216393-55-4

Basic information

• Product Name: METHYL 3,5-DIFLUOROBENZOATE
• Synonyms: BUTTPARK 89\07-67;METHYL 3,5-DIFLUOROBENZOATE;RARECHEM AL BF 0216;3,5-Difluorobenzoic acid methyl ester;Methyl 3,5-difluorobenzoate 98%;Methyl3,5-difluorobenzoate98%;Methyl 3,5-difluorobenzoate LR Grade
• CAS NO: 216393-55-4
• Molecular Formula: C8H6F2O2
• Molecular Weight: 172.13
• EINECS: -0
• Product Categories: Aromatic Esters;C8 to C9;Carbonyl Compounds;Esters
• Mol File: 216393-55-4.mol

Chemical Properties

• Melting Point: 23-27 °C(lit.)
• Boiling Point: 187-189 °C(lit.)
• Flash Point: 170 °C
• Appearance: /
• Density: 1.265 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.288mmHg at 25°C
• Refractive Index: n20/D 1.4740(lit.)
• Storage Temp.: Room temperature.
• CAS DataBase Reference: METHYL 3,5-DIFLUOROBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3,5-DIFLUOROBENZOATE(216393-55-4)
• EPA Substance Registry System: METHYL 3,5-DIFLUOROBENZOATE(216393-55-4)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22
• Safety Statements: 36
• WGK Germany: 3
• Hazardous Substances Data: 216393-55-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 3,5-DIFLUOROBENZOATE is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows for the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, METHYL 3,5-DIFLUOROBENZOATE is utilized as an intermediate for the production of pesticides and other agrochemicals. Its incorporation aids in enhancing the effectiveness of these products in agricultural applications.
Used in Cosmetic and Personal Care Industry:
METHYL 3,5-DIFLUOROBENZOATE is used as a component in some cosmetic and personal care products. Its presence contributes to the formulation of these products, potentially improving their performance and efficacy.
Used in Organic Synthesis:
As a building block in organic synthesis, METHYL 3,5-DIFLUOROBENZOATE is employed in the creation of a wide range of organic compounds. Its versatility in chemical reactions facilitates the development of new molecules with diverse applications across various industries.

InChI:InChI=1/C8H6F2O2/c1-12-8(11)5-2-6(9)4-7(10)3-5/h2-4H,1H3

Upstream product

• 67-56-1 methanol 
• 455-40-3 3,5-difluorobenzoic acid 

Downstream Products

• 1249074-73-4 C₁₀H₈F₂O 
• 1620567-92-1 4-(4-methylpiperazin-1-yl)-6-(3,5-difluorophenyl)-1,3,5-triazin-2-amine 
• 1620579-73-8 dideutero(3,5-difluorophenyl)methanol 
• 181697-20-1 1-(3,5-difluorophenyl)-2-phenylethanone 
• 1384445-22-0 N-(4-(4-(3,5-difluorobenzyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide-(D₂) 
• 1384448-26-3 C₁₁H₁₂⁽²⁾H₂F₂N₂*ClH 
• 1384448-25-2 C₁₆H₂₀⁽²⁾H₂F₂N₂O₂ 
• 1384448-24-1 C₈H₆⁽²⁾H₂F₂O₃S 

Relevant articles and documents

Method for manufacturing triarylpyrazine derivative

A novel synthesis method of a triarylpyrazine derivative, in particular, a manufacturing method by which a triarylpyrazine derivative, in specific, a 2,3,5-triarylpyrazine derivative in which an aryl group at a 5-position includes a substituent having an electron-withdrawing property can be synthesized with high yield as compared to a conventional method is provided. By using a synthesis method in which a mixture including a 1-aryl-2-(methylsulfinyl)ethanone derivative, meso-1,2-diarylethylenediamine, and a dehydrogenation agent is irradiated with a microwave to be reacted, the above object is achieved.

HETEROCYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS

The present invention provides a heterocyclic compound of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof or a hydrate thereof, wherein A, A′ B, D, R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. Particularly, the present invention provides a compound of formula (I) useful for treating or preventing a disease, condition or disorder associated with protein kinases, preferably Janus Kinase family.

HETEROCYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS

The present invention provides a heterocyclic compound of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof or a hydrate thereof, wherein A, A' B, D, R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. Particularly, the present invention provides a compound of formula (I) useful for treating or preventing a disease, condition or disorder associated with protein kinases, preferably Janus Kinase family.