722456-31-7 Usage
Uses
Used in Pharmaceutical Industry:
1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide is used as a NAD(P)H oxidase (Nox) inhibitor for studying the role of Nox enzymes in various biological processes and diseases. It has been shown to abolish PDGF-mediated Nox activation and ROS production, as well as inhibit PMA-induced oxidative burst in HL-60 cells.
Used in Research Applications:
1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide is used as a research tool to investigate the importance of NOX-derived reactive oxygen species in cytoskeletal organization, proper localization of E-cadherin, and cell motility during zebrafish epiboly.
Used in Disease Model Studies:
In the field of disease model research, 1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide is used to study the function of Nox2 and Nox4 in lipopolysaccharide (LPS)-induced intestinal injury in high-fat diet (HFD) fed mice.
Used in Immunology Research:
1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide is utilized to reduce the reactive oxygen species level and study its influence on inhibiting the induction of trained innate immunity in monocytes, providing insights into the immune system's response to various stimuli.
Biochem/physiol Actions
VAS2870 is a cell-permeable and specific NADPH oxidase (NOX) inhibitor that effectively suppresses growth factor-mediated ROS liberation in VSMC.
References
1) Freyhaus et al. (2006), Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation; Cardiovasc. Res. 71 331
2) Stielow et al. (2006), Novel Nox inhibitor of oxLDL-induced reactive oxygen species formation in human endothelial cells; Biochem. Biophys. Res. Commun. 344 200
3) Sancho et al. (2011), The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells; Biochem. Pharmacol. 81 917
Check Digit Verification of cas no
The CAS Registry Mumber 722456-31-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,2,2,4,5 and 6 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 722456-31:
(8*7)+(7*2)+(6*2)+(5*4)+(4*5)+(3*6)+(2*3)+(1*1)=147
147 % 10 = 7
So 722456-31-7 is a valid CAS Registry Number.
722456-31-7Relevant articles and documents
Compounds containing a N-heteroaryl moiety linked to fused ring moieties for the inhibition of NAD(P)H oxidases and platelet activation
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Page/Page column 88-89, (2008/06/13)
The invention relates to compounds containing a N-heteroaryl moiety, which is linked via oxygen, sulfur or nitrogen, or via a methylene bridge and oxygen, sulfur or nitrogen to a fused ring moiety, in particular to the 1,2,3-triazolo[4,5-d]pyrimidine-7-yl radical. The invention also relates to a process for the preparation of said compounds and the use thereof in drugs for the treatment of NAD(P)H oxidases-related diseases and disorders and inhibition of platelet activation.
