In the dye industry, 2-Chloro-3-fluoroaniline is used as a precursor for the production of dyes, where its specific molecular structure contributes to the color and properties of the final dye products.
Used in Agrochemical Industry:
2-Chloro-3-fluoroaniline is utilized in the development of agrochemicals, such as pesticides and herbicides, where its chemical structure can be tailored to target specific pests or weeds while minimizing environmental impact.

InChI:InChI=1/C6H5BrFNO2S/c7-4-1-2-6(5(8)3-4)12(9,10)11/h1-3H,(H2,9,10,11)

Upstream product

• 1287791-75-6 N-(2-chloro-3-fluorophenyl)-2-hydroxy-2-methylpropanamide 
• 402-67-5 3-fluoro-1-nitrobenzene 
• 205187-05-9 3-fluorophenyl N,N-diethyl-O-carbamate 
• 95-51-2 o-chloroaniline 
• 59255-94-6 2-bromo-3-fluoronitrobenzene 
• 7772-99-8 stannous chloride 
• 102940-86-3 3-chloro-3-fluorobenzoic acid 
• 602-03-9 2,3-dinitroaniline 
• 21397-07-9 2-chloro-3-fluoro-nitrobenzene 
• 1287791-65-4 2-(2-chloro-3-fluorophenoxy)-2-methylpropanamide 
• 863870-76-2 O-2-chloro-3-fluorophenyl N,N-diethylcarbamate 
• 863870-86-4 2-chloro-3-fluorophenol 

Downstream Products

• 1146413-08-2 2-chloro-3-(4-morpholinyl)aniline 
• 1138218-48-0 (2-chloro-3-fluorophenyl)hydrazine 
• 1070892-66-8 N-(3-fluoro-2-chloro-phenyl)formamide 
• 1070890-68-4 4-chloro-N-(2-chloro-3-fluoro-phenyl)-N-methyl-3-(6-methyl-2-oxo-4-trifluoromethyl-2H-pyrimidin-1-yl)-benzamide 
• 1070892-67-9 N-methyl-2-chloro-3-fluoroaniline 

Relevant articles and documents

Approaches to the synthesis of 2,3-dihaloanilines. Useful precursors of 4-functionalized-1 H-indoles

2,3-Dihaloanilines have been proved as useful starting materials for synthesizing 4-halo-1H-indoles. Subsequent or in situ functionalization of the prepared haloindoles allows the access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles in good overall yields. As no efficient synthetic routes to 2,3-dihaloanilines have been described in the literature, different approaches to the preparation of these 1,2,3-functionalized aromatic precursors are now presented. The most general one involves a Smiles rearrangement from the corresponding 2,3-dihalophenols and allows the preparation of 2,3-dihaloanilides in a straightforward and synthetically useful manner.

Il-8 receptor anatagonists

This invention relates to novel compounds of Formula (I), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).

Hydroxy diphenyl urea sulfonamides as IL-8 receptor antagonists

Novell IL-8 compounds and methods of using them are provided.

Process for the preparation of fluoroaromatic and fluoroheteroaromatic compounds

Good yields of a range of fluoroaromatic and fluoroheteroaromatic compounds may be obtained by reacting an aromatic or a heteroaromatic amine with a nitrosyl polyfluoro salt in an inert solvent to form an intermediate aryl or heteroaryl diazonium polyfluoro salt and decomposing this aryl or heteroaryl diazonium polyfluoro salt in situ. The process described is especially suitable for the preparation in good yield of fluoroaromatic and fluoroheteroaromatic compounds with ortho substituents.

4 AND 5-Halo substituted 2-indanamine compounds

2-Indanamine compounds having 4 and 5-halo substituents are inhibitors of phenylethanolamine N-methyltransferase.