- Novel synthesized azo-benzylidene-thiourea as dual naked-eye chemosensor for selective detection of Hg2+ and CNˉ ions
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Seven novel chemosensors contain azo chromophore and phenylthiourea, were synthesized and applied as colorimetric probes in aqueous solutions of dimethyl sulfoxide. The anion recognition studies exhibited that the synthesized azo dye derivatives act as a
- Hosseinjani-Pirdehi, Hamide,Mahmoodi, Nosrat O.,Pasandideh Nadamani, Meysam,Taheri, Amir
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Read Online
- Clicking thiourea into a salen scaffold: Structures and cytotoxicity of cobalt(II) and nickel(II) complexes
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A thiourea moiety has been introduced into the known salen-type ligand scaffold to give a new unsymmetric ligand (L) by using a simple CLICK chemistry. The cobalt(II) and nickel(II) complexes of this ligand were prepared by a one-pot procedure and structu
- Zhang, Guoqi,Ta, Christine,Cheng, Shu-Yuan,Golen, James A.,Rheingold, Arnold L.
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- Potassium Periodate Mediated Oxidative Cyclodesulfurization toward Benzofused Nitrogen Heterocycles
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A convenient oxidative cyclodesulfurization method toward the synthesis of benzofused nitrogen heterocycles using inexpensive and readily available potassium periodate as an oxidant was developed. Upon treating isothiocyanates with ortho -substituted anilines bearing N, N -, N, O -, and N, S -bis-nucleophiles, followed by an intramolecular cyclization of the in situ generated monothioureas, substituted 2-aminobenzazole series were rapidly accessible in good to excellent yields. The protocol can accommodate various substituents on both substrates while allowing more efficient, greener, and operational simpler process relative to other oxidative coupling reactions. Tetracyclic quinazolinone derivatives were also afforded in high yields in a single preparative step and chromatography-free.
- Duangkamol, Chuthamat,Pattarawarapan, Mookda,Phakhodee, Wong
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p. 1981 - 1990
(2020/07/03)
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- Ultrasound-assisted synthesis of substituted 2-aminobenzimidazoles, 2-aminobenzoxazoles, and related heterocycles
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A sonochemical method for the synthesis of 2-aminobenzimidazoles and 2-aminobenzoxazoles, as well as chiral aminooxazolines and a chiral substituted quinazolin-5-one is reported. Using the Ph3P–I2system in the presence of triethylami
- Phakhodee, Wong,Duangkamol, Chuthamat,Wiriya, Nittaya,Pattarawarapan, Mookda
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supporting information
p. 5290 - 5293
(2016/11/11)
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- Click mechanochemistry: Quantitative synthesis of "ready to use" chiral organocatalysts by efficient two-fold thiourea coupling to vicinal diamines
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Mechanochemical methods of neat grinding and liquid-assisted grinding have been applied to the synthesis of mono- and bis(thiourea)s by using the click coupling of aromatic and aliphatic diamines with aromatic isothiocyanates. The ability to modify the re
- Strukil, Vjekoslav,Igrc, Marina D.,Eckert-Maksic, Mirjana,Friscic, Tomislav
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supporting information; experimental part
p. 8464 - 8473
(2012/09/05)
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- Desymmetrisation of aromatic diamines and synthesis of non-symmetrical thiourea derivatives by click-mechanochemistry
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ortho- and para-Phenylenediamines were desymmetrised and quantitatively transformed into mono- and bis-(thio)ureas or mixed thiourea-ureas through a one-pot mechanochemical click reaction sequence; mechanochemical desymmetrisation proceeds quantitatively
- Strukil, Vjekoslav,Margetic, Davor,Igrc, Marina D.,Eckert-Maksic, Mirjana,Friscic, Tomislav
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supporting information
p. 9705 - 9707
(2012/10/29)
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- Synthesis, antibacterial activities and molecular docking studies of Schiff bases derived from N-(2/4-benzaldehyde-amino) phenyl-N′-phenyl-thiourea
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A series of novel Schiff base derivatives have been designed and synthesized, and their biological activities were also evaluated as potential inhibitors of FabH. These compounds were assayed for antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus aureus. Compounds with potent antibacterial activities were tested for their E. coli FabH inhibitory activity. Compound 3v showed the most potent antibacterial activity with MIC of 1.56-6.25 μg/mL against the tested bacterial strains and exhibited the most potent E. coli FabH inhibitory activity with IC50 of 4.3 μM. Docking simulation was performed to position compound 3v into the E. coli FabH active site to determine the probable binding conformation.
