21717-95-3

Basic information

• Product Name: 2-Amino-3-fluoropyridine
• Synonyms: 3-FLUORO-PYRIDIN-2-YLAMINE;2-AMINO-3-FLUOROPYRIDINE;2-Amino-3-fluoropyridine97%;3-FLUOROPYRIDIN-2-AMINE;2-AMINO-3-FLUOROPYRIDINE 98%;BENZYL TERT-BUTANONE;2-AMino-3-fluoropyridine;3-Fluoro-2-aminopyridine
• CAS NO: 21717-95-3
• Molecular Formula: C₅H₅FN₂
• Molecular Weight: 112.11
• Product Categories: Pyridine series;Amines;Pyridines;Pyridine;Fluorine series
• Mol File: 21717-95-3.mol

Chemical Properties

• Melting Point: 39-43℃
• Boiling Point: 110°C/65mmHg(lit.)
• Flash Point: 90℃
• Appearance: light yellow cryst
• Density: 1.257 g/cm³
• Storage Temp.: Refrigerated.
• PKA: 3.95±0.36(Predicted)
• CAS DataBase Reference: 2-Amino-3-fluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3-fluoropyridine(21717-95-3)
• EPA Substance Registry System: 2-Amino-3-fluoropyridine(21717-95-3)

Safety Data

• Hazard Codes: T,Xi,Xn
• Statements: 36/37/38-36-22
• Safety Statements: 26-36/37/39
• RIDADR: UN2811
• WGK Germany: 3
• HazardClass: 6.1
• Hazardous Substances Data: 21717-95-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Amino-3-fluoropyridine is used as a reagent for the synthesis of potent sigma-1 receptor antagonists and mu opioid receptor agonists. These compounds are crucial in the treatment of neuropathic pain, a chronic pain condition that affects many individuals worldwide. The development of effective treatments for neuropathic pain is of significant importance, and 2-Amino-3-fluoropyridine plays a vital role in this process.
Additionally, due to its unique chemical structure, 2-Amino-3-fluoropyridine may have potential applications in other areas of the pharmaceutical industry, such as the development of new drugs targeting different receptors or enzymes. Further research and development are necessary to fully explore and understand the compound's capabilities and potential applications in various therapeutic areas.

Upstream product

• 67-63-0 isopropyl alcohol 

Downstream Products

• 139022-26-7 8-fluoroimidazo[1,2-a]pyridine 
• 1245815-62-6 3-benzyl-8-fluoro-2-phenyl-1H-imidazo[1,2-a]pyridine 
• 1267851-05-7 2-(4-(6-amino-5-fluoropyridin-3-yl)phenyl)-N-(5-tert-butylisoxazol-3-yl)acetamide 
• 1267851-06-8 5-(4-(2-(5-tert-butylisoxazol-3-ylamino)-2-oxoethyl)phenyl)-3-fluoropyridin-2-aminium methanesulfonate 
• 1269440-67-6 3-fluoro-4-iodopyridin-2-amine 
• 1196091-77-6 (R)-1-[(3-Fluoro-pyridin-2-ylcarbamoyl)-methyl]-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane chloride 
• 1447463-72-0 N-(3-fluoropyridin-2-yl)-2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)acetamide 
• 1211590-31-6 3-fluoro-5-methylpyridin-2-amine 
• 1276618-69-9 C₁₆H₁₀F₂N₄O₂ 
• 1276618-19-9 C₁₆H₁₀ClFN₄O₂ 

Relevant articles and documents

PROCESS FOR THE CATALYTIC DIRECTED CLEAVAGE OF AMIDE-CONTAINING COMPOUNDS

The present invention relates to a catalytic method for the conversion of amide-containing compouds by means of a build-in directing group and upon the action of a heteronucleophilic compound (in se an amine (RNH2 or RNHR') or an alcohol (ROH) or a thiol (RSH)) in the presence of a metal catalyst to respectively esters, thioesters, carbonates, thiocarbonates and to what is defined as amide-containing compounds (such as carboxamides, urea, carbamates, thiocarbamates). The present invention also relates to these amide-containing compounds having a build-in directing group (DG), as well as the use of such directing groups in the catalytic directed cleavage of N-DG amides with the use of heteronucleophiles (in se an amine (RNH2 or RNHR') or an alcohol (ROH) or thiol (RSH)).