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2-Phenylbenzoyl Methide is a complex organic compound with a unique structure formed by an aromatic acid and an aromatic hydrocarbon derivative. It is widely used in chemical and pharmaceutical industries due to its structural properties and high reactivity, making it a valuable intermediate in the production of various drugs and chemicals. However, safety precautions are required while handling this compound due to its potential reactivity and toxicity.

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  • 2142-66-7 Structure
  • Basic information

    1. Product Name: 2-PHENYLBENZOYL METHIDE
    2. Synonyms: O-PHENYLACETOPHENONE;2-PHENYLHYPNONE;2-PHENYLBENZOYL METHIDE;2-PHENYLACETYLBENZENE;2-ACETYLBIPHENYL;1-[1,1'-BIPHENYL]-2-YLETHANONE;AKOS BAR-1584;1-(2-phenylphenyl)ethanone
    3. CAS NO:2142-66-7
    4. Molecular Formula: C14H12O
    5. Molecular Weight: 195.24
    6. EINECS: 249-962-5
    7. Product Categories: N/A
    8. Mol File: 2142-66-7.mol
  • Chemical Properties

    1. Melting Point: 56-56.5 °C
    2. Boiling Point: 337.4 °C at 760 mmHg
    3. Flash Point: 146.1 °C
    4. Appearance: /
    5. Density: 1.053 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: Sealed in dry,Room Temperature
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-PHENYLBENZOYL METHIDE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-PHENYLBENZOYL METHIDE(2142-66-7)
    11. EPA Substance Registry System: 2-PHENYLBENZOYL METHIDE(2142-66-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 2142-66-7(Hazardous Substances Data)

2142-66-7 Usage

Uses

Used in Chemical Industry:
2-Phenylbenzoyl Methide is used as an intermediate for the synthesis of various chemicals, taking advantage of its distinctive compound structure and high reactivity in chemical reactions involving cross-coupling and electrophilic substitution.
Used in Pharmaceutical Industry:
2-Phenylbenzoyl Methide is used as an intermediate in the production of various drugs, leveraging its unique structural properties and reactivity to facilitate the synthesis of complex pharmaceutical compounds.

Check Digit Verification of cas no

The CAS Registry Mumber 2142-66-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,1,4 and 2 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 2142-66:
(6*2)+(5*1)+(4*4)+(3*2)+(2*6)+(1*6)=57
57 % 10 = 7
So 2142-66-7 is a valid CAS Registry Number.

2142-66-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Acetylbiphenyl

1.2 Other means of identification

Product number -
Other names 1-(1,1'-biphenyl-2-yl)ethanone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2142-66-7 SDS

2142-66-7Relevant articles and documents

Polyoxometalate-based N-Heterocyclic Carbene (NHC) complexes for palladium-mediated C-C coupling and chloroaryl dehalogenation catalysis

Berardi, Serena,Carraro, Mauro,Iglesias, Manuel,Sartorel, Andrea,Scorrano, Gianfranco,Albrecht, Martin,Bonchio, Marcella

supporting information; experimental part, p. 10662 - 10666 (2010/12/18)

Better together: A novel hybrid N-heterocyclic carbene (NHC) palladium complex, integrating a totally inorganic and polyanionic decatungstate unit, has been synthesized following a convergent strategy. The interplay of the Pd binding domains with the inorganic scaffold is instrumental in accessing multi-turnover catalysis in C-C crosscoupling and aromatic dehalogenation reactions under MW-assisted protocols (see scheme). (Figure Presented).

Pd(PPh3)4-PEG 400 catalyzed protocol for the atom-efficient stille cross-coupling reaction of organotin with aryl bromides

Zhou, Wen-Jun,Wang, Ke-Hu,Wang, Jin-Xian

supporting information; experimental part, p. 5599 - 5602 (2009/12/03)

(Chemical Equation Presented) Aryl bromides (4 equiv) were coupled efficiently with organotin (1 equiv) in an atom-efficient way using the tetra(triphenylphosphine)palladium/polyethylene glycol 400 (Pd(PPh 3)4/PEG 400) catalytic syst

Bis(tetrazolyl)benzenes as ligands in the Suzuki reaction: Promoters or inhibitors?

