215033-43-5Relevant articles and documents
7-Endo selective aryl radical cyclization onto enamides leading to 3-benzazepines: Concise construction of a cephalotaxine skeleton
Taniguchi, Tsuyoshi,Ishita, Atsuko,Uchiyama, Masahiko,Tamura, Osamu,Muraoka, Osamu,Tanabe, Genzoh,Ishibashi, Hiroyuki
, p. 1922 - 1925 (2007/10/03)
(Chemical Equation Presented) Bu3SnH-mediated radical cyclizations of 2-(2-bromophenyl)-N-ethenylacetamide gave 6-exo cyclization product 15 as the major product, whereas N-[2-(2-bromophenyl)ethyl]-N- ethenylamides gave almost exclusively 7-end
Thermogenic composition and benzazepine thermogenics
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, (2008/06/13)
The object of the present invention is to provide a prophylactic and/or therapeutic drug for obesity and obesity-associated diseasestor diabetes with a reduced risk for central side effects and high universality in usage. Another object of the present invention is to provide a pharmaceutical composition comprising a compound of the following formula: wherein Ar represents phenyl which may be substituted and/or condensed; n represents an integer of 1 to 10; R represents hydrogen or a hydrocarbon group which may be substituted, which may not be the same in its n occurrences; R may be bound to either Ar or a substituent for Ar; Y represents an amino group which may be subsituted or a nitrogen-containing saturated heterocyclic group which may be substituted, or a salt thereof, which can be used for a thermogenic agent, an antiobesity agent, a lipolytic agent, or a prophylactic and/or treating drug for obesity-associated diseases.
Preventives and remedies for central nervous system diseases
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, (2008/06/13)
A prophylactic or therapeutic agent for central nervous system diseases based on amyloid β40 secretion inhibitory activity of a compound having urotensin II receptor antagonistic activity or a salt thereof.
GPR14 ANTAGONIST
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, (2008/06/13)
A novel GPR14 antagonist. The GPR14 antagonist comprises a compound represented by the formula (I) or a salt thereof wherein Ar represents optionally substituted aryl; X represents a spacer; n is an integer of 1 to 10; R represents an optionally substitut
A synthesis of 2,3,4,5-tetrahydro-1H-3-benzazepines via Pummerer-type cyclization of N-(2-arylethyl)-N-(2-Phenylsulfinylethyl)formamides
Toda, Jun,Ichikawa, Tsuyoshi,Saitoh, Toshiaki,Horiguchi, Yoshie,Sano, Takehiro
, p. 2009 - 2018 (2007/10/03)
A construction of 2,3,4,5-tetrahydro-1H-3-benzazepine ring system (7) was achieved via Pummerer-type cyclization of N-(2-arylethyl)-N-2-(phenylsulfinylethyl)formamides (6). This route produced the benzazepines (10) and (11) in six steps starting from readily available 2-arylethylamines (2) and 2-chloroethyl phenyl sulfide.