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Cyclopenta[b]pyrrol-2(1H)-one, hexahydro-, (3aR,6aS)-rel- (9CI) is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 214263-63-5 Structure
  • Basic information

    1. Product Name: Cyclopenta[b]pyrrol-2(1H)-one, hexahydro-, (3aR,6aS)-rel- (9CI)
    2. Synonyms: Cyclopenta[b]pyrrol-2(1H)-one, hexahydro-, (3aR,6aS)-rel- (9CI);(3aR,6aS)-rel-hexahydro-Cyclopenta[b]pyrrol-2(1H)-one (Relative struc)
    3. CAS NO:214263-63-5
    4. Molecular Formula: C7H11NO
    5. Molecular Weight: 125.16834
    6. EINECS: N/A
    7. Product Categories: PYRROLIDINE
    8. Mol File: 214263-63-5.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Cyclopenta[b]pyrrol-2(1H)-one, hexahydro-, (3aR,6aS)-rel- (9CI)(CAS DataBase Reference)
    10. NIST Chemistry Reference: Cyclopenta[b]pyrrol-2(1H)-one, hexahydro-, (3aR,6aS)-rel- (9CI)(214263-63-5)
    11. EPA Substance Registry System: Cyclopenta[b]pyrrol-2(1H)-one, hexahydro-, (3aR,6aS)-rel- (9CI)(214263-63-5)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 214263-63-5(Hazardous Substances Data)

214263-63-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 214263-63-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,4,2,6 and 3 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 214263-63:
(8*2)+(7*1)+(6*4)+(5*2)+(4*6)+(3*3)+(2*6)+(1*3)=105
105 % 10 = 5
So 214263-63-5 is a valid CAS Registry Number.

214263-63-5Downstream Products

214263-63-5Relevant articles and documents

Synthesis of trans-fused [5,5] bicyclic lactones/lactams as templates for serine protease inhibition

Kelly, Henry A.,Bolton, Richard,Brown, Stuart A.,Coote, Steven J.,Dowle, Mike,Dyer, Ulrich,Finch, Harry,Golding, Doreen,Lowdon, Andrew,McLaren, Jessica,Montana, John G.,Owen, Martin R.,Pegg, Neil A.,Ross, Barry C.,Thomas, Rhian,Walker, Dawn A.

, p. 6979 - 6982 (1998)

Efficient routes have been developed for the synthesis of the trans- lactone 2 the trans-lactam 3 and their 3-substituted analogues based upon cyclisation strategies using Mukaiyama's reagent. 3β-Allyl, thiophenyl and propyl lactones 5 inhibit chymotrypsi

Highly Robust Iron Catalyst System for Intramolecular C(sp3)?H Amidation Leading to γ-Lactams

Kweon, Jeonguk,Chang, Sukbok

supporting information, p. 2909 - 2914 (2020/12/11)

Disclosed here is the use of an iron catalyst system for an intramolecular C?H amidation toward γ-lactam synthesis from dioxazolone precursors. (Phthalocyanine)FeIIICl was found to catalyze this cyclization with extremely high turnover numbers of up to 47 000 under mild and aerobic conditions. On the basis of experimental and computational mechanistic studies, the reaction is suggested to proceed by a stepwise radical pathway involving fast hydrogen atom abstraction followed by radical rebound. A plausible origin for the high turnover numbers along with air-compatibility is also rationalized.

Synthesis of Lactams via Ir-Catalyzed C-H Amidation Involving Ir-Nitrene Intermediates

Li, Xiaoxun,Liu, Jitian,Tang, Weiping,Wang, Shuojin,Ye, Wenjing,Zheng, Junrong

, (2020/03/19)

x-membered lactams were synthesized via either an amidation of sp3 C-H bonds or an electrophilic substitution of arenes via Ir-nitrene intermediates. With the employment of a readily available iridium catalyst in dichloromethane or hexafluoro-2-propanol, a wide range of lactams were synthesized in good to excellent yields with high selectivity.