Burukin,Vasil'ev,Merkulova,Struchkova,Zlotin

, p. 118 - 122 (2007/10/03)

The Suzuki cross-coupling with phenylboronic acid in the presence of the Pd(OAc)2/K3PO4/DMF catalytic system was successful for aryl bromides and somewhat poorer for aryl chlorides. Addition of 1,3-bis(tetrazol-1-yl)benzene or its analogs lowered the yields of biaryls.

A catalytic and mechanistic investigation of a PCP pincer palladium complex in the Stille reaction

Olsson, Daniel,Nilsson, Patrik,El Masnaouy, Mostafa,Wendt, Ola F.

, p. 1924 - 1929 (2007/10/03)

In an improved procedure, the complex {2,6-bis[(diphenylphosphino)methyl] benzene}chloropalladium(II) (1) was synthesised as its THF adduct and the structure was determined by X-ray crystallography. The catalytic properties of the derivative {2,6-bis[(diphenylphosphino)methyl]benzene}(trmuoroacetato) palladium(II) (2) was investigated in the Stille reaction. Complex 2 proves to be an excellent catalyst for the C-C cross-coupling between trimethyl phenyl stannane and aryl bromides using a very low catalyst loading (0.1-0.0001%), giving high turnover numbers (TONs) up to 6.9 × 105. A kinetic investigation of the catalytic reaction suggests a heterogeneous colloidal palladium catalyst formed from the PCP Pd(II) pre-catalyst. The Royal Society of Chemistry 2005.

A Mild and Versatile Method for Palladium-Catalyzed Cross-Coupling of Aryl Halides in Water and Surfactants

Arcadi, Antonio,Cerichelli, Giorgio,Chiarini, Marco,Correa, Mariano,Zorzan, Daniel

, p. 4080 - 4086 (2007/10/03)

Various aqueous surfactants proved to be excellent media for carrying out palladium-catalyzed Suzuki-Miyaura cross-coupling reactions under mild conditions. The dehalogenation side reaction, which is usually a drawback with the aqueous protocol, was not observed. The concentration of the surfactant in water played a pivotal role for the reaction outcome. Smooth cross-coupling of iodoanisole and a variety of aryl bromides, including electron-rich derivatives, with aryl boronic acids occurred at room temperature in high yields either with [Pd(PPh3)4] or Pd/C as catalyst. The water-surfactant Pd/C system combines high activity under ambient conditions (air), easy separation and recyclability. Palladium acetate was found to be effective in cross-coupling of the less reactive aryl chlorides at 100 °C. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

Ligands for metals and improved metal-catalyzed processes based thereon

-

, (2008/06/13)

One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition metal-catalyzed reactions, including the range of suitable substrates, reaction conditions, and efficiency.

Intramolecular reactivity of arylcarbenes: Biphenyl-2-ylcarbenes

Dorra, Michael,Gomann, Klaus,Guth, Michael,Kirmse, Wolfgang

, p. 598 - 610 (2007/10/03)

Biphenyl-2-ylcarbenes, 2-ArC6H4CR, were generated photolytically and thermally from diazo precursors. Cyclization, leading to fluorenes, competes with capture of the carbenes by methanol but proceeds faster than intramolecular hydrogen shifts (with R = Me) and intermodular C - H insertion reactions (with R = H in cyclohexane). By comparison of product ratios with kinetic data for related carbenes from the literature, the cyclization rate is estimated as ca 1011 s-1. The intramolecular reactivity of biphenyl-2-ylcarbenes is not significantly attenuated by variation of R (R = H, Me, Ph). Very minor effects of triplet sensitization and methanol quenching indicate that fluorenes arise from spin-equilibrated biphenyl-2-ylcarbenes, presumably from the singlet state. When Ar = mesityl, the carbene predominantly inserts into C - H bonds of the 2′-methyl groups, giving rise to a dihydrophenanthrene. Formation of a fluorene derivative, by formal insertion into C - C bonds, occurs as a minor process. This unprecedented reaction points to intervention of an o-xylylene in which the methyl group migrates. Laser flash photolysis (LFP) of 2-PhC6H4CN2Ph generates a transient absorption which is due to the T0→Tn transition of 9-phenylfluorene rather than to the presumed o-xylylene. On LFP of 2-ArC6H4CN2Ph in trifluoroethanol-acetonitrile, protonation of the carbenes gives rise to carbocations, 2-ArC6H4CH+Ph. The transient absorption spectra of these cations are strongly influenced by twisting about the Ar - Ar bond (Ar = Ph 4.

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