610-36-6

Basic information

• Product Name: 4-Amino-2-nitrobenzoic acid
• Synonyms: 4-AMINO-2-NITROBENZOIC ACID;4-azanyl-2-nitro-benzoic acid
• CAS NO: 610-36-6
• Molecular Formula: C₇H₆N₂O₄
• Molecular Weight: 182.13
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 610-36-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 239 °C
• Boiling Point: 440.9 °C at 760 mmHg
• Flash Point: 220.4 °C
• Appearance: /
• Density: 1.568 g/cm³
• Vapor Pressure: 1.5E-08mmHg at 25°C
• Refractive Index: 1.681
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.84±0.25(Predicted)
• CAS DataBase Reference: 4-Amino-2-nitrobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-2-nitrobenzoic acid(610-36-6)
• EPA Substance Registry System: 4-Amino-2-nitrobenzoic acid(610-36-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 610-36-6(Hazardous Substances Data)

Usage

General Description

4-Amino-2-nitrobenzoic acid is a chemical compound with the molecular formula C7H6N2O4. It is a derivative of benzoic acid and is commonly used as an intermediate in the synthesis of pharmaceuticals and dyes. 4-Amino-2-nitrobenzoic acid is characterized by its yellow crystalline appearance and is sparingly soluble in water. 4-Amino-2-nitrobenzoic acid is known for its use in organic chemistry research as a reagent and building block for the production of various organic compounds. It is also used as a raw material in the manufacturing of drugs and other fine chemicals.

InChI:InChI=1/C7H6N2O4/c8-4-1-2-5(7(10)11)6(3-4)9(12)13/h1-3H,8H2,(H,10,11)

Upstream product

• 7647-01-0 hydrogenchloride 
• 121-14-2 2,4-dinitrotoluene 
• 28144-70-9 anthranilic acid amide 
• 610-30-0 2,4-dinitrobenzoic acid 
• 342045-62-9 4-acetylamino-6-nitro-isophthalic acid 
• 7664-93-9 sulfuric acid 
• 84228-46-6 4-amino-2-nitrobenzoic acid ethyl ester 
• 21573-29-5 4-acetylamino-2-nitrobenzoic acid 
• 64-17-5 ethanol 
• 7803-57-8 hydrazine hydrate 
• 2719-14-4 4-acetylamino-2-nitrotoluene 

Downstream Products

• 74230-08-3 4-hydroxy-2-nitrobenzoic acid 
• 84228-46-6 4-amino-2-nitrobenzoic acid ethyl ester 
• 99277-71-1 4-bromo-2-nitrobenzoic acid 
• 162046-38-0 1-tert-butyloxycarbonyl-4-trimethylstannyl-1,2,5,6-tetrahydropyridine 
• 171116-84-0 N-<2-(dimethylamino)ethyl>4-(2-nitrobenzamido)2-nitrobenzamide 
• 171116-85-1 4-nitrophenol 4-(2-nitrobenzamido)2-nitrobenzoate 
• 171116-86-2 1,11-bis<4-(2-nitrobenzamido)-2-nitrophenyl>-1,11-dioxo-6-methyl-2,6,10-triazaundecane 
• 1164350-77-9 2-nitro-4-((R)-2-phenoxypropionylamino)benzoic acid 
• 1072161-35-3 N₂-(N,N-dimethylaminomethylene)-2'-nitrofolic acid di-tert-butyl ester 
• 1072161-26-2 di-tert-butyl N-[4-(tert-butoxycarbonylamino)-2-nitrobenzoyl]-L-glutamate 
• 1072161-36-4 dimethyl N-[4-(tert-butoxycarbonylamino)-2-nitrobenzoyl]-L-glutamate 
• 1072161-28-4 N-(4-amino-2-nitrobenzoyl)-L-glutamic acid trifluoroacetate 
• 1072161-29-5 2'-nitrofolic acid 
• 1072161-30-8 2'-nitrofolic acid dimethyl ester 

Relevant articles and documents

The detection of glycine from the treatment of glyoxylic acid with iron(II) sulfate and ammonia in water

A glycine/(NH4)2SO4 mixture was isolated by treatment of glyoxylic acid with FeSO4 and aqNH3 in H2O. The yields of glycine were estimated by 1H NMR. Pyruvic acid was not reduced to alanine under these conditions. This method for forming glycine might have occurred prebiotically alongside the Urey-Miller arc discharge method for making amino acids because glyoxylic acid is formed by arc discharge through a N2/CO2 atmosphere and both NH3 and Fe(II) occurred in the earth's early oceans. The carboxylic acid directs the reduction of 2,4-dinitrobenzoic acid to give 2-amino-4-nitrobenzoic acid.

Optical element and compounds used in its manufacture

An optical frequency conversion element has a wave-guiding layer which consists of a χ(2) -active ferroelectric liquid crystal. The monomeric or polymeric liquid crystal material has a periodic structure which permits the so-called quasi phase matching of a guided laser beam. The period length of the structure is equal to twice the coherence length lc =?/Δβ of the material, whereby Δβ=βo (2ω)-2βo (ω), with ω=angular frequency of the fundamental wave, 0=zero-order mode and β=propagation constant of the mode.

Synthesis of reference substances for highly polar metabolites of nitroaromatic compounds

Transformation processes of nitroaromatic compounds (NAC) lead to polar and highly hydrophilic metabolites. For the unequivocal identification of proposed metabolites reference substances are needed. Since most of them are not commercially available, their synthesis was done in our group. In many cases no satisfying synthesis schemes were found in the literature. In this communication, we therefore describe the preparation, structural elucidation and separation of 17 compounds. Many of the newly synthesized analytes were found in various water samples from a former ammunition plant.