Synthetic Utility of N-Benzoyloxyamides as an Alternative Precursor of Acylnitrenoids for γ-Lactam Formation

Huh, Soohee,Hong, Seung Youn,Chang, Sukbok

, p. 2808 - 2812 (2019/04/17)

Described herein is the development of a new entry of acylnitrenoid precursors for γ-lactam synthesis via an intramolecular C-H amidation reaction. Upon Ir catalysis, N-benzoyloxyamides serve as efficient substrates to afford 5-membered amides. Mechanistic studies revealed that the generation of a putative Ir-carbonylnitrenoid via N-O bond cleavage is facilitated by the chelation of countercations. This protocol offers a convenient and step-economic route to γ-lactams starting from the corresponding carboxylic acids.

Selective formation of γ-lactams via C-H amidation enabled by tailored iridium catalysts

Hong, Seung Youn,Park, Yoonsu,Hwang, Yeongyu,Kim, Yeong Bum,Baik, Mu-Hyun,Chang, Sukbok

, p. 1016 - 1021 (2018/03/09)

Intramolecular insertion of met al nitrenes into carbon-hydrogen bonds to form γ-lactam rings has traditionally been hindered by competing isocyanate formation. We report the application of theory and mechanism studies to optimize a class of pentamethylcyclopentadienyl iridium(III) catalysts for suppression of this competing pathway. Modulation of the stereoelectronic properties of the auxiliary bidentate ligands to be more electron-donating was suggested by density functional theory calculations to lower the C-H insertion barrier favoring the desired reaction. These catalysts transform a wide range of 1,4,2-dioxazol-5-ones, carbonylnitrene precursors easily accessible from carboxylic acids, into the corresponding γ-lactams via sp3 and sp2 C-H amidation with exceptional selectivity. The power of this method was further demonstrated by the successful late-stage functionalization of amino acid derivatives and other bioactive molecules.

Arylethynyl derivatives

-

, (2015/05/26)

The present invention relates to ethynyl derivatives of formula I wherein R1 is phenyl, which is optionally substituted by 1-2 halogen atoms; selected from fluorine or chlorine;or to a pharmaceutically acceptable acid addition salt in enantiome

ARYLETHYNYL DERIVATIVES

-

, (2014/02/15)

The present invention relates to ethynyl derivatives of formula (I) wherein R1 is phenyl, which is optionally substituted by 1-2 halogen atoms; selected from fluorine or chlorine; or to a pharmaceutically acceptable acid addition salt in enanti

Design and synthesis of a candidate α-human thrombin irreversible inhibitor containing a hydrophobic carborane pharmacophore

Page, Michael F. Z.,Jalisatgi, Satish S.,Maderna, Andreas,Hawthorne, M. Frederick

, p. 555 - 563 (2008/12/21)

α-Human thrombin is a potent platelet agonist involved in the blood coagulation cascade and is an attractive target for an anticoagulant agent due to its involvement in several debilitating diseases. In this contribution we present attempts to develop a new architecture for size-selective serine protease inhibitors that utilize a fully methylated icosahedral p-carborane as a dominating hydrophobic pharmacophore. Using a computational docking program, flexX, a carborane-containing inhibitor was designed and synthesized. Computationally, this compound displayed the ability to provide ligand-protein binding interactions throughout the thrombin's main active site (S1-S3), while positioning an acylating group for facile irreversible attack at the Ser 195 hydroxyl group. Georg Thieme Verlag Stuttgart.

Asymmetric intramolecular crossed-benzoin reactions by N-heterocyclic carbene catalysis

Enders, Dieter,Niemeier, Oliver,Balensiefer, Tim

, p. 1463 - 1467 (2007/10/03)

(Chemical Equation Presented) Getting cross: Excellent asymmetric inductions and very good yields are achieved in the generation of a quaternary stereocenter in α-hydroxy-substituted tetralones by using chiral N-heterocyclic carbene catalysts in an enantioselective intramolecular crossed-benzoin reaction. The synthesis of the corresponding α-hydroxyindanones with good ee values is also possible by this route.

Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase

Shankaran,Donnelly, Karla L.,Shah, Shrenik K.,Guthikonda, Ravindra N.,MacCoss, Malcolm,Humes, John L.,Pacholok, Stephen G.,Grant, Stephan K.,Kelly,Wong

, p. 4539 - 4544 (2007/10/03)

Syntheses and evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2- imines as inhibitors of nitric oxide synthase (NOS) are discussed. An extensive SAR was established for pyrrolidin-2-imines class of compounds. The amidines came out as the most potent inhibitors in addition to displaying selectivity.

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