21578-46-1

Basic information

• Product Name: 1-(2-aMinophenyl)-1-phenylthiourea
• Synonyms: 1-(2-aMinophenyl)-1-phenylthiourea
• CAS NO: 21578-46-1
• Molecular Formula: C₁₃H₁₃N₃S
• Molecular Weight: 243.32742
• Mol File: 21578-46-1.mol
• Article Data: 12

Chemical Properties

• Melting Point: 147-148 °C(Solv: ethanol (64-17-5))
• Boiling Point: 394.2°Cat760mmHg
• Flash Point: 192.2°C
• Appearance: /
• Density: 1.351g/cm³
• Vapor Pressure: 2.02E-06mmHg at 25°C
• Refractive Index: 1.794
• PKA: 12.21±0.70(Predicted)
• CAS DataBase Reference: 1-(2-aMinophenyl)-1-phenylthiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-aMinophenyl)-1-phenylthiourea(21578-46-1)
• EPA Substance Registry System: 1-(2-aMinophenyl)-1-phenylthiourea(21578-46-1)

Safety Data

• Hazardous Substances Data: 21578-46-1(Hazardous Substances Data)

Usage

General Description

1-(2-aminophenyl)-1-phenylthiourea, also known as APTU, is a chemical compound that belongs to the class of thioureas. It is commonly used in biomedical and pharmaceutical research as a potent inhibitor of endocannabinoid metabolism. APTU has been shown to inhibit the enzyme fatty acid amide hydrolase (FAAH), which is responsible for the degradation of endocannabinoids in the body. This inhibition can lead to an increase in endocannabinoid levels, which have been associated with various physiological and behavioral effects. APTU has also been studied for its potential therapeutic applications in areas such as pain management, anxiety, and neurological disorders. However, it is important to note that APTU should be handled with caution and under controlled conditions due to its potential hazardous effects.

InChI:InChI=1/C13H13N3S/c14-11-8-4-5-9-12(11)16-13(17)15-10-6-2-1-3-7-10/h1-9H,14H2,(H2,15,16,17)

Upstream product

• 64-17-5 ethanol 
• 103-72-0 phenyl isothiocyanate 
• 95-54-5 1,2-diamino-benzene 
• 62-53-3 aniline 
• 6160-65-2 1,1'-Thiocarbonyldiimidazole 

Downstream Products

• 33077-30-4 (1H-benzo[1,2,5]thiadiazin-3-yl)-phenyl-amine 
• 24694-06-2 1-(N-phenylthiocarbamoyl)-1H-benzotriazole 
• 75644-23-4 2-Thioxo-2,3-dihydro-benzoimidazole-1-carbothioic acid phenylamide 
• 90714-96-8 3-Phenyl-1-thia-3,4a,9-triaza-fluorene-2,4-dithione 
• 62-53-3 aniline 
• 1338782-98-1 (E)-1-(2-(3,5-dibromo-2-hydroxybenzylideneamino)phenyl)-3-phenylthiourea 
• 1338783-01-9 (E)-1-(2-(4-chlorobenzylideneamino)phenyl)-3-phenylthiourea 
• 1338783-03-1 (E)-1-(2-(4-methoxybenzylideneamino)phenyl)-3-phenylthiourea 
• 1338783-02-0 (E)-1-(2-(4-bromobenzylideneamino)phenyl)-3-phenylthiourea 
• 1338782-99-2 (E)-1-(2-(5-chloro-2-hydroxybenzylideneamino)phenyl)-3-phenylthiourea 
• 1338783-00-8 (E)-1-(2-(5-bromo-2-hydroxybenzylideneamino)phenyl)-3-phenylthiourea 
• 1401033-00-8 N¹-[N-(4-nitrophenyl)thiocarbamoyl]-N²-[N-phenylthiocarbamoyl]-1,2-diaminobenzene 

Relevant articles and documents

Novel synthesized azo-benzylidene-thiourea as dual naked-eye chemosensor for selective detection of Hg2+ and CNˉ ions

Seven novel chemosensors contain azo chromophore and phenylthiourea, were synthesized and applied as colorimetric probes in aqueous solutions of dimethyl sulfoxide. The anion recognition studies exhibited that the synthesized azo dye derivatives act as a

Potassium Periodate Mediated Oxidative Cyclodesulfurization toward Benzofused Nitrogen Heterocycles

A convenient oxidative cyclodesulfurization method toward the synthesis of benzofused nitrogen heterocycles using inexpensive and readily available potassium periodate as an oxidant was developed. Upon treating isothiocyanates with ortho -substituted anilines bearing N, N -, N, O -, and N, S -bis-nucleophiles, followed by an intramolecular cyclization of the in situ generated monothioureas, substituted 2-aminobenzazole series were rapidly accessible in good to excellent yields. The protocol can accommodate various substituents on both substrates while allowing more efficient, greener, and operational simpler process relative to other oxidative coupling reactions. Tetracyclic quinazolinone derivatives were also afforded in high yields in a single preparative step and chromatography-free.

Click mechanochemistry: Quantitative synthesis of "ready to use" chiral organocatalysts by efficient two-fold thiourea coupling to vicinal diamines

Mechanochemical methods of neat grinding and liquid-assisted grinding have been applied to the synthesis of mono- and bis(thiourea)s by using the click coupling of aromatic and aliphatic diamines with aromatic isothiocyanates. The ability to modify the re