- Synthesis of esters and amides of 1,4-dihydro-1,2,4,5-tetrazine-3,6- dicarboxylic acid
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Alkyl esters and alkyl amides of 1,4-dihydro-1,2,4,5-tetrazine-3,6- dicarboxylic acid were synthesised and characterised by IR, 1H NMR, EI-MS and elemental analysis. The structure of 1,4-dihydro-1,2,4,5-tetrazine-3, 6-dicarboxylic was confirmed by X-ray diffraction analysis. Some selected compounds were evaluated against P-388 and A-549 cancer cell lines, but showed poor inhibitory activities.
- Zhang, Shi-Jie,Ma, Yi-Chun,Zhou, Wei,Rao, Guo-Wu,Chen, Liang-Liang,Hu, Wei-Xiao
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- Microwave-promoted synthesis of highly luminescent s-tetrazine-1,3,4-oxadiazole and s-tetrazine-1,3,4-thiadiazole hybrids
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Two series of new s-tetrazine derivatives containing 1,3,4-oxadiazole and 1,3,4-thiadiazole rings were synthesized from s-tetrazine-3,6-dicarbohydrazide, triethyl orthoesters and aroyl chlorides. Cyclocondensation reactions for both groups of conjugated arrangements proceeded rapidly and efficiently under microwave irradiation. The obtained compounds exhibited luminescence properties and large quantum yield of emitted photons.
- K?dzia, Anna,Kudelko, Agnieszka,?wi?tkowski, Marcin,Kruszyński, Rafa?
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- Copper-Free Click Reaction Sequence: A Chemoselective Layer-by-Layer Approach
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An additive-free chemoselective ligation of dual clickable building blocks is demonstrated. The challenge of balancing reactivity and stability was achieved by employing a small, electron-deficient tetrazine bearing an azido group and an enol ether functionalized cyclooctyne. The chemoselective sequence of strain-promoted azide-alkyne cycloaddition (SPAAC) and inverse-electron-demand Diels-Alder (IEDDA) reaction is demonstrated with a cholic acid derived triazide as a molecular surface model for layer-by-layer synthesis.
- Meinecke, Jannick,Koert, Ulrich
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supporting information
p. 7609 - 7612
(2019/10/02)
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- Novel scaffolds for beta-helix mimicry
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Functionalized pyridazine derivatives having a low molecular weight and pharmaceutical compositions thereof are useful as alpha-helix mimetics and for treating conditions and/or disorders mediated by alpha-helix-binding receptors and proteins.
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Page/Page column 13
(2008/06/13)
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