216867-32-2

Basic information

• Product Name: 5-PYRID-4-YLTHIOPHENE-2-CARBOXYLIC ACID
• Synonyms: 5-PYRID-4-YLTHIOPHENE-2-CARBOXYLIC ACID;4-(2-Carboxythien-5-yl)pyridine;5-(Pyridin-4-yl)thiophene-2-carboxylic acid 97%;4-(2-Carboxythien-5-yl)pyridine, 2-Carboxy-5-(pyridin-4-yl)thiophene;5-(Pyridin-4-yl)thiophene-2-carboxylicacid97%
• CAS NO: 216867-32-2
• Molecular Formula: C₁₀H₇NO₂S
• Molecular Weight: 205.24
• Mol File: 216867-32-2.mol

Chemical Properties

• Boiling Point: 407.7°Cat760mmHg
• Flash Point: 200.4°C
• Appearance: /
• Density: 1.368g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.643
• CAS DataBase Reference: 5-PYRID-4-YLTHIOPHENE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-PYRID-4-YLTHIOPHENE-2-CARBOXYLIC ACID(216867-32-2)
• EPA Substance Registry System: 5-PYRID-4-YLTHIOPHENE-2-CARBOXYLIC ACID(216867-32-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 216867-32-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Pyrid-4-ylthiophene-2-carboxylic acid is used as a key intermediate in the synthesis of pharmaceutical compounds for drug discovery. Its unique structure allows for the development of new molecules with potential therapeutic applications, including the treatment of various diseases and disorders.
Used in Agrochemical Industry:
In the agrochemical industry, 5-Pyrid-4-ylthiophene-2-carboxylic acid is utilized as a precursor in the synthesis of crop protection agents. Its incorporation into these agents can enhance their effectiveness in controlling pests and diseases, thereby improving crop yield and quality.
Used in Materials Chemistry:
5-Pyrid-4-ylthiophene-2-carboxylic acid is employed as a building block in the development of novel materials with specific properties. Its unique structure can be used to create materials with applications in various fields, such as electronics, optoelectronics, and energy storage.
Overall, 5-Pyrid-4-ylthiophene-2-carboxylic acid is a valuable compound with a wide range of potential applications across different industries, making it an essential component in the development of innovative products and solutions.

InChI:InChI=1/C10H7NO2S/c12-10(13)9-2-1-8(14-9)7-3-5-11-6-4-7/h1-6H,(H,12,13)

Upstream product

• 1120-87-2 4-bromopyridin 
• 19524-06-2 4-bromopyridine hydrochloride 
• 5751-83-7 ethyl 5-bromothiophene-2-carboxylate 
• 1692-15-5 4-pyridylboronic acid 
• 62224-19-5 5-bromo-2-thiophenecarboxylic acid methyl ester 
• 866524-09-6 C₁₂H₁₁NO₂S 

Downstream Products

• 862697-39-0 N-(3-methoxybenzyl)-5-(4-pyridinyl)-2-thiophenecarboxamide 
• 862697-38-9 N-(2-phenylethyl)-5-(4-pyridinyl)-2-thiophenecarboxamide 
• 863409-55-6 C₂₈H₂₄N₆O₃S 

Relevant articles and documents

SPIROCYCLIC CONTAINING COMPOUNDS AND PHARMACEUTICAL USES THEREOF

The present invention relates to a novel family of covalent kinases inhibitors, compounds of this class have been found to have inhibitory activity against members of the TEC kinase family, particularly ITK and/or TXK, BTK, TEC and/or combinations thereof. The present invention is directed to a compound of Formula I or pharmaceutically acceptable salt, solvate, solvates of salt, stereoisomer, tautomer, isotope, prodrug, complex or biologically active metabolite thereof, for use in therapy.

Chemical Compounds

There is provided a compound of Formula (I) or a salt, solvate, or physiologically functional derivative thereof:

Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors

Further investigation of a series of thienyl-based hydroxamic acids that included ADS100380 and ADS102550 led to the identification of the 5-pyridin-2-yl-thiophene-2-hydroxamic acid 3c, which possessed modest HDAC inhibitory activity. Substitution at the

SUBSTITUTED THIOPHENE DERIVATIVES AS ANTI-CANCER AGENTS

The present invention relates to new substituted five-membered compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds

SUBSTITUTED THIENYL-HYDROXAMIC ACIDS AS HISTONE DEACETYLASE INHIBITORS

A compound of formula (I): which can be used in the treatment of diseases associated with histone deacetylase enzymatic activity.