- Zhang, Hong-Jia,Qin, Xuan,Liu, Kai,Zhu, Di-Di,Wang, Xiao-Ming,Zhu, Hai-Liang
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experimental part
p. 5708 - 5715
(2011/10/19)
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- One-pot synthesis of five and six membered N, O, S-heterocycles using a ditribromide reagent
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In a one-pot procedure, bromine less brominating reagent 1,1′-(ethane-1,2-diyl)dipyridinium bistribromide (EDPBT) has been utilized as an efficient desulfurizing agent for the construction of a library of heterocycles containing N, O, and S starting from aryl/alkyl isothiocyanates. In this approach, aryl/alkyl isothiocyanate reacts with o-phenylenediamine (o-PD), o-aminophenol, and o-aminothiophenol to form their monothiourea which on desulfurization with EDPBT led to the formation of corresponding 2-aminobenzimidazoles, 2-aminobenzoxazoles, and 2-aminobenzothiazoles, respectively. An interesting regioselectivity was observed for unsymmetrical thiourea having a naphthyl moiety on the one side and an ortho amino or an ortho hydroxy phenyl group on the other side giving a completely different product which is mainly dependent on the nature of the nucleophiles (-OH or -NH 2). Further, the bis-thioureas resulted from the aliphatic 1,2-diamine with 2 equiv of aryl isothiocyanates on treatment with EDPBT gave imidazolidenecarbothioamides, whereas bis-thioureas resulted from aromatic 1,2-diamine yielded benzimidazoles with concurrent expulsion of an isothiocyanate unit. This method is simple and applied to various substrates which are amenable to bromination that reveals the desulfurizing ability of EDPBT predominating over its brominating ability. Finally, the spent reagent EDPDB can be recovered, regenerated, and reused without any loss of activity.
- Yella, Ramesh,Patel, Bhisma K.
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experimental part
p. 754 - 763
(2010/11/03)
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- Simple, novel synthesis for 1-carbamoyl-lH-benzotriazole and some of its analogs
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1-Carbamoyl-1H-benzotriazole (benzotriazole-1-carboxamide, 2a), an effective carbamoyl chloride substitute, and a range of its analogs can be synthesized in good yields in two very simple steps from 1,2-diaminobenzene. The facile preparation of the interm
- Perry, Christopher John,Holding, Keith,Tyrrell, Elizabeth
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p. 3354 - 3365
(2008/12/22)
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- Desulfurization mediated by hypervalent iodine(III): A novel strategy for the construction of heterocycles
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The desulfurization ability of diacetoxyiodobenzene (DIB) has been explored in the preparation of isothiocyanates from the corresponding dithiocarbamate salts. The in situ generated isothiocyanates reacted with o-phenylenediamine and o-aminophenol to form monothioureas, which, on treatment with a further equivalent of DIB in one pot, gave benzimidazoles and aminobenzoxazoles, respectively. Aliphatic 1,2-diamines on reaction with 2 equiv. of isothiocyanate followed by treatment with DIB gave imidazolidenecarbothioamides, whereas the treatment of aromatic 1,2-diaminebis(thioureas) yielded benzimidazoles with the concurrent formation of isothiocyanate. The driving force for the formation of the latter is the aromatization of the product. The use of DIB makes these methods simpler and more efficient, giving high yields of the desired products in one pot. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
- Ghosh, Harisadhan,Yella, Ramesh,Nath, Jayashree,Patel, Bhisma K.
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experimental part
p. 6189 - 6196
(2009/05/27)
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- Synthesis of novel benzo-1,2,5-thiadiazines, their antimicrobial activity and isomerization into benzo-1,2,4-triazines
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Benzo[c]-6-aryl/alkylimino-1,2,5-thiadiazines (4a-g) have been obtained by the basification of benzo[c]-6-aryl/alkylimino-1,2,5-thiadiazine dihydroiodides (3a-g). The latter were synthesized by the oxidative cyclisation of substituted 1-aryl/alkyl-3-(2′-a
- Deohate, Pradip P.,Deohate, Jyoti P.,Berad
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p. 775 - 777
(2007/10/03)
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- Synthesis of 2-(alkylamino)benzimidazoles
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A general and highly convenient procedure for the synthesis of 2- (alkylamino)benzimidazoles has been developed and a variety of analogs have been efficiently prepared. Included is a dipeptide mimetic in which the guanidine group of an arginine residue ha
- Perkins, James J.,Zartman, Amy E.,Meissner, Robert S.
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p. 1103 - 1106
(2007/10/03)
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