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tert-Butyl-[1-(2-iodo-1-methyl-ethyl)-7a-methyl-octahydro-inden-4-yloxy]-dimethyl-silane is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • tert-Butyl-[1-(2-iodo-1-methyl-ethyl)-7a-methyl-octahydro-inden-4-yloxy]-dimethyl-silane

    Cas No: 214351-86-7

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  • ENDOTHERM GmbH
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  • tert-Butyl-[1-(2-iodo-1-methyl-ethyl)-7a-methyl-octahydro-inden-4-yloxy]-dimethyl-silane

    Cas No: 214351-86-7

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  • 214351-86-7 Structure
  • Basic information

    1. Product Name: tert-Butyl-[1-(2-iodo-1-methyl-ethyl)-7a-methyl-octahydro-inden-4-yloxy]-dimethyl-silane
    2. Synonyms: tert-Butyl-[1-(2-iodo-1-methyl-ethyl)-7a-methyl-octahydro-inden-4-yloxy]-dimethyl-silane
    3. CAS NO:214351-86-7
    4. Molecular Formula: C19H37IOSi
    5. Molecular Weight: 436.49
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 214351-86-7.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 392.6°C at 760 mmHg
    3. Flash Point: 191.2°C
    4. Appearance: /
    5. Density: 1.18g/cm3
    6. Vapor Pressure: 5.12E-06mmHg at 25°C
    7. Refractive Index: 1.504
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: tert-Butyl-[1-(2-iodo-1-methyl-ethyl)-7a-methyl-octahydro-inden-4-yloxy]-dimethyl-silane(CAS DataBase Reference)
    11. NIST Chemistry Reference: tert-Butyl-[1-(2-iodo-1-methyl-ethyl)-7a-methyl-octahydro-inden-4-yloxy]-dimethyl-silane(214351-86-7)
    12. EPA Substance Registry System: tert-Butyl-[1-(2-iodo-1-methyl-ethyl)-7a-methyl-octahydro-inden-4-yloxy]-dimethyl-silane(214351-86-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 214351-86-7(Hazardous Substances Data)

214351-86-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 214351-86-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,4,3,5 and 1 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 214351-86:
(8*2)+(7*1)+(6*4)+(5*3)+(4*5)+(3*1)+(2*8)+(1*6)=107
107 % 10 = 7
So 214351-86-7 is a valid CAS Registry Number.
InChI:InChI=1/C19H37IOSi/c1-14(13-20)15-10-11-16-17(9-8-12-19(15,16)5)21-22(6,7)18(2,3)4/h14-17H,8-13H2,1-7H3

214351-86-7Relevant articles and documents

Stereoselective Palladium-Catalyzed Approach to Vitamin D3 Derivatives in Protic Medium

Carballa, Diego,Sigüeiro, Rita,Rodríguez-Docampo, Zaida,Zacconi, Flavia,Maestro, Miguel A.,Mouri?o, Antonio

supporting information, p. 3314 - 3320 (2018/02/12)

We describe an efficient convergent synthesis of vitamin D3 metabolites and analogues. The synthetic strategy relies on a tandem Pd-catalyzed A-ring closure and Suzuki–Miyaura coupling to the CD-side chain component to set directly the vitamin D triene system under protic conditions. This strategy enables rapid access to vitamin D3 and 3-epi-vitamin D3 metabolites and analogues modified at the side chain for biological evaluation and structural and metabolic studies.

26- and 27-Methyl groups of 2-substituted, 19-nor-1α,25- dihydroxylated vitamin D compounds are essential for calcium mobilization in vivo

Grzywacz, Pawel,Plum, Lori A.,Clagett-Dame, Margaret,Deluca, Hector F.

, p. 9 - 16 (2013/05/09)

Twelve new analogs of 19-nor-1α,25-dihydroxyvitamin D3 6-17, were prepared by a multi-step procedure from known alcohols 18 and 19. We have examined the influence of removing two methyl groups located at C-25, as well as the 25-hydroxy group, o

Synthesis of 20-epi-eldecalcitol [20-epi-1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3: 20-epi-ED-71]

Yoshino, Madoka,Eto, Kohei,Takahashi, Keisuke,Ishihara, Jun,Hatakeyama, Susumi,Ono, Yoshiyuki,Saito, Hitoshi,Kubodera, Noboru

experimental part, p. 381 - 394 (2010/09/05)

A convergent synthesis of biologically interesting 20-epi-eldecalcitol which possesses an inverted C-21 methyl substituent at the 20-position of the side chain of 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (eldecalcitol) is described.

