Novel compounds useful for bradykinin B1 receptor antagonism
Disclosed are compounds that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor.
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(2010/11/25)
Synthesis of racemic nitramine, isonitramine and sibirine
Condensation of enol ether 6 with methyl vinyl ketone led easily to ketoaldehyde 7 whose cyclisation afforded the azaspiranic enone 8, a key intermediate for the synthesis of the title alkaloids.
Deyine, Abdallah,Poirier, Jean-Marie,Duhamel, Lucette,Duhamel, Pierre
PCT No. PCT/EP98/02136 Sec. 371 Date Oct. 4, 1999 Sec. 102(e) Date Oct. 4, 1999 PCT Filed Apr. 2, 1998 PCT Pub. No. WO98/45297 PCT Pub. Date Oct. 15, 1998The present invention concerns the compounds of formula the N-oxides, the pharmaceutically acceptable
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(2008/06/13)
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