21573-29-5

Basic information

• Product Name: 4-(acetylamino)-2-nitrobenzoic acid
• Synonyms: 4-Acetamido-2-nitrobenzoic acid; benzoic acid, 4-(acetylamino)-2-nitro-
• CAS NO: 21573-29-5
• Molecular Formula: C₉H₈N₂O₅
• Molecular Weight: 224.1702
• Mol File: 21573-29-5.mol

Chemical Properties

• Boiling Point: 488.2°C at 760 mmHg
• Flash Point: 249°C
• Density: 1.526g/cm³
• Vapor Pressure: 2.41E-10mmHg at 25°C
• Refractive Index: 1.656
• CAS DataBase Reference: 4-(acetylamino)-2-nitrobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(acetylamino)-2-nitrobenzoic acid(21573-29-5)
• EPA Substance Registry System: 4-(acetylamino)-2-nitrobenzoic acid(21573-29-5)

Safety Data

• Hazardous Substances Data: 21573-29-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
4-(acetylamino)-2-nitrobenzoic acid is used as a pharmaceutical candidate for its potential anti-inflammatory and analgesic properties. It is a promising candidate for the development of new therapeutic drugs.
Used in Organic Synthesis:
4-(acetylamino)-2-nitrobenzoic acid is used as a key intermediate in the synthesis of various organic compounds.
Used in Corrosion Inhibition:
4-(acetylamino)-2-nitrobenzoic acid is used as a corrosion inhibitor to protect metal surfaces from corrosion.
Used in Dye and Pigment Production:
4-(acetylamino)-2-nitrobenzoic acid is used in the production of dyes and pigments due to its chemical properties.

Upstream product

• 2719-14-4 4-acetylamino-2-nitrotoluene 
• 7487-88-9 magnesium sulfate 
• 119-32-4 4-Methyl-3-nitroanilin 

Downstream Products

• 610-36-6 4-amino-2-nitrobenzoic acid 
• 43134-76-5 1-amino-3-acetylamino-6-carboxy-benzene 
• 99-09-2 3-nitro-aniline 
• 84228-46-6 4-amino-2-nitrobenzoic acid ethyl ester 
• 1606159-07-2 C₁₁H₁₁N₃O₂S 
• 1606159-31-2 C₂₁H₂₂N₄O₃ 

Relevant articles and documents

Functionalization of quinazolin-4-ones part 1: Synthesis of novel 7-substituted-2-thioxo quinazolin-4-ones from 4-substituted-2-aminobenzoic acids and PPh3(SCN)2

4-(Nitro, amino, acetylamino)-2-aminobenzoic acid were allowed to react with PPh3(SCN)2 and gave the crossholding 7-nitro, 7-acetylamino- and 7-amino-2-thioxo quinazolin-4-ones respectively. The nature of the substituent at position 4 of the 2-aminobenzoic acids has significant influence on the outcome of the cyclisation reaction with PPh 3(SCN)2. Similarly, the nature of the substituent at position 7 of the 2-substituted quinazolin-4-ones significantly affected the ease with which alkylation reactions could be performed. The alkylation selectivity of the 7- substiuted-2-thioxo quinazolin-4-ones was found to depend on the nature of the alkyl halide and the nature of the substituent at position 2.

Optical element and compounds used in its manufacture

An optical frequency conversion element has a wave-guiding layer which consists of a χ(2) -active ferroelectric liquid crystal. The monomeric or polymeric liquid crystal material has a periodic structure which permits the so-called quasi phase matching of a guided laser beam. The period length of the structure is equal to twice the coherence length lc =?/Δβ of the material, whereby Δβ=βo (2ω)-2βo (ω), with ω=angular frequency of the fundamental wave, 0=zero-order mode and β=propagation constant of the mode.

Benzyl-piperidine derivatives

Benzly-piperidine derivatives of formula I and their pharmaceutically acceptable salts are used in the control of psychotic disorders which are caused by damage to the dopamine system, especially schizophrenia. STR1 A is STR2 B is STR3 R 1, R 2 and R 3 are independently hydrogen, amino, nitro, halogen, lower-alkly or lower-alkoxy. R 4, R 5 and R 6 are independently hydrogen, nitro, halogen, lower-alkyl, lower-alkoxy, cyano, trifluoromethyl, amino, lower-alkylamino or di-lower-alkylamino. R 7, R 2 and R 9 are independently hydrogen, amino or nitro.

Retinoid-like compounds

The present invention relates to a compound of formula I STR1 or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, in whichX is --O--CO--, --NH--CO--, --CS--NH--, --CO--O--, --CO--NH--, --COS--, --SCO--, --SCH 2 --, --CH 2 --CH 2 --, --C C--, --CH 2 --NH--, --COCH 2 --, --NHCS--, --CH 2 S--, --CH 2 O--, --OCH 2 --, --NHCH 2 -- or --CR 5 CR 6 --;R m and R k are independently hydrogen, halogen, C 1-6 alkyl, hydroxy, C 1-6 alkyloxy or nitro;n is zero or one;R 4 is --(CH 2) t --Y, C 1-6 alkyl, or C 3-6 cycloalkyl;R 1 is --CO 2 Z, C 1-6 alkyl, CH 2 OH, --CONHR y, or CHO;R 2 and R 3 are independently hydrogen or C 1-6 alkyl;R a and R b are independently hydrogen or C 1-6 alkyl; but when n is one, R a and R b together can form a radical of the formula STR2 Y is naphthyl or phenyl, both radicals can be optionally substituted with one to three same or different C 1-6 alkyl or halogen;Z is hydrogen or C 1-6 alkyl;R 5, R 6 and R y are independently hydrogen or C 1-6 alkyl; andt is zero to six.

Retinoid-like compounds

The present invention relates to a compound of formula STR1 or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, in which X is --O--CO--, --NH--CO--, --CS--NH--, --CO--O--, --CO--NH--, --COS--, --SCO--, --SCH2 --, --CH2 --CH2 --, --C C--, --CH2 --NH--, --COCH2 --, --NHCS--, --CH2 S--, --CH2 O--, --OCH2 --, --NHCH2 -- or --CR5 =CR6 --; Rm and Rk are independently hydrogen, halogen, C1-6 alkyl, hydroxy, C1-6 alkyloxy or nitro; n is zero or one; R4 is --(CH2)t --Y, C1-6 alkyl, or C3-6 cycloalkyl; R1 is --CO2 Z, C1-6 alkyl, CH2 OH, --CONHRy, or CHO; R2 and R3 are independently hydrogen or C1-6 alkyl; Ra and Rb are independently hydrogen or C1-6 alkyl; but when n is one, Ra and Rb together can form a radical of the formula STR2 Y is naphthyl or phenyl, both radicals can be optionally substituted with one to three same or different C1-6 alkyl or halogen; Z is hydrogen or C1-6 alkyl; R5, R6 and Ry are independently hydrogen or C1-6 alkyl; and t is zero to six.