Synthesis and preliminary biological evaluation of 20-epi-eldecalcitol [20-epi-1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3: 20-epi-ED-71]

Hatakeyama, Susumi,Yoshino, Madoka,Eto, Kohei,Takahashi, Keisuke,Ishihara, Jun,Ono, Yoshiyuki,Saito, Hitoshi,Kubodera, Noboru

scheme or table, p. 25 - 28 (2011/12/01)

Eldecalcitol [1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3, developing code: ED-71] is an analog of active vitamin D3, 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3] that possesses a hydroxypropoxy substituent at the 2β-position of 1,25(OH)2D3. Eldecalcitol has potent biological effects on bone and is now in preparation for approval as a promising medicine for the treatment of osteoporosis in Japan. To explore chemical structure-biological activity relationships between eldecalcitol and related analogs, we have already synthesized 1-epi-eldecalcitol, 3-epi-eldecalcitol, and 1,3-diepi-eldecalcitol with inherent biological interests of each targeted analog and evaluated their biological responses. It has been reported that 20-epi-1,25(OH)2D3, a diastereomer of 1,25(OH)2D3 that possesses an inverted methyl substituent at the 20-position of the side chain, shows remarkably enhanced biological activities compared to parental compound, 1,25(OH)2D3. As a continuation of our modification studies on eldecalcitol, we took great interest in 20-epi-eldecalcitol and its biological responses. In this paper, the synthesis of 20-epi-eldecalcitol by the Trost coupling reaction between the A-ring fragment and the C/D-ring fragment as well as in vitro preliminary biological evaluation of 20-epi-eldecalcitol are described. In the induction of human myeloid leukemia cell (HL-60) differentiation, inhibition of the human histiocytic lymphoma cell (U937) proliferation, and increase in osteocalcin concentration in the human osteosarcoma cell (MG-63), 20-epi-eldecalcitol showed significantly enhanced activity compared to eldecalcitol.

2alpha-Methyl and 2beta-methyl analogs of 19,26,27-trinor-(20S)-1alpha-hydroxyvitamin D3 and their uses

-

Page/Page column 4-5, (2010/11/08)

This invention discloses 2α-methyl and 2β-methyl analogs of 19,26,27-trinor-(20S) -1α-hydroxyvitamin D3 and pharmaceutical uses therefor. These compounds exhibit pronounced activity in arresting the proliferation of undifferentiated cells and i

2-METHYLENE-19,26,27-TRINOR-(20S)-1α-ALPHA-HYDROXYVITAMIN D3 AND ITS USES

-

Page/Page column 11-12, (2010/11/08)

This invention discloses 2-methylene-19,26,27-trinor-(20S)-vitamin D analogs, and specifically 2-methylene-19,26,27-trinor-(20S)-lα-hydroxyvitamirt D3 and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the

19,26,27-TRINOR-1α,25-DIHYDROXYVITAMIN D3 COMPOUNDS

-

Page/Page column 22-23, (2010/11/24)

Compounds of formula (1) are provided where X1, X2, and X3 are independently selected from H or hydroxy protecting groups, and R1 and R2 have the definitions provided herein. Such compounds may be used in preparing pharmaceutical compositions and are useful in treating a variety of biological conditions.

Vitamin D analogs for obesity prevention and treatment

-

, (2008/06/13)

Methods for treating and preventing obesity, inhibiting adipocyte differentiation, inhibiting increased SCD-1 gene transcription, and/or reducing body fat in a subject include administering at least one analog of 1α,25-dihydroxyvitamin D3 or 1α

Efficient synthesis and biological evaluation of all A-ring diastereomers of 1α,25-dihydroxyvitamin D3 and its 20-epimer

Fujishima, Toshie,Konno, Katsuhiro,Nakagawa, Kimie,Kurobe, Mayuko,Okano, Toshio,Takayama, Hiroaki

, p. 123 - 134 (2007/10/03)

An improved synthesis of the diastereomers of 1α,25-dihydroxyvitamin D3 (1) was accomplished utilizing our practical route to the A-ring synthon. We applied this procedure to synthesize for the first time all possible A- ring diastereomers of 20-epi-1α,25-dihydroxyvitamin D3 (2). Ten-step conversion of 1-(4-methoxyphenoxy)but-3-ene (6), including enantiomeric introduction of the C-3 hydroxyl group to the olefin by the Sharpless asymmetric dihydroxylation, provided all four possible stereoisomers of A- ring enynes (3), i.e., (3R,5R)-, (3R,5S)-, (3S,5R)- and (3S,5S)-bis[(tert- butyldimethylsilyl)oxy]oct-1-en-7-yne, in good overall yield. Palladium- catalyzed cross-coupling of the A-ring synthon with the 20-epi CD-ring portion (5), (E)-(20S)-de-A,B-8-(bromomethylene)cholestan-25-ol, followed by deprotection, afforded the requisite diastereomers of 20-epi-1α,25- dihydroxyvitamin D3 (2). The biological profiles of the synthesized stereoisomers were assessed in terms of affinities for vitamin D receptor (VDR) and vitamin D binding protein (DBP), HL-60 cell differentiation- inducing activity and in vivo calcium-regulating potency in comparison with the natural hormone. (C) 2000 Elsevier Science Ltd.

Synthesis and biological activity of 2-methyl-20-epi analogues of 1α,25-dihydroxyvitamin D3

Fujishima, Toshie,Liu, Zhaopeng,Miura, Daishiro,Chokki, Manabu,Ishizuka, Seiichi,Konno, Katsuhiro,Takayama, Hiroaki

, p. 2145 - 2148 (2007/10/03)

Synthesis and biological evaluation of all eight possible A-ring diastereomers of 2-methyl-20-epi-1,25-dihydroxyvitamin D3 are described. Among the analogues synthesized, 2α-methyl-20-epi-1α,25-dihydroxyvitamin D3 exhibited exceptionally high potency. The double modification of 2- methyl substitution and 20-epimerization yielded analogues with unique activity profiles.

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